IFN-γ Regulation of the Type IV Class II Transactivator Promoter in Astrocytes

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

1998 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.

1996 • 230 citations

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1997 • 177 citations

Convergence of TNF and IFN signalling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/ B promoter element

1997 • 165 citations

IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.

1997 • 162 citations

IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.

1997 • 153 citations

Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study

1990 • 145 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Cytokines: Influence on Glial Cell Gene Expression and Function

1997 • 145 citations

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5

1997 • 140 citations

Regulation of MHC class I and II gene transcription: differences and similarities

1998 • 139 citations

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

1997 • 129 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein

1997 • 118 citations

Tumor necrosis factor-α enhances interferon-γ-mediated class II antigen expression on astrocytes

1989 • 118 citations

Quantitative control of MHC class II expression by the transactivator CIITA

1998 • 117 citations

Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat

1985 • 115 citations

Human astrocytes are only partially competent antigen presenting cells

1994 • 106 citations

Immune Responses in MHC Class II-Deficient MICE

1995 • 101 citations

Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-γ-Activated SJL/J Astrocytes

1998 • 91 citations

Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α

1990 • 91 citations

HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells. Involvement of Janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways.

1996 • 90 citations

Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death

1996 • 89 citations

CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promotersin vivo

1998 • 72 citations

Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta.

1996 • 63 citations

Regulation of Class II MHC Expression

1996 • 63 citations

Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF–κB and C/EBP isoforms

1998 • 59 citations

IL-1β Inhibits IFN-γ-Induced Class II MHC Expression by Suppressing Transcription of the Class II Transactivator Gene

1999 • 33 citations

Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-alpha-mediated class II MHC gene expression.

1994 • 30 citations

THE INDUCTION OF CLASS I AND II MAJOR HISTOCOMPATIBILITY COMPLEX BY ALLOGENEIC STIMULATION IS DEPENDENT ON THE TRANSCRIPTION FACTOR INTERFERON REGULATORY FACTOR 1 (IRF-1)

1996 • 29 citations

Tumor necrosis factor alpha response elements in the HLA-DRA promoter: identification of a tumor necrosis factor alpha-induced DNA-protein complex in astrocytes.

1992 • 26 citations