Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT.

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.

1982 • 427 citations

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

1978 • 264 citations

Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin

1991 • 217 citations

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes.

1990 • 190 citations

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

1992 • 184 citations

Alpha 1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase.

1988 • 170 citations

Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator

1989 • 157 citations

The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.

1988 • 139 citations

Endocytosis and degradation of alpha 1-antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor.

1990 • 121 citations

Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells.

1989 • 120 citations

Evidence for a tetrahedral intermediate complex during serpin-proteinase interactions

1991 • 113 citations

The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes

1991 • 106 citations

Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor.

1991 • 102 citations

Proteolytic inactivation of alpha-1-anti-chymotrypsin. Sites of cleavage and generation of chemotactic activity.

1991 • 92 citations

Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency.

1988 • 85 citations

Acute phase protein stimulation by alpha 1-antichymotrypsin-cathepsin G complexes. Evidence for the involvement of interleukin-6.

1990 • 68 citations

The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of alpha-1 antitrypsin-elastase complexes and amyloid-beta peptide.

1992 • 67 citations

The cellular basis for liver injury in α1-antitrypsin deficiency

1991 • 67 citations

Binding of vitronectin-thrombin-antithrombin III complex to human endothelial cells is mediated by the heparin binding site of vitronectin.

1992 • 63 citations

Binding of tissue-type plasminogen activator with human endothelial cell monolayers. Characterization of the high affinity interaction with plasminogen activator inhibitor-1.

1990 • 47 citations

Interaction of wild-type and catalytically inactive mutant forms of tissue-type plasminogen activator with human umbilical vein endothelial cell monolayers.

1990 • 42 citations

Identification of determinants involved in binding of tissue-type plasminogen activator-plasminogen activator inhibitor type 1 complexes to HepG2 cells.

1990 • 39 citations

IFNβ2/IL‐6 Is One of Several Cytokines That Modulate Acute Phase Gene Expression in Human Hepatocytes and Human Macrophages^a

1989 • 16 citations

Effect of Pseudomonas Elastase on Human Mononuclear Phagocyte α1-Antitrypsin Expression

1991 • 14 citations

Purification and characterization of a tissue plasminogen activator-inhibitor complex from human umbilical vein endothelial cell conditioned medium

1987 • 12 citations

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