Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Bacteriophage P1 site-specific recombination

1981 • 762 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Chromosome engineering in mice

1995 • 479 citations

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene

1987 • 479 citations

Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae.

1987 • 476 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

1993 • 309 citations

Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene

1994 • 307 citations

Cre-stimulated recombination atloxP-containing DNA sequences placed into the mammalian genome

1989 • 262 citations

Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.

1990 • 253 citations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

1994 • 186 citations

A transcribed gene in an intron of the human factor VIII gene

1990 • 182 citations

Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP.

1984 • 178 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

Expression of retroviral vectors in transgenic mice obtained by embryo infection.

1987 • 128 citations

Cre recombinase-mediated site-specific recombinationbetween plant chromosomes.

1994 • 114 citations

Infertility in Male Transgenic Mice: Disruption of Sperm Development by HSV-tk Expression in Postmeiotic Germ Cells1

1990 • 101 citations

Targeting the mouse genome: a compendium of knockouts (part II)

1995 • 99 citations

Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.

1993 • 82 citations

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.

1994 • 37 citations

Flagellar and Acrosomal Abnormalities Associated with Testicular HSV-tk Expression in the Mouse1

1993 • 30 citations