Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

The inducible transcription factor NF-κB: structure-function relationship of its protein subunits

1993 • 429 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Elicitors of Plant Defense Responses

1994 • 387 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

1990 • 330 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.

1992 • 288 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

1993 • 258 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat

1989 • 239 citations

Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.

1992 • 237 citations

Preparation of Nuclear and Cytoplasmic Extracts from Mammalian Cells

2006 • 227 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

1991 • 188 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

1994 • 178 citations

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.

1993 • 177 citations

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

1992 • 171 citations

Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth.

1988 • 169 citations

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

1993 • 155 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

c-rel activates but v-rel suppresses transcription from kappa B sites.

1991 • 146 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box.

1993 • 129 citations

Subcellular Localization of the Product of the Long Open Reading Frame of Human T-Cell Leukemia Virus Type I

1985 • 128 citations

Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.

1993 • 121 citations

Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein

1992 • 116 citations

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

1991 • 116 citations

Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.

1994 • 109 citations

A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization

1993 • 107 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

The indirect association of human T-cell leukemia virus tax protein with DNA results in transcriptional activation

1991 • 97 citations

Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins

1989 • 92 citations

Electroporation: application to human lympboid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type I

1989 • 88 citations

Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells

1992 • 87 citations

Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein.

1990 • 76 citations

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.

1992 • 71 citations

NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

1993 • 68 citations

Binding of the HTLV-I Tax1 transactivator to the inducible 21 bp enhancer is mediated by the cellular factor HEB1.

1991 • 66 citations

Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.

1994 • 63 citations

Heat-shock Induction of the Human Immunodeficiency Virus Long Terminal Repeat

1988 • 41 citations

Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein

1993 • 39 citations

Association of the pX gene product of human T-cell leukemia virus type-I with nucleus

1985 • 38 citations

Lymphocyte Activation and the Family of NF-κB Transcription Factor Complexes

1992 • 31 citations

NF-κB activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I

1991 • 30 citations

Preparation of Nuclear and Cytoplasmic Extracts from Mammalian Cells

2001 • 21 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 16 citations

A Lymphoid Cell-Specific Nuclear Factor Containing c-Rel-Like Proteins Preferentially Interacts with Interleukin-6 κΒ-Related Motifs Whose Activities Are Repressed in Lymphoid Cells

1992 • 3 citations