Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

A simple, rapid method for the purification of poly A+ RNA.

1988 • 382 citations

The gene family encoding the mouse ribosomal protein L32 contains a uniquely expressed intron-containing gene and an unmutated processed gene

1984 • 381 citations

Cytokine Actions in the Central Nervous System

1998 • 373 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

1993 • 357 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

1988 • 228 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.

1997 • 211 citations

Stat4 Is Expressed in Activated Peripheral Blood Monocytes, Dendritic Cells, and Macrophages at Sites of Th1-Mediated Inflammation

2000 • 191 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

Inflammatory cytokines in the brain: Does the CNS shape immune responses?

1994 • 180 citations

The effects of interferon-γ on the central nervous system

1997 • 157 citations

Involvement of STAT-1 and Ets Family Members in Interferon-γ Induction of CD40 Transcription in Microglia/Macrophages

2000 • 157 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ

2000 • 144 citations

The SOCS proteins: a new family of negative regulators of signal transduction

1998 • 135 citations

Differential Regulation and Function of Fas Expression on Glial Cells

2000 • 132 citations

Cytokines and STAT Signaling

1999 • 128 citations

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.

1997 • 112 citations

Members of the JAK/STAT proteins are expressed and regulated during development in the mammalian forebrain

1998 • 112 citations

Signalling through the JAK–STAT pathway in the developing brain

1999 • 111 citations

Activation of the Transcription Factor ISGF3 by Interferon-gamma

1999 • 110 citations

Regulation of T helper cell differentiation by STAT molecules

1998 • 107 citations

C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System

1999 • 107 citations

Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro.

1996 • 100 citations

Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

1996 • 96 citations

Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis

2000 • 96 citations

IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes.

1999 • 91 citations

IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element.

1998 • 91 citations

T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases

1999 • 81 citations

Cellular Responses to Interferons and Other Cytokines: The JAK–STAT Paradigm

1998 • 81 citations

Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.

1996 • 76 citations

IFN-γ Regulation of the Type IV Class II Transactivator Promoter in Astrocytes

1999 • 72 citations

The immune response in viral encephalitis.

1992 • 71 citations

IFN-γ Induction of the Human Monocyte Chemoattractant Protein (hMCP)-1 Gene in Astrocytoma Cells: Functional Interaction Between an IFN-γ-Activated Site and a GC-Rich Element

1998 • 69 citations

Expression of ?suppressor of cytokine signalling? (SOCS) genes in the developing and adult mouse nervous system

2000 • 67 citations

STAT3 and NFκB Activation Precedes Glial Reactivity in the Excitotoxically Injured Young Cortex but not in the Corresponding Distal Thalamic Nuclei

2000 • 67 citations

Interferon γ-induced transcription of the murine ISGF3γ (p48) gene is mediated by novel factors

1997 • 60 citations

Interleukin-12 and interferon-gamma. Do they always go together?

1995 • 55 citations

The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling.

1999 • 40 citations

STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats

2001 • 39 citations

Transcriptional regulation of the intercellular adhesion molecule-1 gene by proinflammatory cytokines in human astrocytes

1999 • 38 citations

Expression of the Transcription Factor STAT-1α in Insulinoma Cells Protects against Cytotoxic Effects of Multiple Cytokines

2001 • 33 citations

Analysis of Gene Expression by Multiprobe RNase Protection Assay

2003 • 28 citations

Protein–DNA Interactions in Interferon-γ Signaling

1998 • 22 citations

Tumor Necrosis Factor-alpha Signals to the IFN-gamma Receptor Complex to Increase Stat1alpha Activation

1999 • 20 citations

Neurodegeneration Methods and Protocols

1998 • 14 citations

Deleted Work

1955 • 0 citations