TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

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2001 • 4,673 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

2001 • 1,231 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

2001 • 1,078 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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TIRAP: an adapter molecule in the Toll signaling pathway

2001 • 962 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

2001 • 693 citations

Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages

2001 • 669 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

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Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

ENDOTOXIN IN HEALTH AND DISEASE

2000 • 484 citations

The growing family of interferon regulatory factors

1997 • 480 citations

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

1999 • 445 citations

Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways

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CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression

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Different Toll-like receptor agonists induce distinct macrophage responses

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Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo

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Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

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Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses

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Requirement for STAT1 in LPS-induced gene expression in macrophages

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Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene.

1998 • 227 citations

Mosaic Genes and Mosaic Chromosomes: Intra- and Interspecies Genomic Variation of Streptococcus pneumoniae

2001 • 218 citations

Autocrine/Paracrine IFN-αβ Mediates the Lipopolysaccharide-Induced Activation of Transcription Factor Stat1α in Mouse Macrophages: Pivotal Role of Stat1α in Induction of the Inducible Nitric Oxide Synthase Gene

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Identification of Distinct Signaling Pathways Leading to the Phosphorylation of Interferon Regulatory Factor 3

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Induction of IFN-γ in macrophages by lipopolysaccharide

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Induction of Tolerance to Lipopolysaccharide and Mycobacterial Components in Chinese Hamster Ovary/CD14 Cells Is Not Affected by Overexpression of Toll-Like Receptors 2 or 4

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The interferon system and interferon regulatory factor transcription factors – studies from gene knockout mice

2001 • 162 citations

Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages

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Pulmonary and Hepatic Gene Expression following Cecal Ligation and Puncture: Monophosphoryl Lipid A Prophylaxis Attenuates Sepsis-Induced Cytokine and Chemokine Expression and Neutrophil Infiltration

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Taxol provides a second signal for murine macrophage tumoricidal activity.

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Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer Orientation

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Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-β

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Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages

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Bacterial Induction of Beta Interferon in Mice Is a Function of the Lipopolysaccharide Component

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APC Stimulated by CpG Oligodeoxynucleotide Enhance Activation of MHC Class I-Restricted T Cells

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Gene Repression by Coactivator Repulsion

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Regulation of Interferon-β Gene: Structure and Function ofcis-Elements andtrans-Acting Factors

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Effect of cycloheximide on the expression of LPS‐inducible iNOS, IFN‐β, and IRF‐1 genes in J774 macrophages

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