Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Mechanism and role of PDZ domains in signaling complex assembly

2001 • 819 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Activation of the HIV-1 LTR by T Cell Mitogens and the Trans-Activator Protein of HTLV-I

1987 • 460 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

High Rate of HTLV-II Infection in Seropositive IV Drug Abusers in New Orleans

1989 • 426 citations

In vivo cellular tropism of human T-cell leukemia virus type 1

1990 • 425 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

1995 • 364 citations

Prevalence of Antibodies to HTLV-I, -II, and -III in Intravenous Drug Abusers From an AIDS Endemic Region

1986 • 340 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

Protein modules as organizers of membrane structure

1999 • 311 citations

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

1985 • 283 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

Chronic neurodegenerative disease associated with HTLV-II infection

1992 • 277 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase

2000 • 267 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

In Vivo Infection of Human T-Cell Leukemia Virus Type I in Non-T Cells

1993 • 226 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

Induction of Bcl-x_LExpression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax

1999 • 214 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Molecular characterization of genome of a novel human T-cell leukaemia virus

1983 • 196 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama.

1990 • 184 citations

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

1998 • 184 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth.

1988 • 169 citations

Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins

1996 • 167 citations

Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB

1996 • 166 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 162 citations

Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8⁺ T cells in cerebrospinal fluid from patients with HAM/TSP

2001 • 141 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Stimulation of Cyclin-Dependent Kinase Activity and G₁- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1998 • 133 citations

Repression of Bax Gene Expression by the HTLV-I Tax Protein: Implications for Suppression of Apoptosis in Virally Infected Cells

1997 • 131 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

Infection of human endothelial cells by human T-lymphotropic virus type I.

1984 • 131 citations

HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II-infected blood donors

1997 • 130 citations

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

1994 • 129 citations

Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1.

1996 • 128 citations

Functional Role of pX Open Reading Frame II of Human T-Lymphotropic Virus Type 1 in Maintenance of Viral Loads In Vivo

2000 • 127 citations

LOW PREVALENCE IN THE UK OF HTLV-I AND HTLV-II INFECTION IN SUBJECTS WITH AIDS, WITH EXTENDED LYMPHADENOPATHY, AND AT RISK OF AIDS

1984 • 125 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

1999 • 122 citations

Construction and Characterization of Infectious Human T-Cell Leukemia Virus Type 1 Molecular Clones

1994 • 120 citations

Down-regulation of the INK4 Family of Cyclin-Dependent Kinase Inhibitors by Tax Protein of HTLV-1 through Two Distinct Mechanisms

1999 • 119 citations

In vivo cellular tropism of human T cell leukemia virus type II (HTLV-II).

1992 • 112 citations

Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples

2000 • 108 citations

Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.

1992 • 106 citations

X-I and X-II Open Reading Frames of HTLV-I Are Not Required for Virus Replication or for Immortalization of Primary T-Cellsin Vitro

1997 • 106 citations

High frequency of human T-cell leukemia-lymphoma virus type II infection in New Mexico blood donors: determination by sequence- specific oligonucleotide hybridization

1990 • 104 citations

Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB

1995 • 101 citations

Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

1994 • 97 citations

Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response

2003 • 93 citations

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line

2003 • 92 citations

Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins

1989 • 92 citations

NF-κB Signaling Pathway Governs TRAIL Gene Expression and Human T-cell Leukemia Virus-I Tax-induced T-cell Death

2001 • 92 citations

Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.

1994 • 92 citations

HTLV-I and HTLV-II Tax: Differences in Induction of Micronuclei in Cells and Transcriptional Activation of Viral LTRs

1996 • 90 citations

Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein

1995 • 89 citations

The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes

1996 • 88 citations

HTLV-II Infection in Florida Indians

1993 • 88 citations

HTLV-II Seroprevalence in Pygmies Across Africa Since 1970

1993 • 88 citations

Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

2003 • 87 citations

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes

1998 • 86 citations

Human T-Cell Leukemia Virus Type 1 Tax Protein Abrogates Interleukin-2 Dependence in a Mouse T-Cell Line

1999 • 86 citations

Immunologic Characterization of Hairy Cell Leukemias in Continuous Culture

1978 • 84 citations

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

1997 • 82 citations

A 10-Amino Acid Domain within Human T-cell Leukemia Virus Type 1 and Type 2 Tax Protein Sequences Is Responsible for Their Divergent Subcellular Distribution

2004 • 81 citations

Immediate effects of reversible HTLV-ITax function: T-cell activation and apoptosis

1995 • 81 citations

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis

2002 • 80 citations

Overexpression of p21 ^waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2

2000 • 80 citations

Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30 ^II Is Required for In Vivo Replication: Evidence of In Vivo Reversion

2004 • 79 citations

The Human T-cell leukemia virus Rex protein

2005 • 79 citations

Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein.

