Inhibition of β2 Integrin Receptor and Syk Kinase Signaling in Monocytes by the Src Family Kinase Fgr

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

1999 • 1,228 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

1997 • 451 citations

Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection

1998 • 427 citations

Structure and function of the cytoplasmic domain of band 3: center of erythrocyte membrane—peripheral protein interactions

1986 • 412 citations

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

1994 • 391 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1994 • 346 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant mice

1997 • 270 citations

Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

1999 • 257 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

2000 • 246 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

1994 • 232 citations

Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck

1999 • 231 citations

Integrin-mediated Tyrosine Phosphorylation and Cytokine Message Induction in Monocytic Cells

1995 • 228 citations

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.

1995 • 222 citations

Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5

1987 • 209 citations

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals

1998 • 206 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.

1994 • 174 citations

Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr

1998 • 164 citations

Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function

2000 • 160 citations

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

1999 • 154 citations

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages

1999 • 149 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling

1993 • 137 citations

Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen.

1997 • 136 citations

Integrin signal transduction in myeloid leukocytes

1999 • 134 citations

syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

1997 • 134 citations

Syk- and Lyn-Dependent Phosphorylation of Syk on Multiple Tyrosines Following B Cell Activation Includes a Site That Negatively Regulates Signaling

1998 • 133 citations

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

1997 • 120 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.

1989 • 108 citations

Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly

1996 • 100 citations

Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

2000 • 98 citations

The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages

1998 • 92 citations

Mutations in the Activation Loop Tyrosines of Protein Tyrosine Kinase Syk Abrogate Intracellular Signaling But Not Kinase Activity

1998 • 71 citations

Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk

2000 • 68 citations

Inhibition of cell adhesion by microspheres coated with recombinant soluble intercellular adhesion molecule-1.

1993 • 64 citations

Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages

1991 • 56 citations

Differential expression and regulation of the c-src and c-fgr protooncogenes in myelomonocytic cells.

1987 • 47 citations

Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells.

1989 • 36 citations

The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo

1995 • 18 citations

Characterization of activated lymphocyte-tumor cell adhesion

2000 • 18 citations