Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY

1973 • 2,780 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

PATTERN OF MALFORMATION IN OFFSPRING OF CHRONIC ALCOHOLIC MOTHERS

1973 • 2,156 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

SALMONELLAS IN MEAT.

1964 • 1,158 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Alcohol‐Induced Neuronal Loss in Developing Rats: Increased Brain Damage with Binge Exposure

1990 • 558 citations

The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration

1997 • 520 citations

FETAL ALCOHOL SYNDROME

1998 • 496 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro

1995 • 435 citations

Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus

1981 • 384 citations

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

1998 • 365 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

1999 • 288 citations

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

1998 • 284 citations

Numbers of neurons and glia in mature rat somatosensory cortex: Effects of prenatal exposure to ethanol

1990 • 277 citations

Role of MAP kinase in neurons

1998 • 250 citations

The Effects of the Timing of Ethanol Exposure during the Brain Growth Spurt on the Number of Cerebellar Purkinje and Granule Cell Nuclear Profiles

1993 • 249 citations

Abnormal Development of the Cerebellar Vermis in Children Prenatally Exposed to Alcohol: Size Reduction in Lobules I–V

1996 • 243 citations

Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt

1991 • 239 citations

Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

1997 • 213 citations

Effects of Ethanol Exposure during the Third Trimester Equivalent on Neuron Number in Rat Hippocampus and Dentate Gyrus

1986 • 173 citations

Aminophospholipid translocase of human erythrocytes: phospholipid substrate specificity and effect of cholesterol

1989 • 172 citations

Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase

1996 • 168 citations

Differential neuronal loss following early postnatal alcohol exposure

1989 • 157 citations

Ethanol Promotes Apoptosis in Cerebellar Granule Cells by Inhibiting the Trophic Effect of NMDA

1997 • 147 citations

Developing rat Purkinje cells are more vulnerable to alcohol-induced depletion during differentiation than during neurogenesis

1994 • 142 citations

Ethanol‐Induced Neural Crest Apoptosis Is Coincident with Their Endogenous Death, But Is Mechanistically Distinct

1998 • 140 citations

Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver

1998 • 134 citations

Ethanol Induces Apoptosis in Cerebellar Granule Neurons by Inhibiting Insulin‐Like Growth Factor 1 Signaling

1998 • 125 citations

Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells

1998 • 123 citations

Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: A stereological investigation

1995 • 122 citations

Nerve Growth Factor and Basic Fibroblast Growth Factor Protect Rat Cerebellar Granule Cells in Culture against Ethanol‐Induced Cell Death

1997 • 116 citations

Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

1997 • 111 citations

An Inhibitor of p38 and JNK MAP Kinases Prevents Activation of Caspase and Apoptosis of Cultured Cerebellar Granule Neurons

1999 • 110 citations

Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: A stereological study

1992 • 106 citations

Responsiveness of cultured septal and hippocampal neurons to ethanol and neurotrophic substances

1994 • 85 citations

Alcohol reduces the number of pheochromocytoma (PC12) cells in culture

1992 • 77 citations

Neuroanatomic and Neurochemical Abnormalities in Non‐human Primate Infants Exposed to Weekly Doses of Ethanol during Gestation

1990 • 76 citations

Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages.

1997 • 75 citations

Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic

1997 • 75 citations

Modulation of ethanol neurotoxicity by nerve growth factor

1993 • 75 citations

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

1997 • 73 citations

Ethanol-induced cell death in cultured rat astroglia

1997 • 66 citations

Cell Cycle Kinetics in Fetal Rat Cerebral Cortex: Effects of Prenatal Treatment with Ethanol Assessed by a Cumulative Labeling Technique with Flow Cytometry

1995 • 65 citations

Nerve growth factor (NGF) regulation of estrogen receptors in explant cultures of the developing forebrain

1996 • 64 citations

ACETALDEHYDE INDUCES C-FOS AND C-JUN PROTO-ONCOGENES IN FAT-STORING CELL CULTURES THROUGH PROTEIN KINASE C ACTIVATION

1994 • 62 citations

NMDA Prevents Alcohol‐Induced Neuronal Cell Death of Cerebellar Granule Cells in Culture

1995 • 58 citations

Glial-derived neurotrophic factor rescues calbindin-D28k-immunoreactive neurons in alcohol-treated cerebellar explant cultures

1997 • 57 citations

Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages

1996 • 40 citations

Alterations in responsiveness to ethanol and neurotrophic substances in fetal septohippocampal neurons following chronic prenatal ethanol exposure

1995 • 39 citations

Chronic Alcohol Ingestion Enhances Tumor Necrosis Factor‐α Expression and Salivary Gland Apoptosis

1997 • 39 citations

Ethanol Decreases Glial Derived Neurotrophic Factor (GDNF) Protein Release but Not mRNA Expression and Increases GDNF‐Stimulated Shc Phosphorylation in the Developing Cerebellum

1999 • 38 citations

Chronic Alcohol Ingestion: Nerve Growth Factor Gene Expression and Neurotrophic Activity in Rat Hippocampus

1994 • 38 citations

Induction of the c-jun proto-oncogene by a protein kinase c-dependent mechanism during exposure of human epidermal keratinocytes to ethanol

1993 • 37 citations

Structure and Expression of Carp Mitogen--Activated Protein Kinases Homologous to Mammalian JNK/SAPK

1997 • 28 citations

Tyrosine Phosphorylation of p38 but Not Extracellular Signal-Regulated Kinase in Normal Human Neutrophils Stimulated by Tumor Necrosis Factor: Comparative Study with Granulocyte-Macrophage Colony-Stimulating Factor

1997 • 23 citations

Alcohol effects on the fetus.

1980 • 17 citations

Ethanol-induced apoptosis in human HL-60 cells

1997 • 17 citations

Chronic ethanol enhances NMDA-induced AP-1 activity in cultured rat cerebellar granule cells

1996 • 16 citations

Ethanol neuronotoxicity in the embryonic chick brain in ovo and in culture: Interaction of the neural cell adhesion molecule (NCAM)

1995 • 15 citations

Ethanol Exposure Potentiates fosB and junB Expression Induced by Muscarinic Receptor Stimulation in Neuroblastoma SH‐SY5Y Cells

1998 • 13 citations

Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells

1996 • 9 citations

Expression of the JNK2-α1 Gene in the Developing Chick Brain

1997 • 8 citations

Ethanol neurotoxicity on neuroblast‐enriched cultures from three‐day‐old chick embryo is attenuated by the neuronotrophic action of GABA

1995 • 7 citations