Intestinal trefoil factor controls the expression of the adenomatous polyposis coli–catenin and the E-cadherin–catenin complexes in human colon carcinoma cells

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Antibodies to major histocompatibility antigens produced by hybrid cell lines

1977 • 1,727 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

Adhesion in cell migration

1995 • 520 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

β-Catenin mutations in cell lines established from human colorectal cancers

1997 • 483 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

1994 • 420 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Signal transduction by β-catenin

1995 • 398 citations

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.

1992 • 337 citations

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

1992 • 323 citations

The APC Protein and E-cadherin Form Similar but Independent Complexes with α-Catenin, β-Catenin, and Plakoglobin

1995 • 315 citations

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

1995 • 290 citations

Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

1991 • 272 citations

Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin

1997 • 260 citations

Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease

1993 • 256 citations

Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration

1995 • 252 citations

Catenins as mediators of the cytoplasmic functions of cadherins

1993 • 249 citations

Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival

1997 • 243 citations

Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach

1995 • 179 citations

Adhesion molecules: Novel molecular tools in tumor pathology

1994 • 173 citations

hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus.

1993 • 164 citations

Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps.

1997 • 161 citations

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

1996 • 142 citations

Phosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor.

1997 • 137 citations

Genetic steps in colorectal cancer

1994 • 132 citations

Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease

1998 • 130 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein

1997 • 124 citations

Ultrastructure of cell loss in intestinal mucosa

1977 • 116 citations

Combined Intestinal Trefoil Factor and Epidermal Growth Factor is Prophylactic against Indomethacin-Induced Gastric Damage in the Rat

1995 • 112 citations

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

1997 • 108 citations

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells

1992 • 105 citations

Intestinal trefoil factor (TFF 3) and pS2 (TFF 1), but not spasmolytic polypeptide (TFF 2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium

1997 • 105 citations

Response of colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene.

1995 • 96 citations

The kinetics of villus cell populations in the mouse small intestine.

1982 • 93 citations

Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel

1995 • 85 citations

Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.

1996 • 83 citations

Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence.

1996 • 63 citations

Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor

1995 • 59 citations

Characterization of a Putative Receptor for Intestinal Trefoil Factor in Rat Small Intestine: Identification byin SituBinding and Ligand Blotting

1997 • 55 citations

Molecular and cellular analysis of rP1.B in the rat hypothalamus: In situ hybridization and immunohistochemistry of a new P-domain neuropeptide

1995 • 40 citations

Expression and purification of a trefoil peptide motif in a β‐galactosidase fusion protein and its use to search for trefoil‐binding sites

1993 • 39 citations

Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression.

1997 • 30 citations

A sensitive micro-immunoassay using β-galactosidase/ anti-β-galactosidase complexes

1987 • 29 citations

Modulation of cell adhesion during epithelial restitution in the gastrointestinal tract.

1996 • 16 citations