Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Chromosomal passengers: conducting cell division

2007 • 789 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Aurora-A: the maker and breaker of spindle poles

2007 • 425 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

Aurora Kinases as Anticancer Drug Targets

2008 • 383 citations

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

2006 • 369 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Chromosomal passengers: the four-dimensional regulation of mitotic events

2004 • 310 citations

Aurora Kinases: New Targets for Cancer Therapy

2006 • 276 citations

Mitotic mechanics: the auroras come into view

2003 • 269 citations

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour

2001 • 267 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

2004 • 265 citations

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

2005 • 252 citations

The GIT-Associated Kinase PAK Targets to the Centrosome and Regulates Aurora-A

2005 • 229 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I

2008 • 167 citations

Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

2005 • 163 citations

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

2002 • 162 citations

Mitotic Activation of the Kinase Aurora-A Requires Its Binding Partner Bora

2006 • 161 citations

Differential Functions of the Aurora-B and Aurora-C Kinases in Mammalian Spermatogenesis

2006 • 160 citations

Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis

2006 • 145 citations

A Microtubule-Independent Role for Centrosomes and Aurora A in Nuclear Envelope Breakdown

2007 • 133 citations

CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage

2005 • 123 citations

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity

2007 • 119 citations

Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680

2007 • 108 citations

Failure To Proliferate and Mitotic Arrest of CDK11^p110/p58-Null Mutant Mice at the Blastocyst Stage of Embryonic Cell Development

2004 • 83 citations

Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality

2008 • 69 citations

The role of Aurora-A inhibitors in cancer therapy

2007 • 67 citations