6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

1990 • 2,873 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Progress in Psychobiology and Physiological Psychology

2003 • 1,683 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine

1968 • 862 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Pharmacological actions of 6-hydroxydopamine.

1974 • 792 citations

Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

1986 • 744 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN

1970 • 653 citations

Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study

1988 • 649 citations

Animal models in psychiatry and neurology

1978 • 648 citations

6-Hydroxydopamine and catecholamine neurons

1971 • 637 citations

Nigrostriatal bundle damage and the lateral hypothalamic syndrome.

1974 • 632 citations

Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

1995 • 613 citations

Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin

1990 • 547 citations

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.

1996 • 544 citations

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

1971 • 535 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis

1991 • 507 citations

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

1980 • 498 citations

Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

1970 • 486 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

1990 • 469 citations

THE CONTRIBUTIONS OF MOTOR CORTEX, NIGROSTRIATAL DOPAMINE AND CAUDATE-PUTAMEN TO SKILLED FORELIMB USE IN THE RAT

1986 • 454 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

1969 • 421 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

Striatal D₂ receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with ¹¹C‐raclopride and positron emission tomography

1992 • 395 citations

The neurochemistry of Parkinson's disease: effect of L-dopa therapy.

1975 • 386 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

RECOVERY OF FUNCTION AFTER DAMAGE TO CENTRAL CATECHOLAMINE-CONTAINING NEURONS: A NEUROCHEMICAL MODEL FOR THE LATERAL HYPOTHALAMIC SYNDROME

1976 • 357 citations

Neurochemical Compensation After Nigrostriatal Bundle Injury in an Animal Model of Preclinical Parkinsonism

1984 • 340 citations

Effects ofl-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats

1990 • 334 citations

Injection of solutions into cerebral tissue: Relation between volume and diffusion

1966 • 329 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

1972 • 296 citations

Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system

1973 • 295 citations

Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome

1973 • 292 citations

D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons

1995 • 291 citations

NMDA antagonists potentiate antiparkinsonian actions of <scp>L</scp>‐dopa in monoamine‐depleted rats

1990 • 285 citations

G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase

1993 • 255 citations

Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1973 • 251 citations

Projections of substance P containing neurons from neostriatum to substantia nigra

1977 • 249 citations

A 6-hydroxydopamine-induced selective parkinsonian rat model

1989 • 241 citations

Enhancement of Dopamine-Stimulated Adenylate Cyclase Activity in Rat Caudate after Lesions in Substantia Nigra: Evidence for Denervation Supersensitivity

1974 • 228 citations

Effects of 6-Hydroxydopamine on Noradrenaline-containing Neurones in the Rat Brain

1969 • 223 citations

Effect of 6-hydroxydopamine and some other compounds on the concentration of norepinephrine in the hearts of mice.

1963 • 217 citations

Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

1989 • 215 citations

Striatal grafts in rats with unilateral neostriatal lesions—III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching

1988 • 215 citations

Animal models in psychiatry and neurology

1977 • 213 citations

Pre- and Postsynaptic Neurotoxic Effects of Dopamine Demonstrated by Intrastriatal Injection

1993 • 204 citations

The Pharmacology of 6-Hydroxydopamine

1973 • 199 citations

Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats

1987 • 195 citations

Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications

1989 • 194 citations

Comparison of Dopamine Uptake in the Basolateral Amygdaloid Nucleus, Caudate‐Putamen, and Nucleus Accumbens of the Rat

1995 • 187 citations

Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.

1974 • 187 citations

Oxygen radicals as key mediators in neurological disease: Fact or fiction?

1992 • 186 citations

Modification of Dopamine Transporter Function: Effect of Reactive Oxygen Species and Dopamine

1996 • 183 citations

Unilateral lesion of the nigrostriatal pathway decreases the firing rate and alters the firing pattern of globus pallidus neurons in the rat

1988 • 183 citations

Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions

1987 • 182 citations

Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions.

1976 • 180 citations

Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study

1972 • 179 citations

[ ¹¹ C]raclopride and positron emission tomography in previously untreated patients with Parkinson's disease

1994 • 175 citations

Neurophysiology of Dopaminergic Systems: Current Status and Clinical Perspectives

1987 • 165 citations

Dopamine receptor changes following destruction of the nigrostriatal pathway: Lack of a relationship to rotational behavior

1981 • 164 citations

Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome.

