Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Recent developments in Parkinson's disease

1986 • 2,266 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

Progress in Psychobiology and Physiological Psychology

2003 • 1,683 citations

Treatment-Induced Cortical Reorganization After Stroke in Humans

2000 • 1,408 citations

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

1999 • 1,387 citations

CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

2000 • 1,288 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Handbook of Psychopharmacology

1978 • 1,034 citations

Constraint-Induced Movement Therapy: a new family of techniques with broad application to physical rehabilitation--a clinical review.

1999 • 985 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

1999 • 687 citations

Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

1997 • 637 citations

Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase

1999 • 561 citations

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.

1996 • 544 citations

Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

1996 • 541 citations

Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy

1995 • 540 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway.

2000 • 517 citations

Use-dependent growth of pyramidal neurons after neocortical damage

1994 • 513 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

1994 • 453 citations

BDNF Protects the Neonatal Brain from Hypoxic-Ischemic InjuryIn Vivovia the ERK Pathway

2000 • 432 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Use-Dependent Exaggeration of Neuronal Injury after Unilateral Sensorimotor Cortex Lesions

1996 • 386 citations

Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus

1998 • 385 citations

Glial Cell Line-Derived Neurotrophic Factor Is Expressed in the Developing but Not Adult Striatum and Stimulates Developing Dopamine Neurons in Vivo

1993 • 384 citations

GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo

1995 • 374 citations

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

1998 • 360 citations

RECOVERY OF FUNCTION AFTER DAMAGE TO CENTRAL CATECHOLAMINE-CONTAINING NEURONS: A NEUROCHEMICAL MODEL FOR THE LATERAL HYPOTHALAMIC SYNDROME

1976 • 357 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Neurochemical Compensation After Nigrostriatal Bundle Injury in an Animal Model of Preclinical Parkinsonism

1984 • 340 citations

Effects ofl-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats

1990 • 334 citations

Recovery recapitulates ontogeny

2000 • 318 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

1991 • 310 citations

Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

1972 • 296 citations

Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat

2000 • 293 citations

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra

1997 • 290 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise

1998 • 267 citations

Dyskinesia after fetal cell transplantation for parkinsonism: A PET study

2002 • 259 citations

Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period

1998 • 254 citations

Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1973 • 251 citations

Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF

2003 • 246 citations

Differential Regulation of mRNAs for GDNF and its Receptors Ret and GDNFRα After Sciatic Nerve Lesion in the Mouse

1997 • 242 citations

Use-dependent structural events in recovery of function.

1997 • 223 citations

Catecholamine toxicity in cerebral cortex in dissociated cell culture

1988 • 207 citations

Pre- and Postsynaptic Neurotoxic Effects of Dopamine Demonstrated by Intrastriatal Injection

1993 • 204 citations

Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain

2001 • 201 citations

Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications

1989 • 194 citations

Ultrastructural localization of D1 dopamine receptor immunoreactivity in rat striatonigral neurons and its relation with dopaminergic innervation

1996 • 191 citations

Early Exclusive Use of the Affected Forelimb After Moderate Transient Focal Ischemia in Rats

2000 • 184 citations

Glial hypertrophy is associated with synaptogenesis following motor‐skill learning, but not with angiogenesis following exercise

1994 • 183 citations

Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions.

1976 • 180 citations

Differential Effects of Glial Cell Line‐Derived Neurotrophic Factor and Neurturin on Developing and Adult Substantia Nigra Dopaminergic Neurons

1999 • 177 citations

Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury

2002 • 163 citations

Exercise therapy for Parkinson's disease

1986 • 161 citations

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

1990 • 159 citations

Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain

1999 • 152 citations

The effects of a balance and strength training program on equilibrium in Parkinsonism: A preliminary study

2000 • 150 citations

Experience-Associated Structural Events, Subependymal Cellular Proliferative Activity, and Functional Recovery After Injury to the Central Nervous System

2000 • 143 citations

The Role of Physical Exercise in the Occurrence of Parkinson's Disease

1992 • 142 citations

Non-synaptic Interactions Between Neurons: Modulation of Neurochemical Transmission

1985 • 136 citations

Do Compensatory Processes Underlie the Preclinical Phase of Neurodegenerative Disease? Insights from an Animal Model of Parkinsonism

1997 • 134 citations

Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?

