An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with α2-antiplasmin

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Natural protein proteinase inhibitors and their interaction with proteinases

1992 • 1,048 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin

1967 • 848 citations

Proteolytic Enzymes: A Practical Approach

1990 • 413 citations

The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures

1992 • 328 citations

Mobile reactive centre of serpins and the control of thrombosis

1991 • 304 citations

Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin

1991 • 217 citations

Conformation of the reactive site loop of .alpha.1-proteinase inhibitor probed by limited proteolysis

1992 • 197 citations

On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin.

1979 • 187 citations

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

1991 • 178 citations

Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin).

1987 • 160 citations

Californium-252 plasma desorption time of flight mass spectroscopy of proteins

1984 • 148 citations

Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors

1989 • 138 citations

Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)

1991 • 135 citations

Affinity-chromatographic purification of human α2-antiplasmin

1980 • 132 citations

Evidence for a tetrahedral intermediate complex during serpin-proteinase interactions

1991 • 113 citations

Serpin-serine protease binding kinetics: .alpha.2-antiplasmin as a model inhibitor

1991 • 93 citations

Alpha-2-Antiplasmin: a Serpin with Two Separate But Overlapping Reactive Sites

1988 • 69 citations

Expression and Characterization of Pro α2-Plasmin Inhibitor

1989 • 62 citations

Serpins: structure and mechanism of action.

1990 • 22 citations