1975 • 163 citations

Time Course of Adaptations in Dopamine Biosynthesis, Metabolism, and Release Following Nigrostriatal Lesions: Implications for Behavioral Recovery from Brain Injury

1987 • 160 citations

Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes.

1996 • 159 citations

Injection of 6-hydroxydopamine into the substantia nigra of the rat. II. Diffusion and specificity

1973 • 159 citations

SIMPLE AND CHOICE REACTION TIME PERFORMANCE FOLLOWING UNILATERAL STRIATAL DOPAMINE DEPLETION IN THE RAT

1991 • 158 citations

Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms

1995 • 157 citations

Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration

1973 • 157 citations

γ‐Aminobutyric Acid and Benzodiazepine Receptor Changes Induced by Unilateral 6‐Hydroxydopamine Lesions of the Medial Forebrain Bundle

1985 • 156 citations

Selective D1 and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions

1987 • 156 citations

Growth of Pulmonary Alveolar Macrophages in vitro

1973 • 155 citations

D₁ and D₂ Dopaminergic Regulation of Acetylcholine Release from Striata of Freely Moving Rats

1990 • 152 citations

Deficits in instrumental responding after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection

1974 • 149 citations

Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage

1988 • 149 citations

Further studies on the generation of hydrogen peroxide by 6-hydroxydopamine. Potentiation by ascorbic acid.

1972 • 146 citations

Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway

1993 • 146 citations

Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats

1991 • 144 citations

Increased dopamine efflux from striatal slices during development and after nigrostriatal bundle damage

1987 • 143 citations

Neostriatal enkephalin-immunoreactive neurones project to the globus pallidus

1982 • 140 citations

Dopamine efflux from striatal slices after intracerebral 6-hydroxydopamine: evidence for compensatory hyperactivity of residual terminals.

1990 • 136 citations

Sensory inattention in rats with 6-hydroxydopamine-induced degeneration of ascending dopaminergic neurons: Apomorphine-induced reversal of deficits

1979 • 135 citations

Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study

1973 • 131 citations

Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: Histochemical and neurochemical analysis

1986 • 131 citations

Effects of 6-Hydroxydopamine on CNS Catecholamines, Spontaneous Motor Activity and Amphetamine Induced Hyperactivity in Rats

1970 • 131 citations

CHANGES IN THE DEVELOPMENT OF CENTRAL NOR ADRENALINE NEURONES FOLLOWING NEONATAL ADMINISTRATION OF 6‐HYDROXYDOPAMINE¹

1974 • 129 citations

Ascorbic acid and oxidative inactivation of proteins

1991 • 127 citations

Herabgesetzte Konzentration der Homovanillinsäure im Gehirn von parkinsonkranken Menschen als Ausdruck der Störung des zentralen Dopaminstoffwechsels

1965 • 126 citations

Reactive capacity: A sensitive behavioral marker of movement initiation and nigrostriatal dopamine function

1985 • 125 citations

Compartments in rat dorsal and ventral striatum revealed following injection of 6-hydroxydopamine into the ventral mesencephalon

1991 • 124 citations

Enhanced sensitivity of caudate neurones to microiotophoretic injections of dopamine in 6-hydroxydopamine treated cats

1972 • 121 citations

Striatal neuropeptide Y neurones are under the influence of the nigrostriatal dopaminergic pathway: Immunohistochemical evidence

1986 • 119 citations

Decreased striatal D1 binding density following mesotelencephalic 6-hydroxydopamine injections: an autoradiographic analysis

1989 • 119 citations

Differential response of striatal dopamine and muscarinic cholinergic receptor subtypes to the loss of dopamine

1991 • 117 citations

Evidence for substance P in the striato-nigral tract

1977 • 115 citations

Stress‐induced neurological impairments in an animal model of parkinsonism

1985 • 115 citations

Dopamine release and uptake rates both decrease in the partially denervated striatum in proportion to the loss of dopamine terminals

1997 • 113 citations

I. Parkinson's disease: Studies with an animal model

1984 • 111 citations

6-Hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat

1996 • 109 citations

The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons

1990 • 109 citations

Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat

1990 • 105 citations

The Importance of Graft Placement and Task Complexity for Transplant‐Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats

1990 • 104 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes

1974 • 104 citations

Compensatory Increase in Tyrosine Hydroxylase Activity in Rat Brain After Intraventricular Injections of 6-Hydroxydopamine

1980 • 102 citations

Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems.

