Surface receptors for urokinase plasminogen activator

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Plasminogen activator inhibitors

1987 • 957 citations

A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells

1979 • 794 citations

Plasminogen activator inhibitors

1987 • 764 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES

1974 • 719 citations

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors

1987 • 625 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

The Peptide Chains of Human Plasmin

1967 • 478 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

1986 • 386 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.

1986 • 350 citations

A proenzyme form of human urokinase.

1982 • 350 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors

1987 • 327 citations

The binding of human plasminogen to fibrin and fibrinogen.

1983 • 321 citations

The Primary Structure of High Molecular Mass Urokinase from Human Urine. The Complete Amino Arid Sequence of the A Chain

1982 • 312 citations

Binding and activation of plasminogen on the platelet surface.

1985 • 312 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Structure and function of epidermal growth factor‐like regions in proteins

1988 • 305 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.

1988 • 275 citations

Isolation and characterization of urokinase from human plasma.

1982 • 274 citations

Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody

1982 • 269 citations

Characterization of human plasminogen II. Separation and partial characterization of different molecular forms of human plasminogen

1972 • 241 citations

One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.

1988 • 237 citations

cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.

1987 • 235 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

The human tissue plasminogen activator gene.

1986 • 230 citations

The Complete Amino Acid Sequence of Low Molecular Mass Urokinase from Human Urine

1982 • 230 citations

Autonomous functions of structural domains on human tissue-type plasminogen activator.

1986 • 226 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Binding of tissue plasminogen activator to cultured human endothelial cells.

1987 • 223 citations

The human urokinase-plasminogen activator gene and its promoter

1985 • 211 citations

Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing

1986 • 207 citations

Activation of plasminogen by pro-urokinase. I. Mechanism.

1986 • 206 citations

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.

1986 • 191 citations

The primary structure of high molecular mass urokinase from human urine

1982 • 191 citations

ACTIVATION OF PLASMINOGEN: A GENERAL MECHANISM FOR PRODUCING LOCALIZED EXTRACELLULAR PROTEOLYSIS

1978 • 176 citations

Plasminogen and tissue-type plasminogen activator bind to immobilized fibronectin.

1985 • 174 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Pro-urokinase: a study of its stability in plasma and of a mechanism for its selective fibrinolytic effect

1986 • 173 citations

The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.

1985 • 171 citations

Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator

1979 • 168 citations

Development and Function of Reproductive Organs

1983 • 167 citations

Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.

1984 • 166 citations

Receptor Mediated Binding of the Fibrinolytic Components, Plasminogen and Urokinase, to Peripheral Blood Cells

1987 • 165 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

Molecular Basis of Biological Degradative Processes

1978 • 163 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Association of fibronectin and vinculin with focal contacts and stress fibers in stationary hamster fibroblasts.

1982 • 138 citations

Synthesis of Human Plasminogen by the Liver

1980 • 137 citations

Activation of plasminogen by pro-urokinase. II. Kinetics.

1986 • 136 citations

Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.

1984 • 134 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

Isolation of a new specific plasminogen activator in hibitor from pregnancy plasma

1986 • 129 citations

Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface.

1987 • 125 citations

The Specific Mechanism of Activation of Human Plasminogen to Plasmin

1967 • 124 citations

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

1987 • 119 citations

Tissue-type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites.

1988 • 118 citations

An anticatalytic monoclonal antibody to avian plasminogen activator: Its effect on behavior of RSV-transformed chick fibroblasts

1986 • 114 citations

Laminin interacts with plasminogen and its tissue‐type activator

1984 • 112 citations

Fibrinolysis: An Overview

1984 • 111 citations

Primary structure of single-chain pro-urokinase.

1985 • 98 citations

An inhibitor of plasminogen activation from human placenta. Purification and characterization.

1987 • 96 citations

Plasminogen Is Present in the Basal Layer of the Epidermis

1983 • 91 citations

A synthetic approach to structure-function relationships in the murine epidermal growth factor molecule.

1986 • 91 citations

Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells.

1986 • 83 citations

Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase.

