Prevention of Alzheimer's disease

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

2002 • 6,780 citations

Morbidity and mortality weekly report

1997 • 5,358 citations

Global prevalence of dementia: a Delphi consensus study

2005 • 5,214 citations

Fitness Effects on the Cognitive Function of Older Adults

2003 • 3,561 citations

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

2002 • 3,347 citations

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension

1991 • 2,850 citations

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

2005 • 2,476 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Alzheimer Disease in the US Population

2003 • 2,179 citations

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

2004 • 2,165 citations

Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment in Postmenopausal Women

2003 • 2,090 citations

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

2005 • 2,039 citations

An active and socially integrated lifestyle in late life might protect against dementia

2004 • 2,002 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Effects of Cognitive Training Interventions With Older Adults

2002 • 1,938 citations

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

1998 • 1,795 citations

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

2005 • 1,779 citations

Thiazolidinediones

2004 • 1,755 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

2001 • 1,567 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

1997 • 1,509 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults

2006 • 1,435 citations

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

1998 • 1,432 citations

Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial

1998 • 1,429 citations

The Study on Cognition and Prognosis in the Elderly (SCOPE)

2003 • 1,423 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

2001 • 1,382 citations

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1997 • 1,380 citations

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

2003 • 1,313 citations

Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

2005 • 1,294 citations

Conjugated Equine Estrogens and Incidence of Probable Dementia and Mild Cognitive Impairment in Postmenopausal Women<SUBTITLE>Women's Health Initiative Memory Study</SUBTITLE>

2004 • 1,287 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging

2002 • 1,246 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease

2005 • 1,240 citations

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

2001 • 1,183 citations

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

2002 • 1,166 citations

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

2003 • 1,129 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Low-Fat Dietary Pattern and Risk of Cardiovascular Disease

2006 • 1,097 citations

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials

1998 • 1,090 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

2002 • 1,068 citations

Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

2004 • 1,046 citations

Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease

2005 • 1,043 citations

Mediterranean diet and risk for Alzheimer's disease

2006 • 1,035 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 • 984 citations

A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia

1997 • 973 citations

A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

1997 • 965 citations

Effects of Blood Pressure Lowering With Perindopril and Indapamide Therapy on Dementia and Cognitive Decline in Patients With Cerebrovascular Disease

2003 • 963 citations

Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression

2003 • 955 citations

The Prevention of Dementia With Antihypertensive Treatment<subtitle>New Evidence From the Systolic Hypertension in Europe (Syst-Eur) Study</subtitle>

2002 • 879 citations

Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women<SUBTITLE>The Cache County Study</SUBTITLE>

2002 • 877 citations

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

2005 • 859 citations

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population

1995 • 814 citations

Cognitive Reserve and Alzheimer Disease

2006 • 806 citations

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements

2004 • 725 citations

The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease

1998 • 722 citations

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

2002 • 680 citations

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

2006 • 674 citations

Hyperinsulinemia and risk of Alzheimer disease

2004 • 666 citations

Physical Activity, APOE Genotype, and Dementia Risk: Findings from the Cardiovascular Health Cognition Study

2005 • 661 citations

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease

2006 • 647 citations

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

1997 • 612 citations

Intake of flavonoids and risk of dementia.

2000 • 611 citations

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

2003 • 609 citations

Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone: A Preliminary Study

2005 • 584 citations

The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease

1998 • 579 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

2005 • 543 citations

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.

1997 • 521 citations

Use of Lipid-Lowering Agents, Indication Bias, and the Risk of Dementia in Community-Dwelling Elderly People

2002 • 519 citations

Is MCI really just early dementia? A systematic review of conversion studies

2004 • 518 citations

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

2003 • 510 citations

Association Between Nutritional Status and Cognitive Functioning in a Healthy Elderly Population

1983 • 480 citations

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

2005 • 455 citations

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

1999 • 446 citations

Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine1

2006 • 445 citations

Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study

1999 • 443 citations

Dietary factors and Alzheimer's disease

2004 • 430 citations

Use of ramipril in preventing stroke: double blind randomised trial

2002 • 421 citations

Antioxidant Vitamin Intake and Risk of Alzheimer Disease

2003 • 416 citations

Epidemiology of Dementia and Alzheimer's Disease

1998 • 410 citations

Total serum homocysteine in senile dementia of Alzheimer type

1998 • 410 citations

Low-Fat Dietary Pattern and Risk of Colorectal Cancer

2006 • 399 citations

Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review

2004 • 395 citations

A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease

1999 • 393 citations

Rofecoxib

2004 • 390 citations

A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment

2005 • 386 citations

Relation of Plasma Lipids to Alzheimer Disease and Vascular Dementia

2004 • 386 citations

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

2004 • 384 citations

Cognitive Reserve and Alzheimer Disease

2006 • 383 citations

Benefits of fatty fish on dementia risk are stronger for those without APOE ε4

2005 • 378 citations

Free testosterone and risk for Alzheimer disease in older men

2004 • 373 citations

Antihypertensive Medication Use and Incident Alzheimer Disease

2006 • 345 citations

Ginkgo biloba for cerebral insufficiency.

1992 • 342 citations

The Relation Between Antioxidants and Memory Performance in the Old and Very Old

1997 • 341 citations

Resveratrol—A boon for treating Alzheimer's disease?