1999 • 124 citations

Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease.

1995 • 121 citations

ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2

1999 • 119 citations

Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation

2000 • 108 citations

Stress-induced Parkinson's disease: a working hypothesis

2002 • 108 citations

The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens

1991 • 102 citations

The influence of environment and experience on neural grafts

2001 • 102 citations

When did Ray Kennedy's Parkinson's disease begin?

1992 • 102 citations

Pathophysiology of Parkinson's disease

1999 • 101 citations

Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

1992 • 99 citations

‘Disengage’ sensorimotor deficit following apparent recovery from unilateral dopamine depletion

1988 • 96 citations

A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats

1973 • 92 citations

Effects of GDNF on 6‐OHDA‐induced death in a dopaminergic cell line: Modulation by inhibitors of PI3 kinase and MEK

2003 • 88 citations

Spiny neurons lacking choline acetyltransferase immunoreactivity are major targets of cholinergic and catecholaminergic terminals in rat striatum

1990 • 84 citations

Motor training effects on recovery of function after striatal lesions and striatal grafts

2003 • 81 citations

Activation of the Mitogen-Activated Protein Kinase (ERK_1/2) Signaling Pathway by Cyclic AMP Potentiates the Neuroprotective Effect of the Neurotransmitter Noradrenaline on Dopaminergic Neurons

2002 • 78 citations

Chemical and Immunochemical Lesions by Specific Neurotoxic Substances and Antisera

1975 • 66 citations

The Benefit of a Home Exercise Regimen for Ambulatory Parkinsonʼs Disease Patients

1989 • 61 citations

Relationship between dendritic pruning and behavioral recovery following sensorimotor cortex lesions

1998 • 58 citations

Dynamic expression of glial cell line-derived neurotrophic factor after cerebral ischemia

2000 • 53 citations

Dopamine Terminal Loss and Onset of Motor Symptoms in MPTP-Treated Monkeys: A Positron Emission Tomography Study with 11C-CFT

1994 • 49 citations

Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model

1999 • 48 citations

GDNF mRNA expression in normal postnatal development, aging, and in weaver mutant mice

1995 • 47 citations

Movement-related glutamate levels in rat hippocampus, striatum, and sensorimotor cortex

1999 • 46 citations

Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum

1997 • 46 citations

Combined Action of ERK and NFκB Mediates the Protective Effect of Phorbol Ester on Fas-induced Apoptosis in Jurkat Cells

2003 • 45 citations

Adjunctive treatment in Parkinson's disease: physical therapy and comprehensive group therapy.

1982 • 45 citations

Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts

1999 • 42 citations

Nigrostriatal system plasticity in Parkinson's disease: effect of dopaminergic denervation and treatment.

2000 • 42 citations

Brain-derived and glial cell line-derived neurotrophic factors protect a catecholaminergic cell line from dopamine-induced cell death

1999 • 42 citations

Glial cell line derived neurotrophic factor promotes the recovery of dopamine neurons damaged by 6-hydroxydopamine in vitro

1999 • 38 citations

Aging‐dependent Emergence of Sensorimotor Dysfunction in Rats Recovered from Dopamine Depletion Sustained Early in Lifea

1988 • 38 citations

Induction of glial cell line-derived neurotrophic factor and c-ret porto-oncogene-like immunoreactivity in rabbit spinal cord after transient ischemia

1999 • 38 citations

Establishing Physical Objectives in the Rehabilitation of Patients with Parkinson’s Disease (Gymnasium Activities)

1956 • 38 citations

Constraint-Induced Movement Therapy

2017 • 30 citations

Localization of dopamine carriers by BTCP, a dopamine uptake inhibitor, on nigral cells cultured in vitro

1991 • 29 citations

6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals

1998 • 26 citations

Long distance signalling in volume transmission. Focus on clearance mechanisms

2000 • 26 citations

Report of a Case of Parkinsonism Treated with Proprioceptive Facilitation Technics

1957 • 19 citations

Highly Selective Neurotoxins

1998 • 17 citations

Chapter 15 Chemical transmission in the brain: homeostatic regulation and its functional implications

1994 • 17 citations

When it comes to communications between neurons, synapses are over-rated: Insights from an animal model of Parkinsonism

2000 • 9 citations