Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV- I) tax and HTLV-II tax proteins

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression

1987 • 1,293 citations

A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

1982 • 1,195 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.

1987 • 533 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.

1988 • 431 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Humoral Hypercalcemia of Cancer

1988 • 362 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

1986 • 282 citations

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

1990 • 229 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun

1990 • 212 citations

Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene.

1990 • 211 citations

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

1990 • 210 citations

Characterization of the human parathyroid hormone-like peptide gene

1989 • 180 citations

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.

1992 • 177 citations

Isolation and characterization of the human parathyroid hormone-like peptide gene.

1989 • 175 citations

The x Gene Is Essential for HTLV Replication

1985 • 161 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

Activation of the GM-CSF promoter by HTLV-I and -II tax proteins.

1989 • 91 citations

Parathyroid Hormone-Related Protein in Adult T-Cell Leukemia-Lymphoma

1989 • 85 citations

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat.

1990 • 81 citations

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene.

1989 • 80 citations

Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with "atypical" hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders

1988 • 78 citations

Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I

1991 • 75 citations

Induction of the HTLV-I LTR by Jun Occurs through the Tax-Responsive 21-bp elements

1991 • 71 citations

HTLV-II Transactivation Is Regulated by the Overlapping tax / rex Nonstructural Genes

1988 • 68 citations

Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements.

1991 • 67 citations

Parathyroid hormone-like peptide shares features with members of the early response gene family: rapid induction by serum, growth factors, and cycloheximide.

1992 • 67 citations

Deregulation of Interleukin-2 Receptor Gene Expression in HTLV-I-Induced Adult T-Cell Leukemia

1985 • 62 citations

Expression of a Zinc Finger Gene in HTLV-I- and HTLV-II-Transformed Cells

1990 • 62 citations

Tumor necrosis factor-beta in the serum of adult T-cell leukemia with hypercalcemia

1991 • 37 citations

Human T-cell leukemia virus type II Rex binding and activity require an intact splice donor site and a specific RNA secondary structure

1991 • 31 citations

Transactivation of the proenkephalin gene promoter by the Tax1 protein of human T-cell lymphotropic virus type I.

1992 • 23 citations

Constitutive expression of c-jun and jun-B in cell lines infected with human T-lymphotropic virus types I and II

1991 • 21 citations

Activation of NF-kappa B by the HTLV-I trans-activator protein Tax requires an additional factor present in lymphoid cells.

1989 • 17 citations