From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1996 • 2,325 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

2005 • 922 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Nicotinic acetylcholine involvement in cognitive function in animals

1998 • 689 citations

Molecular and Cellular Aspects of Nicotine Abuse

1996 • 605 citations

Nicotinic acetylcholine receptors and the regulation of neuronal signalling

2004 • 584 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

2005 • 534 citations

International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.

1999 • 522 citations

Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation

2005 • 478 citations

Effect of nicotine and nicotinic receptors on anxiety and depression

2002 • 454 citations

Desensitization of neuronal nicotinic receptors

2002 • 447 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:In VitroandIn VivoCharacterization

2005 • 433 citations

Effects of nicotinic stimulation on cognitive performance

2003 • 401 citations

Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.

1997 • 387 citations

Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology

1995 • 385 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

1998 • 365 citations

Ca2+ permeability of nicotinic acetylcholine receptors

2003 • 311 citations

Smoking, nicotine and Parkinson's disease

2004 • 309 citations

Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine

2002 • 297 citations

Structure and Activity of Acetylcholine

1970 • 273 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

[3H]cytisine binding to nicotinic cholinergic receptors in brain.

1991 • 258 citations

Effects of Nicotine on Cognitive Deficits in Schizophrenia

2004 • 239 citations

Smoking and Parkinson’s and Alzheimer’s disease: review of the epidemiological studies

2000 • 235 citations

The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

2004 • 223 citations

Unconventional ligands and modulators of nicotinic receptors

2002 • 204 citations

Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism

2005 • 187 citations

Epibatidine is a nicotinic analgesic

1993 • 168 citations

UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes

2000 • 165 citations

Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline

1990 • 140 citations

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In Vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand

1996 • 136 citations

Attentional effects of nicotinic agonists in rats

2003 • 133 citations

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single‐channel behaviour.

1997 • 126 citations

Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics

2000 • 126 citations

Transdermal nicotine for induction of remission in ulcerative colitis

2004 • 122 citations

Neuroprotection by Nicotine in Mouse Primary Cortical Cultures Involves Activation of Calcineurin and L-Type Calcium Channel Inactivation

2003 • 121 citations

Characterization of Human α4β2-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed in Native Nicotinic Receptor-Null SH-EP1 Human Epithelial Cells

2003 • 119 citations

Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor

2004 • 117 citations

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine.

2002 • 116 citations

SSR591813, a Novel Selective and Partial α₄β₂ Nicotinic Receptor Agonist with Potential as an Aid to Smoking Cessation

2003 • 116 citations

Transdermal Nicotine and Haloperidol in Tourette's Disorder

2001 • 115 citations

Synthesis of Analogues of (−)-Cytisine for in Vivo Studies of Nicotinic Receptors Using Positron Emission Tomography

2000 • 110 citations

Comparative structure of human neuronal α2–α7 and β2–β4 nicotinic acetylcholine receptor subunits and functional expression of the α2, α3, α4, α7, β2, and β4 subunits

1996 • 99 citations

Some studies on cytisine and its methylated derivatives

1969 • 99 citations

Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells

2005 • 95 citations

Pharmacological effects of epibatidine optical enantiomers

1994 • 94 citations

Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson's disease

2003 • 94 citations

The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Is Transduced into Cellular Responses in Neurons: Ca²⁺Signals and Neurotransmitter Release.

2003 • 92 citations

The Structures of Neuronal Nicotinic Receptors

2000 • 91 citations

Exploring the Nature of Molecular Recognition in Nicotinic Acetylcholine Receptors

2000 • 90 citations

Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes

2003 • 89 citations

Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands

2001 • 87 citations

Nicotinic receptors regulate B lymphocyte activation and immune response

2005 • 80 citations

Neuronal nicotinic receptor inhibition for treating mood disorders preliminary controlled evidence with mecamylamine

2002 • 74 citations

Asymmetric Structural Motions of the Homomeric α7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular Dynamics Simulation

2003 • 73 citations

Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells

2000 • 72 citations

Loss of α‐conotoxinMII‐ and A85380‐sensitive nicotinic receptors in Parkinson's disease striatum

2004 • 65 citations

Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release

2004 • 64 citations

Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors

2001 • 63 citations

Epibatidine structure–activity relationships

2004 • 62 citations

A structural model of agonist binding to the α3β4 neuronal nicotinic receptor

2003 • 54 citations

Modulation of working, short- and long-term memory by nicotinic receptors in the basolateral amygdala in rats

2004 • 49 citations

Coupling of human nicotinic acetylcholine receptors α7 to calcium channels in GH3 cells

2004 • 49 citations

Discovery of the α7 Nicotinic Acetylcholine Receptor Agonists. (R)-3‘-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5‘-[1‘,3‘]oxazolidin-2‘-one as a Novel, Potent, Selective, and Orally Bioavailable Ligand

2005 • 46 citations

Stimulation of nicotinic acetylcholine receptors protects motor neurons

2005 • 46 citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2‘-Fluoro-3‘-(substituted phenyl)deschloroepibatidine Analogues. Novel Nicotinic Antagonist

2004 • 43 citations

Heterologous Expression of Human α6β4β3α5 Nicotinic Acetylcholine Receptors: Binding Properties Consistent with Their Natural Expression Require Quaternary Subunit Assembly Including the α5 Subunit

2004 • 42 citations

Recent Developments in the Synthesis of Nicotinic Acetylcholine Receptor Ligands

2004 • 39 citations

Novel Pyridyl Ring C5 Substituted Analogues of Epibatidine and 3-(1-Methyl-2(S)- pyrrolidinylmethoxy)pyridine (A-84543) as Highly Selective Agents for Neuronal Nicotinic Acetylcholine Receptors Containing β2 Subunits

2004 • 37 citations

Changes in compulsion and anxiety symptoms with nicotine transdermal patches in non-smoking obsessive-compulsive disorder patients.

2004 • 37 citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘-Substituted-3‘-phenyl-5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel Nicotinic Antagonist

2001 • 36 citations

Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors

2004 • 34 citations

RECENT SYNTHESES OF EPIBATIDINE. A REVIEW

2002 • 29 citations

Pharmacological similarities between native brain and heterologously expressed α4β2 nicotinic receptors

1999 • 28 citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 3‘-Substituted Deschloroepibatidine Analogues. Novel Nicotinic Antagonists

2005 • 26 citations

Nicotine enemas for treatment of ulcerative colitis: a study of the pharmacokinetics and adverse events associated with three doses of nicotine

2004 • 25 citations

THE PHYSIOLOGICAL ACTION OF CYTISINE, THE ACTIVE ALKALOID OF LABURNUM (CYTISUSLABURNUM)

1912 • 19 citations

Neuronal Nicotinic Acetylcholine Receptor Agonists: Pharmacophores, Evolutionary QSAR and 3D-QSAR models

2004 • 18 citations

Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds

2004 • 14 citations

Mecamylamine moderates cue-induced emotional responses in smokers

2004 • 13 citations

Correction to “Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells”: TABLE 3

2004 • 9 citations

CoMFA and CoMSIA Studies of nAChRs Ligands: Epibatidine Analogues

2004 • 6 citations

ChemInform Abstract: Synthesis of Analogues of (‐)‐Cytisine for in vivo Studies of Nicotinic Receptors Using Positron Emission Tomography.

2000 • 5 citations

ChemInform Abstract: Recent Syntheses of Epibatidine

2002 • 2 citations