Structural aspects of serpin inhibition

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Natural protein proteinase inhibitors and their interaction with proteinases

1992 • 1,048 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Structure and Biological Role of Vitronectin

1991 • 477 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Hormone binding globulins undergo serpin conformational change in inflammation

1988 • 412 citations

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha1-proteinase inhibitor

1980 • 410 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures

1992 • 328 citations

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

1994 • 279 citations

Plakalbumin, α1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

1985 • 255 citations

Surface receptors for urokinase plasminogen activator

1988 • 222 citations

Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin

1991 • 217 citations

Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases.

1986 • 207 citations

Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and a large increase in conformational stability upon cleavage at their reactive sites.

1988 • 205 citations

Structural transition of α₁‐antitrypsin by a peptide sequentially similar to β‐strand s4A

1990 • 197 citations

Conformation of the reactive site loop of .alpha.1-proteinase inhibitor probed by limited proteolysis

1992 • 197 citations

RIBBON: a stereo cartoon drawing program for proteins

1988 • 190 citations

Zur Kenntnis der α-Globuline des menschlichen Normalserums

1955 • 181 citations

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1994 • 175 citations

Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins

1991 • 166 citations

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin

1990 • 164 citations

Substrate properties of C1 inhibitor Ma (alanine 434—-glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status

1991 • 147 citations

Ovalbumin and angiotensinogen lack serpin S–R conformational change

1989 • 136 citations

Ionic channels of excitable membranes. Second edition

1992 • 129 citations

Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.

1992 • 127 citations

Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.

1992 • 115 citations

Thrombin: Structure and Function

2012 • 115 citations

A comparison of three heparin-binding serine proteinase inhibitors.

1992 • 92 citations

Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor.

1993 • 92 citations

Conformational Variability of Chicken Cystatin

1993 • 79 citations

Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A

1992 • 77 citations

Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1·95Å resolution

1992 • 68 citations

Modeling the intact form of the α₁-proteinase inhibitor

1990 • 63 citations

Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT.

1993 • 63 citations

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A .beta.-sheet of the inhibitor during trapping of target proteinases

1993 • 62 citations

The S variant of human α₁-antitrypsin, structure and implications for function and metabolism

1989 • 59 citations

Heparin binding site, conformational change, and activation of antithrombin

1992 • 58 citations

Decreased affinity of recombinant antithrombin for heparin due to increased glycosylation

1992 • 55 citations

Type‐1 inhibitor of plasminogen activators

1991 • 54 citations

Structural comparisons of the native and reactive-centre-cleaved forms of α1-antitrypsin by neutron- and X-ray-scattering in solution

1990 • 50 citations

Inhibitory activity and conformational transition of α₁‐proteinase inhibitor variants

1991 • 49 citations

Conformational transition between native and reactive center cleaved forms of .alpha.1-antitrypsin by Fourier transform infrared spectroscopy and small-angle neutron scattering

1990 • 44 citations

Ueber die Enzyme

1894 • 41 citations

The α-helical content of calmodulin is increased by solution conditions favouring protein crystallisation

1992 • 40 citations

An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with α2-antiplasmin

1993 • 33 citations

Interaction of Human α₁-Proteinase Inhibitor with Chymotrypsinogen A and Crystallization of a Proteolytically Modified α₁-Proteinase Inhibitor

1982 • 29 citations

Proton NMR spectroscopic studies on the interactions between human plasma antithrombin III and defined low molecular weight heparin fragments

1992 • 14 citations

The N-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by, α-thrombin

1992 • 6 citations

[The nucleotide composition and oligonucleotides of the pyrimidyl-ribonuclease digest of valine-specific transfer RNA].

1965 • 3 citations