Adipose Tissue as an Endocrine Organ

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

2000 • 3,142 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome

2000 • 2,695 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Novel Modulator for Endothelial Adhesion Molecules

1999 • 2,168 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

1996 • 2,082 citations

Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913.

1984 • 1,948 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Leptin

2000 • 1,368 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

From Lesions to Leptin

1999 • 1,165 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Adipose tissue as an endocrine and paracrine organ

1998 • 1,000 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation

2001 • 969 citations

Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma

1996 • 919 citations

Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty

1996 • 886 citations

A Comparison of the Effects of Hydrochlorothiazide and Captopril on Glucose and Lipid Metabolism in Patients with Hypertension

1989 • 870 citations

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1997 • 851 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

2000 • 712 citations

Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1— A Tissue-Specific Amplifier of Glucocorticoid Action¹

2001 • 712 citations

FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family

2000 • 670 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

1998 • 654 citations

The regulation of adipose tissue distribution in humans.

1996 • 652 citations

Human leptin levels are pulsatile and inversely related to pituitary–ardenal function

1997 • 632 citations

Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines · Adipocyte‐derived Bioactive Substances

1999 • 607 citations

Adipose tissue as a source of hormones

1987 • 597 citations

A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation

2001 • 597 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

1997 • 519 citations

Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

2001 • 489 citations

The effects of lesions in the hypothalamus in parabiotic rats

1959 • 465 citations

Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

2001 • 435 citations

Entrainment of the diurnal rhythm of plasma leptin to meal timing.

1997 • 428 citations

The role of TNFα in adipocyte metabolism

1999 • 427 citations

Hypoleptinemia in Women Athletes: Absence of a Diurnal Rhythm with Amenorrhea

1997 • 350 citations

Chemokines control fat accumulation and leptin secretion by cultured human adipocytes

2001 • 333 citations

Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II¹

1998 • 330 citations

Impaired transport of leptin across the blood-brain barrier in obesity☆

1999 • 328 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development*

1999 • 320 citations

Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

1987 • 319 citations

Generalized lipodystrophy, congenital and acquired (lipoatrophy)

1996 • 302 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women

1998 • 271 citations

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation.

1995 • 268 citations

Endocrinologic and metabolic effects of interleukin-6 in humans

1995 • 254 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia¹

1999 • 250 citations

Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.

1992 • 243 citations

What's in a Name? In Search of Leptin's Physiologic Role

1998 • 240 citations

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

1998 • 229 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.

1994 • 197 citations

Angiotensinogen-Deficient Mice Exhibit Impairment of Diet-Induced Weight Gain with Alteration in Adipose Tissue Development and Increased Locomotor Activity

2001 • 184 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II

1998 • 171 citations

Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice

2001 • 170 citations

Obesity and diabetes in TNF-alpha receptor- deficient mice.

1998 • 168 citations

Role of Gonadal Steroids in the Sexual Dimorphisms in Body Composition and Circulating Concentrations of Leptin¹

1999 • 148 citations

Aromatase-deficient (ArKO) mice accumulate excess adipose tissue

2001 • 139 citations

Acylation stimulating protein (ASP), an adipocyte autocrine: new directions

1999 • 129 citations

Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein¹

2000 • 126 citations

Hypoleptinemia in Women Athletes: Absence of a Diurnal Rhythm with Amenorrhea

1997 • 93 citations

Role of Gonadal Steroids in the Sexual Dimorphisms in Body Composition and Circulating Concentrations of Leptin

1999 • 93 citations

Regulation of lipid metabolism by cytokines during host defense

1996 • 92 citations

Leptin and diabetes in lipoatrophic mice

2000 • 89 citations

Leptin, Nutrition, and Reproduction: Timing Is Everything

2000 • 85 citations

Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass.

1994 • 84 citations

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

1997 • 74 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia

1999 • 73 citations

An in vivo study of the cortisol–cortisone shuttle in subcutaneous abdominal adipose tissue

1999 • 66 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II

1994 • 52 citations

Relationships and independence of body composition, sex hormones, fat distribution and other cardiovascular risk factors in overweight postmenopausal women.

1993 • 52 citations

Trandolapril Does Not Improve Insulin Sensitivity in Patients with Hypertension and Type 2 Diabetes: A Double-Blind, Placebo-Controlled Crossover Trial¹

2000 • 36 citations

Steroid hormone interconversions in human adipose tissue in vivo

1992 • 35 citations

Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein

2000 • 31 citations

Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting

2001 • 27 citations

Adipsin: Regulation and Dysregulation in Obesity and Other Metabolic States

1989 • 22 citations

The role of TNFa in adipocyte metabolism

1999 • 22 citations

Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase.

1998 • 7 citations