Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

Structural basis of long-term potentiation in single dendritic spines

2004 • 2,331 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

PSD-95 Involvement in Maturation of Excitatory Synapses

2000 • 1,238 citations

AMPA Receptor Trafficking at Excitatory Synapses

2003 • 1,121 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 • 861 citations

Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation

1996 • 844 citations

Structure–stability–function relationships of dendritic spines

2003 • 824 citations

γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

2002 • 820 citations

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

2003 • 722 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons

2000 • 710 citations

γ-Secretase: proteasome of the membrane?

2004 • 543 citations

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

2002 • 505 citations

Assembly of New Individual Excitatory Synapses

2000 • 490 citations

New Frontiers in Alzheimer's Disease Genetics

2001 • 470 citations

Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin

2003 • 466 citations

Signal transduction underlying growth cone guidance by diffusible factors

1999 • 457 citations

A Mass Spectrometry-based Proteomic Approach for Identification of Serine/Threonine-phosphorylated Proteins by Enrichment with Phospho-specific Antibodies

2002 • 387 citations

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

2003 • 384 citations

Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning

2003 • 374 citations

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

2000 • 366 citations

Depolarization Drives β-Catenin into Neuronal Spines Promoting Changes in Synaptic Structure and Function

2002 • 335 citations

Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

1996 • 327 citations

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

2000 • 300 citations

Mechanisms of Synapse Assembly and Disassembly

2003 • 297 citations

Spine Formation and Correlated Assembly of Presynaptic and Postsynaptic Molecules

2001 • 288 citations

Rapid recruitment of NMDA receptor transport packets to nascent synapses

2002 • 283 citations

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system

1993 • 280 citations

Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

2002 • 263 citations

Electrical Activity Modulates Growth Cone Guidance by Diffusible Factors

2001 • 262 citations

Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon

2003 • 258 citations

The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM

2003 • 249 citations

AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks

2003 • 239 citations

Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor

2000 • 216 citations

The Netrin-1 Receptor DCC Promotes Filopodia Formation and Cell Spreading by Activating Cdc42 and Rac1

2002 • 203 citations

Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway

2002 • 193 citations

Signaling mechanisms that regulate actin‐based motility processes in the nervous system

2002 • 184 citations

Function of an Axonal Chemoattractant Modulated by Metalloprotease Activity

2000 • 165 citations

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration

2004 • 161 citations

Modular Transport of Postsynaptic Density-95 Clusters and Association with Stable Spine Precursors during Early Development of Cortical Neurons

2001 • 125 citations

Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline

2003 • 113 citations

Presenilin-dependent “γ-Secretase” Processing of Deleted in Colorectal Cancer (DCC)

2003 • 97 citations

Chapter 32 Where the rubber meets the road: netrin expression and function in developing and adult nervous systems

2002 • 81 citations

In the eye of the beholder

2003 • 68 citations

Identification of the role of presenilins beyond Alzheimer?s disease

2004 • 66 citations