Expansion, Selection and Mutation of Antigen‐Specific B Cells in Germinal Centers

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Fundamental Immunology

1990 • 607 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Idiotypic Networks and Other Preconceived Ideas

1984 • 543 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

ANTIGENS IN IMMUNITY

1968 • 497 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

B–cell memory is short-lived in the absence of antigen

1988 • 430 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 418 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

1980 • 377 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

The B-cell antigen receptor of the five immunoglobulin classes

1991 • 302 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

1983 • 274 citations

Kinetic maturation of an immune response

1991 • 274 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Recombinant 25‐kDa CD23 and interleukin 1α promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis

1991 • 264 citations

The generation of memory cells. I. The role of C3 in the generation of B memory cells.

1977 • 235 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

1987 • 230 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

1989 • 215 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

Complement Dependence of Localisation of Aggregated IgG in Germinal Centres

1975 • 210 citations

Population Dynamics of Bone Marrow B Lymphocytes

1986 • 210 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Selection of a Single Antibody-Forming Cell Clone and Its Propagation in Syngeneic Mice

1970 • 175 citations

THE IMMUNOGLOBULINS OF MICE

1965 • 169 citations

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1988 • 135 citations

Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse.

1978 • 116 citations

The localization of non-microbial antigens in the draining lymph nodes of tolerant, normal and primed rabbits.

1967 • 104 citations

Induction of resting B cells to DNA synthesis by soluble monoclonal anti‐immunoglobulin

1984 • 103 citations

Somatic hypermutation in V-regions.

1991 • 75 citations

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells.

1989 • 64 citations

Population kinetics of rat peripheral B cells.

1988 • 60 citations

Somatic mutation in constant regions of mouse lambda 1 light chains.

1991 • 55 citations

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

1990 • 54 citations

Normal serum immunoglobulins influence the numbers of bone marrow pre‐B and B cells

1991 • 49 citations

Mechanisms in B-cell neoplasia

1984 • 41 citations

T helper cell epitope of rabies virus nucleoprotein defined by tri‐ and tetrapeptides

1991 • 40 citations

Clonal Selection in B‐Cell Growth and Differentiation

1987 • 34 citations

The Generation of B-Cell Memory: A Working Hypothesis

1990 • 25 citations

Mechanisms in B-Cell Neoplasia 1988

1988 • 15 citations

Prolonged growth of activated B lymphocytes requires interaction with helper T cells

1987 • 10 citations

Regulation of Growth and Differentiating of Pre‐Activated B Lymphocytes

1988 • 5 citations