MOLECULAR ANALYSIS OF V(D)J RECOMBINATION

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production

1986 • 331 citations

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

1991 • 288 citations

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

1987 • 278 citations

Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.

1992 • 246 citations

Increased Frequency of N-Region Insertion in a Murine Pre-B-Cell Line Infected with a Terminal Deoxynucleotidyl Transferase Retroviral Expression Vector

1987 • 214 citations

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1992 • 189 citations

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: Implications for the generation of antibody diversity

1990 • 183 citations

Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments

1989 • 159 citations

A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1989 • 157 citations

Site‐specific recombination in the immune system ¹

1991 • 156 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1992 • 146 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion

1991 • 128 citations

Detection of Somatic DNA Recombination in the Transgenic Mouse Brain

1991 • 121 citations

The Genetic, Molecular, and Cellular Basis of Antibody Formation: Some Facts and a Unifying Hypothesis

1967 • 119 citations

The mechanism of antigen receptor gene assembly

1989 • 108 citations

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

1992 • 92 citations

Cutting and closing without recombination in V(D)J joining.

1991 • 80 citations

Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P‐nucleotide additions in VJ‐coding joints

1991 • 72 citations

A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences

1987 • 58 citations

Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes

1984 • 50 citations

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.

1991 • 48 citations

Factors affecting the rearrangement efficiency of an Ig test gene.

1991 • 47 citations

Megabase inversions in the human genome as physiological events

1990 • 42 citations

NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization.

1989 • 34 citations

V gamma 3 T cell receptor rearrangement and expression in the adult thymus.

1991 • 31 citations

Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.

1991 • 20 citations

Terminal Transferase in Normal and Leukemic Cells

1986 • 19 citations

NMR-Distance Geometry Studies of Helical Errors and Sequence Dependent Conformations of DNA in Solution

1988 • 9 citations