When it comes to communications between neurons, synapses are over-rated: Insights from an animal model of Parkinsonism

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN

1970 • 653 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1990 • 597 citations

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis

1984 • 576 citations

Recent Developments in Parkinson's Disease

1987 • 552 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

1980 • 498 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Frontiers in Catecholamine Research

1976 • 451 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

1969 • 421 citations

Volume transmission in the brain. Novel mechanisms for neural transmission

1992 • 388 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: Pharmacological and behavioral studies

1988 • 345 citations

Neurochemical Compensation After Nigrostriatal Bundle Injury in an Animal Model of Preclinical Parkinsonism

1984 • 340 citations

Effects ofl-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats

1990 • 334 citations

Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

1972 • 296 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1973 • 251 citations

Effect of dopamine receptor agonists and antagonists on release of dopamine in the rabbit caudate nucleus in vitro

1978 • 242 citations

Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

1979 • 237 citations

Effects of dopaminergic receptor agonists and antagonists on the activity of the neo-striatal cholinergic system

1975 • 236 citations

Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.

1977 • 222 citations

Animal models in psychiatry and neurology

1977 • 213 citations

Foundations of the Neuron Doctrine

1994 • 206 citations

Molecular regulators of brain function: A new view

1984 • 182 citations

Dopamine receptor changes following destruction of the nigrostriatal pathway: Lack of a relationship to rotational behavior

1981 • 164 citations

Time Course of Adaptations in Dopamine Biosynthesis, Metabolism, and Release Following Nigrostriatal Lesions: Implications for Behavioral Recovery from Brain Injury

1987 • 160 citations

Modulation by endogenous dopamine of the release of acetylcholine in the caudate nucleus of the rabbit

1980 • 159 citations

THE RELEASE OF LABELLED ACETYLCHOLINE AND CHOLINE FROM CEREBRAL CORTICAL SLICES STIMULATED ELECTRICALLY

1974 • 152 citations

Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage

1988 • 149 citations

Increased dopamine efflux from striatal slices during development and after nigrostriatal bundle damage

1987 • 143 citations

Dopamine efflux from striatal slices after intracerebral 6-hydroxydopamine: evidence for compensatory hyperactivity of residual terminals.

1990 • 136 citations

Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms.

1993 • 135 citations

Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: Histochemical and neurochemical analysis

1986 • 131 citations

Herabgesetzte Konzentration der Homovanillinsäure im Gehirn von parkinsonkranken Menschen als Ausdruck der Störung des zentralen Dopaminstoffwechsels

1965 • 126 citations

Influence of dopamine on GABA release in striatum: evidence for D1–D2 interactions and non-synaptic influences

1997 • 113 citations

Short-Term increase and long-term reversion of striatal cell activity after degeneration of the nigrostriatal dopamine system

1978 • 110 citations

The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons

1990 • 109 citations

The relationship between loss of dopamine nerve terminals, striatal [3H]spiroperidol binding and rotational behavior in unilaterally 6-hydroxydopamine-lesioned rats

1981 • 106 citations

Foundations of the neuron doctrine

1992 • 103 citations

A LHRH-like peptidergic neurotransmitter capable of ‘action at a distance’ in autonomic ganglia

1983 • 101 citations

Short and long term changes in tyrosine hydroxylase activity in rat brain after subtotal destruction of central noradrenergic neurons

1981 • 101 citations

Ultrastructural demonstration of nonsynaptic release sites in the central nervous system of the snail lymnaea stagnalis, the insect periplaneta americana, and the rat

1986 • 99 citations

High glutamate concentrations evoke Ca(++)-independent dopamine release from striatal slices: a possible role of reverse dopamine transport.

1991 • 97 citations

A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats

1973 • 92 citations

Nonsynaptic characteristics of neurotransmission mediated by egg-laying hormone in the abdominal ganglion of Aplysia

1985 • 90 citations

DEMONSTRATION OF ACETYLCHOLINE RELEASE BY MEASURING EFFLUX OF LABELLED CHOLINE FROM CEREBRAL CORTICAL SLICES

1972 • 89 citations

Long-term effects of dopamine-depleting brain lesions on spontaneous activity of type II striatal neurons: Relation to behavioral recovery

1986 • 85 citations

Alterations in consummatory behavior following intracisternal injection of 6-hydroxydopamine

1973 • 84 citations

Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion

1980 • 78 citations

Extracellular levels of amino acids in striatum and globus pallidus of 6-hydroxydopamine-lesioned rats measured with microdialysis

1986 • 75 citations

Subtotal destruction of central noradrenergic projections increases the firing rate of locus coeruleus cells

1983 • 72 citations

Short-term effects of dopamine-depleting brain lesions on spontaneous activity of striatal neurons: Relation to local dopamine concentration and behavior

1986 • 70 citations

Nonsynaptic diffusion neurotransmission (NDN) in the brain

1993 • 69 citations

Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.

1985 • 68 citations

HOMOVANILLIC ACID AND DIHYDROXYPHENYLACETIC ACID IN THE STRIATUM OF MONKEYS WITH BRAIN LESIONS

1967 • 61 citations

Frequency-Dependent Release of Acetylcholine and Dopamine From Rabbit Striatum: Its Modulation by Dopaminergic Receptors

1983 • 60 citations

Dopaminergic inhibition of striatal acetylcholine release after 6-hydroxydopamine

1989 • 58 citations

A topographic measurement of brain pH

1980 • 55 citations

Non-Synaptic Interactions Between Neurons: Modulation of Neurochemical Transmission : Pharmacological and Clinical Aspects

1984 • 53 citations

Tyrosine Hydroxylase Content of Residual Striatal Dopamine Nerve Terminals Following 6-Hydroxydopamine Administration: A Flow Cytometric Study

1989 • 50 citations

Nonclassical neuronal communications.

1983 • 46 citations

Chemical Transmission of Nerve Impulses: A Historical Sketch

1974 • 36 citations

Changes in the retention and metabolism of 3 H-l-norepinephrine in rat brain in vivo after 6-hydroxydopamine pretreatment.

1971 • 35 citations

Adaptive Properties of Monoaminergic Neurons

1985 • 34 citations

6-Hydroxydopamine and striatal acetylcholine levels

1974 • 33 citations

Current concepts in Parkinson's disease research

1995 • 31 citations

Partial dopamine depletions result in an enhanced sensitivity of residual dopamine neurons to apomorphine

1991 • 25 citations

Dopamine released from mesencephalic transplants restores modulation of striatal acetylcholine release after neonatal 6-hydroxydopamine: An in vitro analysis

1989 • 25 citations

Spontaneous activity of Type II but not Type I striatal neurons is correlated with recovery of behavioral function after dopamine-depleting brain lesions

1988 • 20 citations

Chapter 15 Chemical transmission in the brain: homeostatic regulation and its functional implications

1994 • 17 citations

Behavioral pharmacology of 6-hydroxydopamine

1973 • 16 citations

Dopaminergic inhibition of striatal GABA release after 6-hydroxydopamine

1996 • 15 citations

Otto Loewi and the demonstration of chemical neurotransmission

1999 • 8 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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