Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1994 • 702 citations

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

1994 • 646 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

1994 • 531 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function

1990 • 286 citations

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

1988 • 242 citations

The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas.

1990 • 233 citations

Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues.

1995 • 226 citations

Activation of the feline c-fms proto-oncogene: Multiple alterations are required to generate a fully transformed phenotype

1988 • 164 citations

cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily.

1993 • 155 citations

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

1989 • 130 citations

Developmental expression of the RET protooncogene.

1994 • 119 citations

Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells.

1991 • 99 citations

Specific expression of the ret proto-oncogene in human neuroblastoma cell lines.

1990 • 93 citations

Characterization of the ret proto-oncogene products expressed in mouse L cells.

1993 • 88 citations

Human trk Oncogenes Activated by Point Mutation, In-Frame Deletion, and Duplication of the Tyrosine Kinase Domain

1990 • 73 citations

The human protooncogene ret: a communicative cadherin?

1992 • 62 citations

Motifs of cadherin- and fibronectin type III-related sequences and evolution of the receptor-type-protein tyrosine kinases: sequence similarity between proto-oncogene ret and cadherin family.

1993 • 36 citations

Germ Line Mutations of the ret Proto‐oncogene in Japanese Patients with Multiple Endocrine Neoplasia Type 2A and Type 2B

1994 • 11 citations

Specific expression of the ret proto-oncogene in human neuroblastoma cell lines

1994 • 6 citations