RET/ptc and TRK Oncogenes in Papillary Thyroid Carcinoma

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

ras GENES

1987 • 3,818 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

Activation of a novel human transforming gene, ret, by DNA rearrangement

1985 • 796 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Mechanism of met oncogene activation

1986 • 551 citations

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

1979 • 491 citations

The cyclic AMP-mediated stimulation of cell proliferation

1989 • 464 citations

A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

1987 • 413 citations

ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

1987 • 346 citations

High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.

1989 • 272 citations

Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.

1988 • 246 citations

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of ret Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

1993 • 239 citations

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

1992 • 228 citations

Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.

1992 • 224 citations

The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-Dependent protein kinase

1991 • 192 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.

1993 • 168 citations

Oncogenes of Spontaneous and Chemically Induced Tumors

1982 • 152 citations

Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A

1991 • 132 citations

Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells.

1991 • 99 citations

Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas.

1992 • 71 citations

The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10 q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).

1989 • 66 citations

Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas

1992 • 52 citations

Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing.

1989 • 49 citations

The two mRNA forms for the type Iα regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals

1990 • 41 citations

Human TRK proto-oncogene maps to chromosome 1q32-q41.

1990 • 39 citations

Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC.

1991 • 37 citations

The human tropomyosin gene involved in the generation of the TRK oncogene maps to chromosome 1q31.

1991 • 28 citations

Expression of the ETS2 and transferrin receptor genes in Philadelphia‐positive chronic myeloid leukemia patients with a reciprocal t(3;21)

1992 • 21 citations