Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

1955 • 791 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Comparison of the bligh and dyer and folch methods for total lipid determination in a broad range of marine tissue

2001 • 684 citations

Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins

1997 • 658 citations

Mechanisms of nutritional and hormonal regulation of lipogenesis

2001 • 651 citations

Insulin signaling pathways in time and space

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Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

The plasma membrane

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Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

2002 • 557 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 515 citations

Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

1995 • 362 citations

Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control

2001 • 339 citations

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

2002 • 318 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

1999 • 251 citations

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane

1999 • 205 citations

Caveolin-deficient mice: insights into caveolar function human disease

2001 • 202 citations

Caveolin-deficient mice: insights into caveolar function human disease

2001 • 193 citations

Caveolin-1 Interacts with the Insulin Receptor and Can Differentially Modulate Insulin Signaling in Transfected Cos-7 Cells and Rat Adipose Cells

1999 • 188 citations

Regulation of cAMP-mediated Signal Transduction via Interaction of Caveolins with the Catalytic Subunit of Protein Kinase A

1999 • 178 citations

Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation

2002 • 166 citations

Essential Role of Caveolae in Interleukin-6- and Insulin-like Growth Factor I-triggered Akt-1-mediated Survival of Multiple Myeloma Cells

2003 • 148 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

GLUT4Gene Regulation and Manipulation

1999 • 133 citations

Lipid rafts and insulin signaling

2002 • 133 citations

Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase*

1998 • 125 citations

Subcellular Compartmentalization and Trafficking of the Insulin-Responsive Glucose Transporter, GLUT4

2001 • 119 citations

The Adipocyte Plasma Membrane Caveolin Functional/Structural Organization Is Necessary for the Efficient Endocytosis of GLUT4

2003 • 119 citations

Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles : a clue for increased fat depot and insulin resistance

1990 • 109 citations

Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A

2002 • 101 citations

Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome

1998 • 92 citations

Intracellular Retention of Glycosylphosphatidyl Inositol-Linked Proteins in Caveolin-Deficient Cells

2002 • 89 citations

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

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Lipotransin

1999 • 64 citations

A mutation (Trp1193?Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

1993 • 49 citations

Functional Properties of a Naturally Occurring Trp¹²⁰⁰→ Ser¹²⁰⁰Mutation of the Insulin Receptor

1990 • 48 citations

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.

1994 • 40 citations

Hsp70 Family Molecular Chaperones and Mutant Insulin Receptor: Differential Binding Specificities of BiP and Hsp70/Hsc70 Determines Accumulation or Degradation of Insulin Receptor

1996 • 34 citations

Insulin sensitizer YM268 ameliorates insulin resistance by normalizing the decreased content of GLUT4 in adipose tissue of obese Zucker rats

1997 • 21 citations

Intracellular retention of GPI-linked proteins in caveolin-deficient cells

2002 • 1 citations