1990 • 76 citations

Functional Relation Between HTLV-II x and Adenovirus E1A Proteins in Transcriptional Activation

1985 • 75 citations

Junctional protein MAGI-3 interacts with receptor tyrosine phosphataseβ (RPTPβ) and tyrosine-phosphorylated proteins

2003 • 75 citations

Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax

1997 • 73 citations

Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells

1995 • 72 citations

MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap

2004 • 72 citations

Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax

2002 • 71 citations

Quantitative studies of the effect of HTLV-I Tax protein on CREB protein - DNA binding

1994 • 68 citations

CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

2001 • 63 citations

Accelerated G1 Phase Progression Induced by the Human T Cell Leukemia Virus Type I (HTLV-I) Tax Oncoprotein

2001 • 61 citations

Human T Cell Leukemia Virus-I (HTLV-I) Tax-Mediated Apoptosis in Activated T Cells Requires an Enhanced Intracellular Prooxidant State

1998 • 61 citations

Genetic Characterization of Transactivation of the Human T-Cell Leukemia Virus Type 1 Promoter: Binding of Tax to Tax-Responsive Element 1 Is Mediated by the Cyclic AMP-Responsive Members of the CREB/ATF Family of Transcription Factors

1996 • 57 citations

Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFκB or CREB/ATF Activation Fail To Transform Primary Human T Cells

2000 • 56 citations

Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor.

1995 • 55 citations

Distinct p300-Responsive Mechanisms Promote Caspase-Dependent Apoptosis by Human T-Cell Lymphotropic Virus Type 1 Tax Protein

2000 • 55 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype.

1992 • 54 citations

Tumours derived from HTLV-Itax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression

1998 • 54 citations

Human T Lymphotropic Virus Type II (HTLV-II) Infection in a Cohort of New York Intravenous Drug Users: An Old Infection?

1991 • 53 citations

Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV- I) tax and HTLV-II tax proteins

1993 • 53 citations

Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes

1996 • 53 citations

Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses

1995 • 52 citations

Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation

1995 • 52 citations

Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function

2000 • 49 citations

The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells

2003 • 49 citations

Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53

2001 • 48 citations

Activation of cyclin D1 and D2 promoters by human T‐cell leukemia virus type I tax protein is associated with IL‐2–independent growth of T cells

2002 • 47 citations

Mutational analysis of human T-cell leukemia virus type 2 Tax

1997 • 47 citations

Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3

2004 • 46 citations

Chimeric proteins composed of Jun and CREB define domains required for interaction with the human T-cell leukemia virus type 1 Tax protein

1995 • 44 citations

Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway

2000 • 44 citations

Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples

2000 • 44 citations

Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Tax Oncoproteins Modulate Cell Cycle Progression and Apoptosis

2004 • 43 citations

The Human T Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein Represses MyoD-dependent Transcription by Inhibiting MyoD-binding to the KIX Domain of p300

2000 • 43 citations

A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo

1996 • 40 citations

Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein

1993 • 39 citations

Tax and Overlapping Rex Sequences Do Not Confer the Distinct Transformation Tropisms of Human T-Cell Leukemia Virus Types 1 and 2

2003 • 37 citations

Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2_pan-p) Transform T Cells Independently of Jak/STAT Activation

1998 • 37 citations

Activation of Bcl-2 Expression in Human Endothelial Cells Chronically Expressing the Human T-Cell Lymphotropic Virus Type I

1997 • 36 citations

Prevalence of antibodies to HTLV-I, -II, and -III in intravenous drug abusers from an AIDS endemic region

1986 • 34 citations

Neurologic consequences of HTLV-II infection in injection-drug users

1996 • 33 citations

Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34 ⁺ Cells In Vitro

2003 • 32 citations

NF-κB activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I

1991 • 30 citations

In VitroCellular Tropism of Human T Cell Leukemia Virus Type 2

2000 • 28 citations

Infection with human T-lymphotropic viruses leads to constitutive expression of leukemia inhibitory factor and interleukin-6

1993 • 28 citations

Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein

2003 • 27 citations

Block of a Mitochondrial-Mediated Apoptotic Pathway in Tax-Expressing Murine Fibroblasts

2001 • 25 citations

Comparison of CREB- and NF-κB-Mediated Transactivation by Human T Lymphotropic Virus Type II (HTLV-II) and Type I (HTLV-I) Tax Proteins

2002 • 25 citations

Infectivity of human T-lymphotropic virus type I to human nervous tissue cells in vitro

1992 • 24 citations

Over expression of insulin-like growth factor receptor type-I in T-cell lines infected with human T-lymphotropic virus types-I and -II

1993 • 20 citations

Molecular epidemiology of HTLV-2 infection among intravenous drug users in Spain

2004 • 20 citations

HTLV-I induced myeloneuropathy in WKAH rats: apoptosis and local activation of the HTLV-I pX and TNF-alpha genes implicated in the pathogenesis.

1997 • 17 citations

Tax responsiveness of the GM-CSF promoter is mediated by mitogen-inducible sequences other than kappa B.

1991 • 16 citations

Resistance to Fas-Mediated Apoptosis of Human T-Cell Lines Expressing Human T-Lymphotropic Virus Type-2 (HTLV-2) Tax Protein

2001 • 15 citations

Transformation of CD8 + T‐Cells Producing a Strong Cytopathic Effect on CD4+ T‐Cells through Syncytium Formation by HTLV‐II

1991 • 13 citations

Kinetic Analysis of Human T-cell Leukemia Virus Type I Tax-Mediated Activation of NF-κB

1994 • 12 citations

Infection with human T-lymphotropic viruses leads to constitutive expression of leukemia inhibitory factor and interleukin-6

1993 • 3 citations

Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV- I) tax and HTLV-II tax proteins

1993 • 3 citations

High frequency of human T-cell leukemia-lymphoma virus type II infection in New Mexico blood donors: determination by sequence- specific oligonucleotide hybridization

1990 • 2 citations