Growth factors and oncogenes in human gastrointestinal carcinomas

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Growth Factors and Cancer

1991 • 2,044 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation

1985 • 446 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Expression of epidermal growth factor receptor in human gastric and colonic carcinomas.

1988 • 365 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Alfred P. Sloan Jr. prize. Studies and prospectives of the protein kinase C family for cellular regulation

1989 • 298 citations

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

1986 • 277 citations

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

1988 • 251 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Immunocytochemical localization of human epidermal growth factor/urogastrone in several human tissues.

1985 • 235 citations

Growth factor production by human colon carcinoma cell lines.

1989 • 186 citations

Characterization and Chromosome Assignment of the Human Homolog of int-2, a Potential Proto-Oncogene

1986 • 178 citations

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

1987 • 178 citations

Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma

1988 • 177 citations

Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1.

1985 • 170 citations

High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.

1989 • 162 citations

Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene.

1986 • 149 citations

Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines.

1988 • 148 citations

Clinical significance of gastrin receptors in human colon cancers.

1989 • 147 citations

High incidence of egf receptor hyperproduction in esophageal squamous‐cell carcinomas

1987 • 142 citations

Heterodimeric transforming growth factor beta. Biological properties and interaction with three types of cell surface receptors.

1988 • 138 citations

Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancers.

1988 • 133 citations

The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.

1989 • 114 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin

1989 • 110 citations

Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.

1988 • 107 citations

Expression of TGF‐β and procollagen type I and type III in human gastric carcinomas

1989 • 99 citations

Amplification of epidermal growth factor receptor (EGFR) gene and oncogenes in human gastric carcinomas

1989 • 98 citations

A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-rasoncogene

1986 • 93 citations

Isolation of the Oncogene and Epidermal Growth Factor-Induced Transin Gene: Complex Control in Rat Fibroblasts

1986 • 90 citations

Immunocytochemical localization of epidermal growth factor in the developing human respiratory system and in acute and chronic lung disease in the neonate.

1989 • 84 citations

Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.

1984 • 81 citations

Site-Selective 8 -Chloro- Cyclic Adenosine 3′,5′-Monophosphate as a Biologic Modulator of Cancer: Restoration of Normal Control Mechanisms

1989 • 81 citations

Binding of gastrin(17) to human gastric carcinoma cell lines.

1988 • 80 citations

Regulation of the gastrin promoter by epidermal growth factor and neuropeptides.

1989 • 70 citations

Estrogen receptors in gastric adenocarcinoma: A retrospective immunohistochemical analysis

1988 • 70 citations

Selective killing of squamous carcinoma cells by an immunotoxin that recognizes the egf receptor

1989 • 66 citations

Clonal allele loss in gastrointestinal cancers

1989 • 55 citations

Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C.

1987 • 55 citations

The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21.

1988 • 49 citations

Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line.

1987 • 47 citations

hst-1 transforming protein: expression in silkworm cells and characterization as a novel heparin-binding growth factor.

1988 • 44 citations

AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS

1988 • 42 citations

Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.

1986 • 41 citations

A structure and some function

1988 • 39 citations

Gastrin and the transforming protein of polyoma virus have evolved from a common ancestor

1982 • 38 citations

The expression of the platelet-derived and transforming growth factor genes in human nonsmall lung cancer cell lines is related to tumor stroma formation in nude mice tumors.

1988 • 35 citations

Infrequent loss of chromosomal heterozygosity in human stomach cancer.

1988 • 34 citations

Interaction between Transforming Growth Factor-Alpha and c-Ha-ras p21 in Progression of Human Gastric Carcinoma

1988 • 32 citations

Two homologous oncogenes, HST1 and INT2, are closely located in human genome

1988 • 32 citations

Epidermal Growth Factor Induces the Expression of Its Receptor Gene in Human Gastric Carcinoma Cell Line TMK‐1

1989 • 31 citations

Phosphorylation of a synthetic gastrin peptide by the tyrosine kinase of A431 cell membranes

1982 • 30 citations

Effect of gastrin on gastric mucosal cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity in rat stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.

1985 • 30 citations

Transforming growth factors: sources, properties and possible roles in normal and malignant cell growth control

1984 • 30 citations

Mechanism of activation of human ras genes cloned from a gastric adenocarcinoma and a pancreatic carcinoma cell line.

1986 • 28 citations

Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas

1989 • 27 citations

Effect of Human Epidermal Growth Factor on Cell Growth and Its Receptor in Human Gastric Carcinoma Cell Lines

1988 • 24 citations

Studies and prospectives of the protein kinase C family for cellular regulation.

1989 • 24 citations

Endocrine Tumors of the Gastrointestinal Tract: Classification, Function and Biological Behavior

1988 • 20 citations

<italic>HST</italic>1 and <italic>INT</italic>2 Gene Coamplification in a Squamous Cell Carcinoma of the Gallbladder

1989 • 17 citations

Epidermal Growth Factor Receptor‐mediated Selective Cytotoxicity of Antitumor Agents toward Human Xenografts and Murine Syngeneic Solid Tumors

1989 • 15 citations

Cholecystokinin inhibition of tumor growth and gastrin-stimulated cyclic adenosine 3':5'-monophosphate metabolism in human gastric carcinoma in nude mice.

1986 • 15 citations

Molecular Cloning of Gene Sequences Regulated by Tumor Promoters and Mitogens through Protein Kinase C

1987 • 13 citations

Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.

1985 • 12 citations

Gastrin receptors in human gastric scirrhous carcinoma

1988 • 12 citations

Morphological changes in a human scirrhous gastric carcinoma cell line (KATO-III) when cultured in collagen-coated dishes

1988 • 8 citations

Tumour suppressor genes: Oncogenesis update

1989 • 8 citations

Structural Relationships Between Growth Factor Precursors and Cell Surface Receptors

1986 • 8 citations

The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1.

1989 • 6 citations

[Gastric scirrhous carcinoma and growth factors].

1988 • 4 citations

[Oncogenes in human gastric carcinoma].

1989 • 4 citations