Age-Related Mitochondrial DNA Deletions

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

Aging and oxidative stress: Modulation by dietary restriction

1996 • 450 citations

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

1992 • 354 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Marked Changes in Mitochondrial DNA Deletion Levels in Alzheimer Brains

1994 • 307 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

1996 • 251 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

1992 • 196 citations

Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction

1992 • 190 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Lipid peroxidation in mitochondria

1988 • 185 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Protection of DNA damage by dietary restriction

1992 • 161 citations

Anti-lipoperoxidation action of food restriction

1987 • 139 citations

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1995 • 123 citations

Correlation Between Mitochondrial DNA 4977-bp Deletion and Respiratory Chain Enzyme Activities in Aging Human Skeletal Muscles

1994 • 115 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1995 • 109 citations

Quantitation of a mitochondrial DNA deletion in Parkinson's disease

1992 • 87 citations

Deleted mitochondrial DNA in the skeletal muscle of aged individuals.

1991 • 79 citations

Dietary modulation of DNA damage in human

1991 • 78 citations

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

1994 • 69 citations

Sensitivity of mitochondrial transcription to different free radical species

1994 • 69 citations

Caloric Restriction: Conservation of in Vivo Cellular Replicative Capacity Accompanies Life-Span Extension in Mice

1995 • 61 citations

Mitochondrial DNA Mutations in Epilepsy and Neurological Disease

1994 • 57 citations

Quantification of oxidative DNA modifications in mitochondria

1993 • 51 citations

Aging-associated Deletions of Human Diaphragmatic Mitochondrial DNA

1992 • 50 citations

Oxidative stress and aging

1996 • 45 citations

Influence of Diet on Fatal Neoplastic Disease in Male Fischer 344 Rats

1991 • 45 citations

Antioxidants reduce peroxyl-mediated inhibition of mitochondrial transcription

1994 • 43 citations

Biological effects of dietary restriction

1991 • 43 citations

Mitochondrial DNA deletions in dilated cardiomyopathy: A clinical study employing endomyocardial sampling

1994 • 39 citations

Detoxification of reactive aldehydes in mitochondria: Effects of age and dietary restriction

1996 • 38 citations

Complex forms and replicative intermediates of mitochondrial DNA in tissues from adult and senescent mice

1977 • 33 citations

Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys

1994 • 33 citations

Mitochondrial Aging and Lipoperoxidative Productsa

1996 • 28 citations

Structural and replicative forms of mitochondrial DNA in tissues from adult and senescent BALB/c mice and Fischer 344 rats

1984 • 25 citations

Effects of Caloric Restriction on Aflatoxin B1 Metabolism and DNA Modification in Fischer 344 Rats

1991 • 16 citations

Tissue-specific susceptibility to peroxyl radical-mediated inhibition of mitochondrial transcription

1994 • 15 citations

Modulation of oxidative stress as a means of life-prolonging action of dietary restriction

1995 • 12 citations