Peptide growth factors in the intestine

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Epidermal growth factor.

1990 • 1,645 citations

Hepatogastroenterology

2012 • 1,367 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Cytokines in context.

1991 • 808 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Receptors for the TGF-β family

1992 • 638 citations

Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

1996 • 498 citations

Cytokines in Inflammatory Bowel Disease

1998 • 481 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

SMADs: mediators and regulators of TGF-β signaling

1998 • 476 citations

Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β

1993 • 446 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

1994 • 420 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1996 • 388 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Regulation of intestinal epithelial cell growth by transforming growth factor type beta.

1989 • 341 citations

Effects of growth factors on an intestinal epithelial cell line: Transforming growth factor β inhibits proliferation and stimulates differentiation

1987 • 305 citations

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

1994 • 276 citations

Fibroblast growth factors modulate intestinal epithelial cell growth and migration

1994 • 266 citations

Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

1991 • 260 citations

Expression of basic fibroblast growth factor in normal human tissues.

1990 • 258 citations

Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats

1996 • 257 citations

Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers

1993 • 230 citations

Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.

1987 • 222 citations

Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.

1989 • 219 citations

Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

1991 • 219 citations

Trefoil peptides: from structure to function

1997 • 217 citations

The Trefoil Peptide Family

1996 • 213 citations

Gastrointestinal mucosal regeneration role of growth factors

1999 • 210 citations

Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.

1992 • 190 citations

Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease

1992 • 190 citations

Growth factors and oncogenes in human gastrointestinal carcinomas

1990 • 185 citations

Growth Factors in Inflammatory Bowel Disease

1999 • 179 citations

Trefoil peptides

1999 • 179 citations

Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.

1996 • 175 citations

Autocrine Secretion—10 Years Later

1992 • 170 citations

Healing the epithelium: Solving the problem from two sides

1997 • 167 citations

Distribution and release of epidermal growth factor in man.

1989 • 161 citations

Localization of transforming growth factor β isoforms in the normal murine small intestine and colon

1993 • 157 citations

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon.

1992 • 151 citations

Intestinal trefoil factor controls the expression of the adenomatous polyposis coli–catenin and the E-cadherin–catenin complexes in human colon carcinoma cells

1998 • 151 citations

Enhanced mucosal cytokine production in inflammatory bowel disease

1992 • 151 citations

FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation

1998 • 149 citations

Epidermal Growth Factor Receptor of the Intestinal Enterocyte

1989 • 146 citations

Hepatocyte Growth Factor/Scatter Factor Modulates Intestinal Epithelial Cell Proliferation and Migration

1994 • 144 citations

Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture.

1995 • 138 citations

Phosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor.

1997 • 137 citations

Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors.

1992 • 137 citations

Expression of transforming growth factor alpha messenger rna in the normal and neoplastic gastro‐intestinal tract

1989 • 132 citations

Transforming growth factor β1 selectively augments collagen synthesis by human intestinal smooth muscle cells

1990 • 111 citations

Insulin-Like Growth Factors and the Developing and Mature Rat Small Intestine: Receptors and Biological Actions

1990 • 110 citations

Regulation of transforming growth factor expression in rat intestinal epithelial cell lines.

1991 • 109 citations

Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract.

1992 • 107 citations

The Role of Epidermal Growth Factor (EGF) and Its Receptor in Mucosal Protection, Adaptation to Injury, and Ulcer Healing: Involvement of EGF-R Signal Transduction Pathways

1998 • 94 citations

Activin A: a novel player and inflammatory marker in inflammatory bowel disease?

1997 • 93 citations

Immunocytochemical localization of basic fibroblast growth factor in carcinomas and inflammatory lesions of the human digestive tract.

1993 • 92 citations

Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides.

