Autocrine Regulation of Human Tumor Cell Proliferation by Insulin-Like Growth Factor II: anin-VitroModel*

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II

1984 • 326 citations

Insulin-Like Growth Factor I (IGF-I)-Binding Protein Complex Is a Better Mitogen than Free IGF-I*

1989 • 318 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins

1980 • 250 citations

Insulin-Like Growth Factor-ll (IGF-II): A Potential Autocrine/Paracrine Growth Factor for Human Breast Cancer Acting via the IGF-I Receptor

1989 • 248 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

1987 • 240 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Affinity Chromatography and Purification of the Insulin Receptor of Liver Cell Membranes

1972 • 219 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

1989 • 188 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

1984 • 145 citations

An Autocrine/Paracrine Role forInsulin-Like Growth Factors inthe Regulation ofHuman Placental Growth*

1986 • 133 citations

Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.

1988 • 121 citations

IGF-2 stimulated growth mediated by the somatomedin type 2 receptor

1987 • 121 citations

Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation.

1989 • 116 citations

The Effect of Solubilization on the Properties of the Insulin Receptor of Human Placental Membranes*

1978 • 106 citations

Tissue and Plasma Somatomedin-C/Insulin-Like Growth Factor I Concentrations in the Human Fetus during the First Half of Gestation

1986 • 102 citations

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors

1987 • 89 citations

Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

1983 • 85 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

Incorporation of [³H]thymidine by isolated fetal myoblasts and fibroblasts in response to human placental lactogen (HPL): Possible mediation of HPL action by release of immunoreactive SM‐C

1985 • 71 citations

Heterogeneity of insulin-like growth factor-I affinity for the insulin-like growth factor-II receptor: Comparison of natural, synthetic and recombinant DNA-derived insulin-like growth factor-I

1987 • 64 citations

Release of Insulin-Like Growth Factors and Binding Protein Activity into Serum-Free Medium of Cultured Human Fibroblasts*

1984 • 62 citations

MEASUREMENT OF INSULIN‐LIKE GROWTH FACTOR‐II BY RADIORECEPTOR ASSAY USING OVINE PLACENTAL MEMBRANES

1986 • 59 citations

Somatomedin-C in Human Fetal Pancreas: Cellular Localization and Release During Organ Culture

1987 • 50 citations

Production of an insulin-like growth factor by osteosarcoma

1984 • 46 citations

Insulin‐like growth factor II binding and action in human fetal fibroblasts

1987 • 40 citations

Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor

1982 • 39 citations

Autocrine tumour growth regulation by somatomedin C: an in-vitro model

1986 • 30 citations

Identification of receptors for insulin-like growth factor II in two insulin-like growth factor II producing cell lines

1986 • 24 citations

Production of somatomedin-like activity by human adult tumor-derived, transformed, and normal cell cultures and by cultured rat hepatocytes: effects of culture conditions and of epidermal growth factor (urogastrone)

1984 • 14 citations

A new gastric carcinoma cell line (LIM1839) derived from a young caucasian male

1989 • 14 citations

[19] Derivation of monoclonal antibodies to human somatomedin C/insulin-like growth factor I

1987 • 10 citations