Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

APP Processing and Synaptic Function

2003 • 1,575 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses

1996 • 1,088 citations

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

2005 • 993 citations

Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases

2004 • 883 citations

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

2000 • 781 citations

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

1999 • 759 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Nonuniform Probability of Glutamate Release at a Hippocampal Synapse

1993 • 641 citations

Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β‐Protein

2000 • 613 citations

Released Fraction and Total Size of a Pool of Immediately Available Transmitter Quanta at a Calyx Synapse

1999 • 607 citations

Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture.

1991 • 589 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.

2001 • 516 citations

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

2001 • 501 citations

Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

2000 • 485 citations

The Developing Synapse: Construction and Modulation of Synaptic Structures and Circuits

2002 • 453 citations

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In VitroandIn VivoMechanisms Related to Alzheimer's Disease

2001 • 446 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

1993 • 388 citations

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

2005 • 374 citations

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

1999 • 362 citations

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

1994 • 349 citations

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

1999 • 346 citations

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

2004 • 330 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

Alzheimer's β-Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line

2000 • 291 citations

Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections.

1990 • 263 citations

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

2003 • 263 citations

Stages of Synapse Development Defined by Dependence on F-Actin

2001 • 253 citations

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1999 • 247 citations

The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

2003 • 221 citations

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

1993 • 215 citations

AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice

2006 • 214 citations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

1989 • 212 citations

Growth cone and dendrite dynamics in zebrafish embryos: early events in synaptogenesis imaged in vivo

2000 • 210 citations

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

1990 • 209 citations

Enhancement of Outward Potassium Current May Participate in β-Amyloid Peptide-Induced Cortical Neuronal Death

1998 • 188 citations

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

1995 • 179 citations

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

1995 • 162 citations

Role of Potassium Channels in Amyloid‐Induced Cell Death

1998 • 154 citations

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.

1996 • 145 citations

No hippocampal neuron or synaptic bouton loss in learning-impaired aged β-Amyloid precursor protein-null mice

1999 • 115 citations

Hypersensitivity to seizures in β-amyloid precursor protein deficient mice

1998 • 112 citations

Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid β protein (1–40) is dependent on solubility status

2002 • 84 citations

Differential effects of unaggregated and aggregated amyloid β protein (1–40) on K⁺ channel currents in primary cultures of rat cerebellar granule and cortical neurones

2001 • 79 citations

Diversity of amyloid beta protein fragment [1-40]-formed channels.

2001 • 74 citations

Amyloid peptide channels: Blockade by zinc and inhibition by Congo red (amyloid channel block)

2000 • 72 citations

Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function

2005 • 66 citations

Amyloid beta protein increases Ca2+ currents in rat cerebellar granule neurones.

1998 • 39 citations

A Method to Perform Western Blots of Microscopic Areas of Histological Sections

2006 • 21 citations