A comparison of three heparin-binding serine proteinase inhibitors.

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Further characterization of the antithrombin-binding sequence in heparin

1982 • 450 citations

Activation of heparin cofactor II by dermatan sulfate.

1983 • 439 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4

1984 • 344 citations

The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin.

1980 • 342 citations

Structure of a dermatan sulfate hexasaccharide that binds to heparin cofactor II with high affinity.

1990 • 298 citations

Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models.

1991 • 230 citations

Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction.

1981 • 222 citations

Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects.

1991 • 220 citations

The three-dimensional Structure of Bovine Platelet Factor 4 at 3.0-A Resolution

1989 • 187 citations

Kinetics of the heparin-enhanced antithrombin III/thrombin reaction. Evidence for a template model for the mechanism of action of heparin.

1982 • 172 citations

Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins

1991 • 166 citations

Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.

1987 • 161 citations

A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin.

1983 • 130 citations

The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans.

1991 • 123 citations

Hereditary Heparin Cofactor II Deficiency and the Risk of Development of Thrombosis

1987 • 102 citations

Heparin binding to protein C inhibitor.

1992 • 102 citations

Antithrombin: structure and function.

1991 • 100 citations

Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa

1989 • 97 citations

Heparin Cofactor IIOslo

1989 • 87 citations

Kinetics of reaction of human C-inhibitor with the human complement system proteases Cr and Cs

1980 • 85 citations

On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.

1990 • 78 citations

Role of thrombin exosites in inhibition by heparin cofactor II.

1992 • 72 citations

Role of lysine 173 in heparin binding to heparin cofactor II

1991 • 71 citations

Dependence of antithrombin III and thrombin binding stoichiometries and catalytic activity on the molecular weight of affinity-purified heparin.

1986 • 69 citations

Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.

1990 • 61 citations

Site-directed mutagenesis of arginine 103 and lysine 185 in the proposed glycosaminoglycan-binding site of heparin cofactor II.

1990 • 61 citations

Important role of arginine 129 in heparin-binding site of antithrombin III. Identification of a novel mutation arginine 129 to glutamine.

1990 • 55 citations

Protease specificity and heparin binding and activation of recombinant protease nexin I.

1991 • 54 citations

Effect of heparin on the glia-derived-nexin-thrombin interaction

1989 • 53 citations

Structural evidence for leucine at the reactive site of heparin cofactor II

1985 • 53 citations

Physicochemical Aspects of Heparin Cofactor IIa

1989 • 49 citations

Antithrombin conformation and the catalytic role of heparin. II. Is the heparin-induced conformational change in antithrombin required for rapid inactivation of thrombin?

1987 • 38 citations

Structural features of heparin and their effect on heparin cofactor II mediated inhibition of thrombin

1989 • 38 citations

Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin cofactor II

1988 • 37 citations

Evidence that arginine-129 and arginine-145 are located within the heparin binding site of human antithrombin III

1990 • 36 citations

Clinical aspects of antithrombin III deficiency.

1991 • 36 citations

Antithrombin III

1990 • 29 citations

Interaction of factor Xa with heparin does not contribute to the inhibition of factor Xa by antithrombin III-heparin

1990 • 22 citations

The heparin and pentosan polysulfate binding sites of human antithrombin overlap but are not identical

1989 • 14 citations