1982 • 78 citations

Binding of tissue plasminogen activator to human umbilical vein endothelial cells

1987 • 77 citations

Sensitive and specific enzyme-linked immunosorbent assay for urokinase-type plasminogen activator and its application to plasma from patients with breast cancer.

1988 • 73 citations

Receptor-Mediated Binding and Internalization of Toxins and Hormones

1981 • 73 citations

Chromosomal Locations of Human Tissue Plasminogen Activator and Urokinase Genes

1985 • 72 citations

The cellular target for the plasminogen activator, urokinase, in human fibroblasts - 66 000-dalton protein

1982 • 71 citations

Cryptic urokinase binding sites on human foreskin fibroblasts

1985 • 71 citations

Surface Characteristics of the U-937 Human Histiocytic Lymphoma Cell Line: Specific Changes During Inducible Morphologic and Functional Differentiation In Vitro

1981 • 68 citations

The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

1984 • 67 citations

Induction of antibody-dependent and nonspecific tumor killing in human monocytic leukemia cells by nonlymphocyte factors and phorbol ester

1982 • 65 citations

Human urokinase gene is located on the long arm of chromosome 10.

1985 • 63 citations

Plasminogen activators catalyse conversion of inhibitor from fibrosarcoma cells to an inactive form with a lower apparent molecular mass

1986 • 62 citations

The regulation of tissue plasminogen activator activity by human fibroblasts

1983 • 61 citations

In vitro degradation of radiolabelled, intact basement membrane mediated by cellular plasminogen activator

1982 • 60 citations

Molecular Biology of Human Plasminogen

1975 • 59 citations

Receptors for plasminogen activator, urokinase, in normal and Rous sarcoma virus-transformed mouse fibroblasts.

1985 • 54 citations

cDNA cloning and expression in E. coli of a plasminogen activator inhibitor (PAI) related to a PAI produced by Hep G2 hepatoma cell

1987 • 52 citations

Binding of urokinase to specific receptor sites on human breast cancer membranes

1987 • 52 citations

Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder.

1986 • 47 citations

Cleavage of bovine skin type III collagen by proteolytic enzymes. Relative resistance of the fibrillar form.

1985 • 47 citations

Differences in intracellular distribution of plasminogen activator in growing, confluent, and transformed 3T3 cells.

1979 • 45 citations

Mutant and chimeric recombinant plasminogen activators. Production in eukaryotic cells and preliminary characterization.

1987 • 37 citations

Importance, localization and functional properties of the cell-associated form of plasminogen activator in mouse peritoneal macrophages

1983 • 37 citations

The Mr 17 500 region of the A chain of urokinase is required for interaction with a specific receptor in A431 cells

1986 • 34 citations

Urokinase binding sites on human foreskin cells. Evidence for occupancy with endogenous urokinase

1985 • 33 citations

FIBRINOLYSIS | Overview

2006 • 28 citations

Evidence for membrane association of plasminogen activator activity in mouse macrophages

1980 • 26 citations

Cold-insoluble globulin, II[1,2]. Cyanogen bromide and plasminolysis fragments containing a label introduced by transamidation.

1977 • 26 citations

Assignment of the human tissue-type plasminogen activator gene (PLAT) to chromosome 8

1986 • 25 citations

Local synthesis of plasminogen by the seminiferous tubules of the testis

1986 • 24 citations

Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells

1980 • 22 citations

Interaction of urokinase with specific receptors abolishes the time of commitment to terminal differentiation of murine erythroleukaemia (Friend) cells

1987 • 17 citations

Interaction of urokinase with specific receptors abolishes the time of commitment to terminal differentiation of murine erythroleukaemia (Friend) cells

1987 • 15 citations

Tissue-type plasminogen activator gene is on chromosome 8

1986 • 14 citations

Human plasminogen activators. Genes and proteins structure.

1986 • 14 citations

Plasminogen activator is enriched in the synaptosomal plasma membranes

1982 • 13 citations

Plasminogen activator: Morphological evidence of binding, internalization and delivery to lysosomes in 3T3 mouse fibroblasts

1985 • 8 citations

Human genes and diseases

1987 • 3 citations

The binding and processing of plasminogen by Balb/c 3T3 and SV3T3 cells

1981 • 3 citations

Deleted Work

1955 • 0 citations