1981 • 102 citations

Partial lesions of the nigrostriatal pathway in the rat Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs

1985 • 102 citations

Short and long term changes in tyrosine hydroxylase activity in rat brain after subtotal destruction of central noradrenergic neurons

1981 • 101 citations

Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. I. 6-OHDA lesions of ascending mesencephalic dopaminergic pathways in the rat

1990 • 98 citations

Effects of 6-hydroxydopamine on putative transmitter substances in the central nervous system

1972 • 97 citations

Compensatory responses to nigrostriatal bundle injury

1989 • 95 citations

Time course of the effects of 6‐hydroxydopamine on catecholamine‐containing neurones in rat hypothalamus and striatum

1970 • 94 citations

Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats

1995 • 93 citations

Pharmacological characterization of dopaminergic influence on expression of neuropeptide Y immunoreactivity by rat striatal neurons

1988 • 93 citations

A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats

1973 • 92 citations

Striatal met-enkephalin concentration increases following nigrostriatal denervation

1983 • 92 citations

Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

1980 • 89 citations

Regulation by dopaminergic neurotransmission of dopamine D2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat

1991 • 85 citations

Alterations in consummatory behavior following intracisternal injection of 6-hydroxydopamine

1973 • 84 citations

Altered response to apomorphine in 6-hydroxydopamine-treated rats

1972 • 82 citations

Regional effects of 6-hydroxydopamine on catecholamine containing neurones in rat brain and spinal cord

1970 • 80 citations

Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion

1980 • 78 citations

Evidence for two functionally distinct subpopulations of neurons within the rat striatum

1988 • 77 citations

Modulation of acetylcholine release by D1, D2 dopamine receptors in rat striatum under freely moving conditions

1990 • 74 citations

Short-term effects of dopamine-depleting brain lesions on spontaneous activity of striatal neurons: Relation to local dopamine concentration and behavior

1986 • 70 citations

Dissociation between biochemical and ultrastructural effects of 6-hydroxydopamine in rat brain

1970 • 70 citations

differential effect of systemic administration of bromocriptine andl-DOPA on the release of acetylcholine from striatum of intact and 6-OHDA-treated rats

1993 • 67 citations

Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen

1991 • 64 citations

Paradoxical Kinesia in Parkinsonism Is Not Caused by Dopamine Release

1989 • 62 citations

Apomorphine-induced restoration of drinking to thirst challenges in 6-hydroxydopamine-treated rats

1976 • 61 citations

HOMOVANILLIC ACID AND DIHYDROXYPHENYLACETIC ACID IN THE STRIATUM OF MONKEYS WITH BRAIN LESIONS

1967 • 61 citations

Frequency-Dependent Release of Acetylcholine and Dopamine From Rabbit Striatum: Its Modulation by Dopaminergic Receptors

1983 • 60 citations

Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

1990 • 60 citations

Effects of lesions on somatostatin-like immunoreactivity in the rat striatum

1983 • 60 citations

Denigration and sensorimotor disability induced by ventral tegmental injection of 6-hydroxy-dopamine in the cat

1971 • 59 citations

D2 dopaminergic regulation of striatal preproenkephalin mRNA levels is mediated at least in part through cholinergic interneurons

1992 • 59 citations

Catecholamine metabolite excretion following intraventricular injection of 6-OH-dopamine

1972 • 59 citations

Dopaminergic inhibition of striatal acetylcholine release after 6-hydroxydopamine

1989 • 58 citations

Somatostatin-immunoreactive neurons in the rat striatum: effects of corticostriatal and nigrostriatal dopaminergic lesions

1990 • 57 citations

Neurochemical evidence for denervation supersensitivity: The effect of unilateral substantia nigra lesions on apomorphine-induced increases in neostriatal acetylcholine levels

1974 • 55 citations

Autoradiographic study of striatal D1 and D2 dopamine receptors in 6-OHDA-lesioned rats receiving foetal ventral mesencephalic grafts and chronic treatment withl-DOPA and carbidopa

