Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Role of Free Radicals in the Neurodegenerative Diseases

2001 • 1,490 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Constraint-Induced Movement Therapy: a new family of techniques with broad application to physical rehabilitation--a clinical review.

1999 • 985 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Nigrostriatal bundle damage and the lateral hypothalamic syndrome.

1974 • 632 citations

Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy

2001 • 593 citations

Use-dependent growth of pyramidal neurons after neocortical damage

1994 • 513 citations

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

1994 • 453 citations

Animal models of neurological deficits: how relevant is the rat?

2002 • 447 citations

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

2003 • 401 citations

GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo

1995 • 374 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Longer versus shorter daily constraint-induced movement therapy of chronic hemiparesis: An exploratory study

2002 • 289 citations

Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo.

1992 • 280 citations

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease

1995 • 269 citations

Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise

1998 • 267 citations

Short-Term GDNF Treatment Provides Long-Term Rescue of Lesioned Nigral Dopaminergic Neurons in a Rat Model of Parkinson’s Disease

1996 • 258 citations

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

1999 • 257 citations

Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model

1977 • 201 citations

Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor

1998 • 195 citations

Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus

1998 • 184 citations

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

2001 • 183 citations

Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions.

1976 • 180 citations

Differential Effects of Glial Cell Line‐Derived Neurotrophic Factor and Neurturin on Developing and Adult Substantia Nigra Dopaminergic Neurons

1999 • 177 citations

Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury

2002 • 163 citations

Constraint-induced movement therapy to enhance recovery after stroke

2001 • 158 citations

Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism

2000 • 152 citations

The effects of a balance and strength training program on equilibrium in Parkinsonism: A preliminary study

2000 • 150 citations

751. Delayed Delivery of AAV-GDNF Prevents Nigral Neurodegeneration and Promotes Functional Recovery in a Rat Model of Parkinson's Disease

2002 • 148 citations

The Role of Physical Exercise in the Occurrence of Parkinson's Disease

1992 • 142 citations

Reactive capacity: A sensitive behavioral marker of movement initiation and nigrostriatal dopamine function

1985 • 125 citations

A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia

1992 • 124 citations

Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus

2001 • 121 citations

An Acid-Treatment Method for the Enhanced Detection of GDNF in Biological Samples

1997 • 119 citations

Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo

1995 • 119 citations

Environmental risk factors of young onset Parkinson's disease: a case-control study

2002 • 85 citations

GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells

1996 • 83 citations

Paradoxical Kinesia in Parkinsonism Is Not Caused by Dopamine Release

1989 • 62 citations

Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

1990 • 60 citations

HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height.

1996 • 49 citations

Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model

1999 • 48 citations

Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine

2000 • 44 citations

Brain-derived and glial cell line-derived neurotrophic factors protect a catecholaminergic cell line from dopamine-induced cell death

1999 • 42 citations

Glial cell line derived neurotrophic factor promotes the recovery of dopamine neurons damaged by 6-hydroxydopamine in vitro

1999 • 38 citations

Effect of Bilateral 6-Hydroxydopamine Lesions of the Medial Forebrain Bundle on Reaction Time

2002 • 38 citations

HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height.

1996 • 38 citations

Expression of Brain-derived Neurotrophic Factor mRNA Stimulated by Basic Fibroblast Growth Factor and Platelet-derived Growth Factor in Rat Hippocampal Cell Line

1997 • 33 citations

6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals

1998 • 26 citations

6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals: Lessons from the Neostriatum

2003 • 10 citations