Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

The Biology of Chronic Myeloid Leukemia

1999 • 1,308 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

2004 • 1,066 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

2002 • 675 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

2005 • 556 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Identification of novel FLT‐3 Asp835 mutations in adult acute myeloid leukaemia

2001 • 381 citations

Mechanism of Aurora B Activation by INCENP and Inhibition by Hesperadin

2005 • 378 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

2006 • 278 citations

A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance

2005 • 227 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase

2002 • 191 citations

The GIST of targeted cancer therapy: A tumor (Gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571)

2002 • 145 citations

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

1998 • 136 citations

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I–cell clones

2002 • 93 citations

Recent developments for the efficient crystallographic refinement of macromolecular structures

1998 • 81 citations

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

2005 • 73 citations

Deleted Work

1955 • 0 citations