1992 • 55 citations

Intracranial injections of 6-OHDA. Comparison of catecholamine-depleting effects of different volumes and concentrations

1976 • 54 citations

Time dependent changes in DA uptake sites, D1 and D2 receptor binding and mRNA after 6-OHDA lesions of the medial forebrain bundle in the rat brain

1995 • 53 citations

Dopamine receptor ‘supersensitivity’ occurring without receptor up-regulation

1991 • 52 citations

Temporal dissociation between changes in striatal enkephalin and substance P messenger RNAs following striatal dopamine depletion

1994 • 45 citations

Striatal neuropeptide levels in Parkinson's disease patients

1992 • 45 citations

Degenerative processes after punctate intracerebral administration of 6-hydroxydopamine

1975 • 45 citations

Asymmetrical distribution of neurotensin immunoreactivity following unilateral injection of 6-hydroxydopamine in rat ventral tegmental area (VTA)

1989 • 44 citations

Resistance of central phenylethanolamine-n-methyl transferase containing neurons to 6-hydroxydopamine.

1976 • 44 citations

Substantia nigra unit responses to trigeminal sensory stimulation

1979 • 42 citations

Levodopa and cholinergic hypersensitivity in Parkinson's disease

1972 • 42 citations

Destruction of the nigrostriatal pathway increases Fos-like immunoreactivity predominantly in striatopallidal neurons

1993 • 41 citations

Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum

1975 • 41 citations

The effects of chronic continuous versus intermittent levodopa treatments on striatal and extrastriatal D1 and D2 dopamine receptors and dopamine uptake sites in the 6-hydroxydopamine lesioned rat — an autoradiographic study

1994 • 41 citations

Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra

1989 • 41 citations

Striatal G-proteins: Effects of unilateral 6-hydroxydopamine lesions

1994 • 40 citations

Chronic eticlopride and dopamine denervation induce equal nonadditive increases in striatal D2 receptor density: Autoradiographic evidence against the dual mechanism hypothesis

1991 • 40 citations

Lesions of the dopaminergic nigrostriatal pathway alter preprosomatostatin messenger rna levels in the striatum, the entopeduncular nucleus and the lateral hypothalamus of the rat

1991 • 40 citations

Behavior of Free-Ranging Macaques after Intraventricular 6-Hydroxydopamine

1973 • 39 citations

Dopaminergic and muscarinic regulation of striatal enkephalin and substance P messenger RNAs following striatal dopamine denervation: Effects of systemic and central administration of quinpirole and scopolamine

1994 • 39 citations

Tremor at rest episodes in unilaterally 6-OHDA-induced substantia nigra lesioned rats: EEG-EMG and behavior

1986 • 38 citations

Alterations in tyrosine hydroxylase expression following partial lesions of the nigrostriatal bundle

1995 • 38 citations

Bilateral 6‐Hydroxydopamine‐induced Lesion of the Nigrostriatal Dopamine Pathway Reproduces the Effects of Unilateral Lesion on Substance P but not on Enkephalin Expression in Rat Basal Ganglia

1996 • 37 citations

Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the house

1985 • 36 citations

Changes in the retention and metabolism of 3 H-l-norepinephrine in rat brain in vivo after 6-hydroxydopamine pretreatment.

1971 • 35 citations

Drug-induced rotational behaviour following unilateral intracerebral injection of saline-ascorbate solution: neurotoxicity of ascorbic acid and monoamine-independent circling

1979 • 35 citations

Presynaptic Receptors and the Question of Autoregulation of Neurotransmitter Release

1990 • 35 citations

Striatal D1- and D2-dopamine receptor sites are separately detectable in vivo

1987 • 34 citations

6-Hydroxydopamine and striatal acetylcholine levels

1974 • 33 citations

Combined in situ hybridization and immunocytochemistry in the assay of pharmacological effects on tyrosine hydroxylase mRNA concentration

1989 • 33 citations

PRESYNAPTIC RECEPTORS AND THE QUESTION OF AUTOREGULATION OF NEUROTRANSMITTER RELEASE

1990 • 33 citations

Variability among brain regions in the specificity of 6-hydroxydopamine (6-OHDA)-induced lesions

1989 • 32 citations

Local cerebral glucose utilization after D1 receptor stimulation in 6‐OHDA lesioned rats: Effect of sensitization (priming) with a dopaminergic agonist

1993 • 32 citations

Ingestive behavior following damage to central dopamine neurons: implications for homeostasis and recovery of function.

