Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1983 • 651 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

Heparin : chemical and biological properties, clinical applications

1989 • 497 citations

Further characterization of the antithrombin-binding sequence in heparin

1982 • 450 citations

Purification of antithrombin III by affinity chromatography

1974 • 426 citations

Anticoagulant activity of heparin: Separation of high‐activity and low‐activity heparin species by affinity chromatography on immobilized antithrombin

1976 • 420 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

Determination of the operational molarity of solutions of bovine α-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration

1973 • 376 citations

²⁵²Cf‐Plasma Desorption Mass Spectrometry

1985 • 310 citations

The Size and Shape of Human and Bovine Antithrombin III

1977 • 264 citations

Thrombin structure and function

1991 • 250 citations

Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects.

1991 • 220 citations

Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and a large increase in conformational stability upon cleavage at their reactive sites.

1988 • 205 citations

Structural transition of α₁‐antitrypsin by a peptide sequentially similar to β‐strand s4A

1990 • 197 citations

Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin.

1982 • 180 citations

Cloning and expression of the cDNA for human antithrom, bin III

1982 • 179 citations

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin

1990 • 164 citations

Substrate properties of C1 inhibitor Ma (alanine 434—-glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status

1991 • 147 citations

Binding of high affinity heparin to antithrombin III. Characterization of the protein fluorescence enhancement.

1981 • 144 citations

The Binding of Low-Affinity and High-Affinity Heparin to Antithrombin. Fluorescence Studies

1978 • 136 citations

The active site of antithrombin. Release of the same proteolytically cleaved form of the inhibitor from complexes with factor IXa, factor Xa, and thrombin.

1982 • 134 citations

Heparin and ionic strength-dependent conversion of antithrombin III from an inhibitor to a substrate of alpha-thrombin.

1985 • 101 citations

Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasiliana and Tivela mactroides.

1987 • 99 citations

Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. Linkage of protease-inhibitor-heparin interactions in the reaction with thrombin.

1988 • 92 citations

Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity

1988 • 88 citations

Proposed heparin binding site in antithrombin based on arginine 47. A new variant Rouen-II, 47 Arg to Ser.

1988 • 82 citations

Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin.

1982 • 78 citations

Thermal denaturation of antithrombin III. Stabilization by heparin and lyotropic anions.

1981 • 75 citations

Decreased binding of heparin to antithrombin following the interaction between antithrombin and thrombin

1977 • 73 citations

The site in human antithrombin for functional proteolytic cleavage by human thrombin

1981 • 72 citations

Antithrombin III: structural and functional aspects

1990 • 70 citations

The production of an inactive form of antithrombin through limited proteolysis by thrombin

1979 • 66 citations

Modeling the intact form of the α₁-proteinase inhibitor

1990 • 63 citations

Properties of thrombin- and elastase-modified human antithrombin III

1988 • 61 citations

Molecular characterization of antithrombin III (ATIII) variants using polymerase chain reaction. Identification of the ATIII Charleville as an Ala 384 Pro mutation.

1989 • 57 citations

Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. The reaction step limiting heparin turnover in thrombin neutralization.

1986 • 55 citations

Antithrombin Cambridge II, 384 Ala to Ser Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins

1991 • 49 citations

Antithrombin Vicenza, Ala 384 to Pro (GCA to CCA) mutation, transforming the inhibitor into a substrate

1991 • 47 citations

A functional abnormal antithrombin III (AT III) deficiency : AT III Charleville

1985 • 23 citations

Hydrophobic residues 382-386 of antithrombin III, Ala-Ala-Ala-Ser-Thr, serve as the epitope for an antibody which facilitates hydrolysis of the inhibitor by thrombin.

1990 • 17 citations