A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

T Cell Anergy

2003 • 1,418 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

T cell fitness determined by signal strength

2003 • 478 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

IL-21 in Synergy with IL-15 or IL-18 Enhances IFN-γ Production in Human NK and T Cells

2003 • 376 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor.

1994 • 271 citations

Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

2001 • 237 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Further Checkpoints in Th1 Development

2002 • 206 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

1998 • 181 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

2000 • 143 citations

Uncoupling of Proliferative Potential and Gain of Effector Function by CD8+ T Cells Responding to Self-Antigens

2002 • 131 citations

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 • 127 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases

2002 • 120 citations

IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner

2000 • 118 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

2003 • 109 citations

Making and breaking tolerance

2002 • 107 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Bystander Activation Involving T Lymphocytes in Herpetic Stromal Keratitis

2001 • 95 citations

Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.

1994 • 95 citations

T Cell-Intrinsic Requirement for NF-κB Induction in Postdifferentiation IFN-γ Production and Clonal Expansion in a Th1 Response

2003 • 90 citations

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1993 • 87 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions

2000 • 81 citations

Defective T Cell Priming Associated with Aging Can Be Rescued by Signaling Through 4-1BB (CD137)

2002 • 57 citations

ABSENCE OF HOST B7 EXPRESSION IS SUFFICIENT FOR LONG-TERM MURINE VASCULARIZED HEART ALLOGRAFT SURVIVAL

2000 • 54 citations

Selection of Antigen-specific T Cells by a Single IEk Peptide Combination

1997 • 52 citations

The Balance Between Donor T Cell Anergy and Suppression Versus Lethal Graft-Versus-Host Disease Is Determined by Host Conditioning

2002 • 42 citations

Effector CD4 Cells Are Tolerized Upon Exposure to Parenchymal Self-Antigen

2002 • 35 citations

CD4 Cell Priming and Tolerization Are Differentially Programmed by APCs upon Initial Engagement

2002 • 34 citations

‘Bystander polarization’ of CD4⁺ T cells: activation with high‐dose IL‐2 renders naive T cells responsive to IL‐12 and/or IL‐18 in the absence of TCR ligation

2003 • 28 citations

Inflammatory Liver Steatosis Caused by IL-12 and IL-18

2003 • 27 citations

CD40 Ligation in the Presence of Self-Reactive CD8 T Cells Leads to Severe Immunopathology

2002 • 24 citations

Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-α and IFN-γ expression potentials

2003 • 16 citations