1974 • 32 citations

Neurotransmitter-Selective Brain Lesions

2003 • 31 citations

Current concepts in Parkinson's disease research

1995 • 31 citations

Lesions of the mesotelencephalic dopamine system enhance the effects of selective dopamine D1 and D2 receptor agonists on striatal acetylcholine release

1992 • 31 citations

Operant behavior and catecholamine-containing neurons: Prolonged increase in lever-pressing after 6-hydroxydopamine

1972 • 30 citations

Effect of 6-hydroxydopamine on polymerization of tubulin protection by superoxide dismutase, catalase, or anaerobic conditions

1986 • 29 citations

Effect of lateral hypothalamic lesions on uptake of norepinephrine by brain homogenates.

1971 • 29 citations

Effects of dopamine depletion on the spontaneous activity of type I striatal neurons: Relation to local dopamine concentration and motor behavior

1987 • 28 citations

Overeating after midbrain 6-hydroxydopamine: Prevention by central injection of selective catecholamine reuptake blockers

1982 • 28 citations

Loss of dopamine terminals in the medial prefrontal cortex increased the ratio of DOPAC to DA in tissue of the nucleus accumbens shell: role of stress

1997 • 28 citations

Biochemical changes accompanying unilateral 6-hydroxydopamine lesions in the rat substantia nigra

1978 • 28 citations

Long-term effects of human-to-rat mesencephalic xenografts on rotational behavior, striatal dopamine receptor binding, and mRNA levels

1995 • 26 citations

Motor impairments and neurochemical changes after unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic system in monkeys

1990 • 25 citations

Dopamine receptors status after unilateral nigral 6-OHDA lesion

1993 • 25 citations

Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants

1991 • 24 citations

Microspectrofluorimetric analysis of the formaldehyde induced fluorescence in midbrain raphe neurons.

1975 • 21 citations

Gastrointestinal motility and body weight gain in rats after brain serotonin depletion by 5,7-dihydroxytryptamine

1978 • 17 citations

Histopathological changes associated with the intracerebral injection of 6-hydroxydopamine (6-OHDA) and peroxide (H2O2) in the cat and the rat

1975 • 17 citations

Behavioral pharmacology of 6-hydroxydopamine

1973 • 16 citations

Dopamine receptors and cholinergic neurons in the rat neostriatum.

1975 • 15 citations

Dopaminergic inhibition of striatal GABA release after 6-hydroxydopamine

1996 • 15 citations

Brain Lesions: Induction, Analysis, and the Problem of Recovery of Function

1978 • 14 citations

A fetal nigral graft prevents behavioral supersensitivity associated with repeated injections ofl-dopa in 6-ohda rats. Correlation with D1 and D2 receptors

1993 • 13 citations

Partial selectivity of 6-OHDA induced neuronal degeneration after intratissular injection in the brain with special reference to the nigro-striatal dopamine system

1975 • 13 citations

Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.

1986 • 13 citations

Comparison of behavioral changes in cats treated with intracerebroventricular 6-hydroxydopamine and reserpine

1981 • 13 citations

Selective subregional dopamine depletions in the rat caudate‐putamen following nigrostriatal lesions

1992 • 12 citations

The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging

1988 • 11 citations

6-Hydroxydopamine and Aggression in Cats

1981 • 11 citations

BEHAVIOURAL PHARMACOLOGY OF 6-HYDROXYDOPAMINE

1973 • 9 citations

Excitatory Amino Acid Receptor Involvement in the Regulation of Striatal Extracellular Dopamine

1990 • 8 citations

Biochemical pharmacology of brain amine mechanisms.

1975 • 7 citations

Chemical neurotransmission in the parkinsonian brain.

1987 • 7 citations

6-Hydroxydopamine induced degeneration of noradrenaline neurons in the scorbutic guinea-pig

1974 • 6 citations

A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects

1996 • 5 citations

Deficits in the Activation and Phosphorylation of Hippocampal Tyrosine Hydroxylase in the Aged Fischer 344 Rat Following Intraventricular Administration of 6‐Hydroxydopamine

1994 • 5 citations

Deleted Work

1955 • 0 citations