2000 • 91 citations

Growth factors and the gastrointestinal tract

1998 • 88 citations

Epithelial Migration in the Colon: Filling in the Gaps

1997 • 84 citations

Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions

1995 • 84 citations

Insulinlike growth factor I and interleukin 1β messenger RNA in a rat model of granulomatous enterocolitis and hepatitis

1993 • 83 citations

Insulin-like Growth Factor-I Partially Attenuates Colonic Damage in Rats with Experimental Colitis Induced by Oral Dextran Sulphate Sodium

1998 • 79 citations

The role of growth factors in gastrointestinal cell proliferation.

1994 • 76 citations

Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta.

1996 • 68 citations

Radioautographic localization of epidermal growth factor receptors in human fetal gut

1991 • 62 citations

Restitution of frog gastric mucosa in vitro: Effect of basic fibroblast growth factor

1993 • 61 citations

Epidermal growth factor promotes rapid response to epithelial injury in rabbit duodenum in vitro

1996 • 61 citations

Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression.

1990 • 60 citations

Identification of basic fibroblast growth factor sensitivity and receptor and ligand expression in human colon tumor cell lines

1992 • 57 citations

Autocrine Regulation of Human Tumor Cell Proliferation by Insulin-Like Growth Factor II: anin-VitroModel*

1990 • 53 citations

Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo

2000 • 51 citations

Epidermal Growth Factor, Epidermal Growth Factor Receptors, Intestinal Growth, and Adaptation

1999 • 49 citations

Effects of urogastrone-epidermal growth factor on intestinal brush border enzymes and mitotic activity.

1991 • 49 citations

Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours

1999 • 46 citations

Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells

2000 • 42 citations

Insulin-like growth factors and inflammatory bowel disease

1996 • 38 citations

FIBROBLAST GROWTH FACTOR 1 AND FIBROBLAST GROWTH FACTOR 2 IMMUNOREACTIVITY IN GASTROINTESTINAL TUMOURS

1997 • 37 citations

PEPTIDE REGULATORY FACTORS: MULTIFUNCTIONAL MEDIATORS OF CELLULAR GROWTH AND DIFFERENTIATION

1989 • 36 citations

Transforming Growth Factor (TGF-β)-specific Signaling by Chimeric TGF-β Type II Receptor with Intracellular Domain of Activin Type IIB Receptor

1997 • 33 citations

Immunolocalization of transforming growth factor-alpha and epidermal growth factor receptor in the rat gastroduodenal area.

1999 • 31 citations

The effects of intracolonic EGF on mucosal growth and experimental carcinogenesis

1991 • 31 citations

Trefoil peptides

1996 • 31 citations

Insulin-Like Growth Factor-1 Modulation of Intestinal Epithelial Cell Restitution

1999 • 29 citations

The major colonic cell mitogen extractable from colonic mucosa is an N terminally extended form of basic fibroblast growth factor

1991 • 29 citations

Transforming growth factor-beta and hepatocyte growth factor plasma levels in patients with inflammatroy bowel disease

2000 • 29 citations

8 Gut hormones, growth and malignancy

1994 • 27 citations

Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.

1999 • 21 citations

Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro.

1991 • 20 citations

Effects of growth factors and gut hormones on proliferation of primary cultured gastric mucous cells of guinea pig

1996 • 19 citations

Hepatocyte Growth Factor Stimulates Fetal Gastric Epithelial Cell Growthin Vitro

1998 • 16 citations

EGF stimulates both cyclooxygenase activity and cell proliferation of cultured guinea pig gastric mucous cells.

1994 • 14 citations

Transforming growth factor-alpha (TGF-alpha) levels in human proximal gastrointestinal epithelium. Effect of mucosal injury and acid inhibition.

1997 • 8 citations

Immunohistochemical localization of basic fibroblast growth factor in the normal adult gastrointestinal tract

1994 • 7 citations

Proliferation of gastrointestinal carcinoma cells by T lymphocyte factors interleukin-3 and granulocyte-macrophage colony-stimulating factor

1991 • 6 citations

Activin a modulates intestinal epithelial cell function in vitro

2000 • 2 citations