An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria

Lactic Dehydrogenase Activity in Blood.

1955 • 2,433 citations

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization

1992 • 597 citations

Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

1997 • 508 citations

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

1997 • 477 citations

Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

1996 • 435 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

1997 • 328 citations

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1997 • 316 citations

Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli

1991 • 309 citations

Mammalian Mitochondria Possess Homologous DNA Recombination Activity

1996 • 275 citations

Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

1992 • 269 citations

Unified catalytic mechanism for DNA glycosylases

1994 • 266 citations

Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage

1997 • 258 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

Escherichia coli endonuclease III is not an endonuclease but a β-elimination catalyst

1987 • 247 citations

Reconstitution of the DNA base excision—repair pathway

1994 • 243 citations

Implication of Mammalian Ribosomal Protein S3 in the Processing of DNA Damage

1995 • 193 citations

Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria

1995 • 191 citations

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells.

1993 • 189 citations

Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

1993 • 175 citations

Mechanism of action of Escherichia coli endonuclease III

1987 • 162 citations

A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2

1980 • 162 citations

Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells.

1988 • 152 citations

Studies on the Catalytic Mechanism of Five DNA Glycosylases

1995 • 142 citations

The Catalytic Mechanism of Fpg Protein

1995 • 124 citations

The mechanisms of action ofE.coliendonuclease III and T4 UV endonuclease (endonuclease V) at AP sites

1988 • 121 citations

A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities.

1996 • 120 citations

3‘- and 5‘-Strand Cleavage Reactions Catalyzed by the Fpg Protein from Escherichia coli Occur via Successive β- and δ-Elimination Mechanisms, Respectively

1996 • 114 citations

The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells.

1980 • 109 citations

Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat

1988 • 98 citations

Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA

1992 • 84 citations

Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA

1990 • 79 citations

Purification and properties of mitochondrial uracil-DNA glycosylase from rat liver

1988 • 73 citations

Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells

1996 • 71 citations

Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo.

1988 • 70 citations

Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria

1995 • 51 citations

Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells

1993 • 47 citations

Methyl methanesulfonate adduct formation and repair in the DHFR gene and in mitochondrial DNA in hamster cells

1993 • 34 citations

Use of Percoll Gradients for Isolation of Human Placenta Mitochondria Suitable for Investigating Outer Membrane Proteins

1993 • 33 citations

Formamidopyrimidine DNA glycosylase in the yeastSaccharomyces cerevisiae

1994 • 32 citations

Levels of the Mitochondrial Endonuclease during Rat Cardiac Development Implicate a Role for the Enzyme in Repair of Oxidative Damage in Mitochondrial DNA

1994 • 20 citations