Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion

1976 • 1,926 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

DISQUISITIONS ON ORIGINAL ANTIGENIC SIN

1966 • 568 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

Polyadenylic Acid Sequences in the Heterogeneous Nuclear RNA and Rapidly-Labeled Polyribosomal RNA of HeLa Cells: Possible Evidence for a Precursor Relationship

1971 • 503 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

Circulating T and B lymphocytes of the mouse

1973 • 417 citations

The clonal selection theory of acquired immunity

1960 • 396 citations

EPIDEMIOLOGIC AND IMMUNOLOGIC SIGNIFICANCE OF AGE DISTRIBUTION OF ANTIBODY TO ANTIGENIC VARIANTS OF INFLUENZA VIRUS

1953 • 390 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

INFLUENZA: THE NEWE ACQUAYANTANCE

1953 • 183 citations

Selection of a Single Antibody-Forming Cell Clone and Its Propagation in Syngeneic Mice

1970 • 175 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes

1984 • 157 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

1985 • 150 citations

Somatic variants of murine immunoglobulin λ light chains

1982 • 136 citations

Localization of murine Ig-1b and Ig-1a (IgG 2a) allotypic determinants detected with monoclonal antibodies

1979 • 134 citations

A new classification of mouse VH sequences

1984 • 119 citations

Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies.

1984 • 116 citations

Strain differences in the fine specificity of mouse antihapten antibodies

1973 • 116 citations

Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue.

1966 • 109 citations

Demonstration that IgG memory is carried by IgG‐bearing cells

1976 • 108 citations

Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.

1985 • 99 citations

T lymphocyte tissue culture lines produced by cell hybridization

1977 • 98 citations

Somatic diversification of immunoglobulins.

1984 • 94 citations

Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells.

1984 • 88 citations

Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.

1982 • 86 citations

Monoclonal antibodies and T-cell hybridomas : perspectives and technical advances

1981 • 76 citations

Switch in Immunoglobulin Class Production Observed in Single Clones of Committed Lymphocytes

1978 • 68 citations

The immune response against anti‐idiotope antibodies. I. Induction of idiotope‐bearing antibodies and analysis of the idiotope repertoire

1982 • 67 citations

Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodies.

1985 • 63 citations

Factors affecting the propagation of a B Cell Clone forming antibody to the 2,4‐dinitrophenyl group

1972 • 56 citations

Molecular basis of an isogeneic anti-idiotypic response.

1984 • 51 citations

Restricted association of V and J-C gene segments for mouse lambda chains.

1984 • 45 citations

Specificity, duration and mechanism of idiotype suppression induced by neonatal injection of monoclonal anti‐idiotope antibodies into mice

1984 • 44 citations

Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.

1986 • 43 citations

Sequence analysis of non-expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells.

1985 • 22 citations

A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes.

1984 • 21 citations

An unusual type of V–J joining diversifies the primary repertoire of mouse λ1 light chains

1985 • 17 citations