2006 • 339 citations

Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation

2005 • 339 citations

Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment

1997 • 337 citations

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

1998 • 337 citations

Curry Consumption and Cognitive Function in the Elderly

2006 • 335 citations

Immunology and immunotherapy of Alzheimer's disease

2006 • 323 citations

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

2000 • 318 citations

Reduced incidence of AD with NSAID but not H ₂ receptor antagonists

2002 • 311 citations

Do Statins Reduce Risk of Incident Dementia and Alzheimer Disease?<subtitle>The Cache County Study</subtitle>

2005 • 304 citations

Update on hypertension and Alzheimer's disease

2006 • 292 citations

Effects of estrogen on cognition, mood, and cerebral blood flow in AD

2000 • 292 citations

Association of metabolic syndrome with Alzheimer disease

2006 • 290 citations

Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment

2005 • 279 citations

Statin Use and the Risk of Incident Dementia

2005 • 266 citations

High-dose estradiol improves cognition for women with AD

2001 • 262 citations

Homocysteine potentiates copper‐ and amyloid beta peptide‐mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's‐type neurodegenerative pathways

2001 • 258 citations

Dietary Antioxidants and Cognitive Function in a Population-based Sample of Older Persons: The Rotterdam Study

1996 • 254 citations

Antihypertensive drugs and incidence of dementia: the Rotterdam Study

2001 • 246 citations

Statin therapy and risk of dementia in the elderly

2004 • 243 citations

Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer’s disease: results of a placebo-controlled, double-blind, pilot study

1999 • 241 citations

Demonstrating the case that AD is a vascular disease: epidemiologic evidence

2002 • 229 citations

Occurrence and Progression of Dementia in a Community Population Aged 75 Years and Older

1999 • 217 citations

Hyperinsulinemia Provokes Synchronous Increases in Central Inflammation and β-Amyloid in Normal Adults

2005 • 213 citations

Effect of Raloxifene on Prevention of Dementia and Cognitive Impairment in Older Women: The Multiple Outcomes of Raloxifene Evaluation (MORE) Randomized Trial

2005 • 213 citations

Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimer's Disease

2000 • 209 citations

Mediterranean diet and cognitive decline

2004 • 203 citations

The Impact of the Use of Statins on the Prevalence of Dementia and the Progression of Cognitive Impairment

2002 • 189 citations

Randomized pilot study of nimesulide treatment in Alzheimer’s disease

2002 • 175 citations

A Randomized, Double-Blind, Placebo-Controlled Trial of Two Doses of Ginkgo Biloba Extract in Dementia of the Alzheimers Type

2005 • 171 citations

The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia

2006 • 170 citations

Neuroprotective Effects of Huperzine A

2005 • 158 citations

Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging

2005 • 152 citations

Cohort Study of Vitamin C Intake and Cognitive Impairment

1998 • 140 citations

Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo

1998 • 120 citations

Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease1

2006 • 119 citations

γ-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

2002 • 118 citations

Obesity, Abdominal Obesity and Alzheimer Disease

2006 • 113 citations

Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E

2005 • 108 citations

Effect of Pharmacologic Lipid Lowering on Health‐Related Quality of Life in Older Persons: Results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study

1997 • 103 citations

Statin therapy in Alzheimer's disease

2006 • 103 citations

Links Between the Pathology of Alzheimer's Disease and Vascular Dementia

2004 • 101 citations

DHEA treatment of Alzheimer’s disease

2003 • 99 citations

Folates and prevention of disease

2001 • 98 citations

Use of Lipid‐Lowering Drugs in Older Adults With and Without Dementia: A Community‐Based Epidemiological Study

2002 • 95 citations

Use of Antioxidant Supplements and Its Association with Cognitive Function in a Rural Elderly Cohort: The MoVIES Project

1998 • 91 citations

Systemic Oxidative Stress and Cognitive Performance in the Population-Based EVA Study

1998 • 79 citations

Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study

2005 • 75 citations

Double placebo design in a prevention trial for Alzheimer's disease

2002 • 71 citations

Arundic Acid Ameliorates Cerebral Amyloidosis and Gliosis in Alzheimer Transgenic Mice

2006 • 66 citations

Aspirin, NSAIDs, Risk of Dementia, and Influence of the Apolipoprotein E Epsilon 4 Allele in an Elderly Population

2004 • 64 citations

A longitudinal study of factors predicting change in cognitive test scores over time, in an older hypertensive population

1996 • 62 citations

The GuidAge study

2006 • 62 citations

Prevention of Alzheimer Disease

2006 • 57 citations

Increasing Testosterone Levels and Effects on Cognitive Functions in Elderly Men and Women: A Review

2005 • 56 citations

Risk of Mortality with Vitamin E Supplements: The Cache County Study

2007 • 54 citations

Apolipoprotein E Genotypes and the Incidence of Alzheimer's Disease among Persons Aged 75 Years and Older: Variation by Use of Antihypertensive Medication?

2001 • 51 citations

NSAIDs for the Chemoprevention of Alzheimer’s Disease

2007 • 51 citations

Analysis of plasma tocopherols α, γ, and 5-nitro-γ in rats with inflammation by HPLC coulometric detection

2002 • 47 citations

Ginkgo biloba: A Cognitive Enhancer?

2002 • 45 citations

HRT and dementia.

1999 • 38 citations

[O2‐01‐05]: A placebo‐controlled, double‐blind trial of the selective AB‐42 lowering agent, flurizan (MPC‐7869, (R)‐flurbiprofen) in patients with mild to moderate Alzheimer's disease

2005 • 11 citations

Diet and the risk for Alzheimer's disease

2006 • 11 citations

Deleted Work

1955 • 0 citations