Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

1992 • 553 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

1997 • 440 citations

Alkaloids: Chemical and biological perspectives

1986 • 401 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Studies in Natural Product Chemistry

2023 • 281 citations

Thirty Years of Discovering Arthropod Alkaloids in Amphibian Skin

1998 • 255 citations

Batrachotoxin: Chemistry and Pharmacology

1971 • 221 citations

Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.

1995 • 194 citations

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

1994 • 178 citations

Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

1999 • 169 citations

(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.

1994 • 166 citations

Chemistry of 7-Azabicyclo[2.2.1]hepta-2,5-dienes, 7-Azabicyclo[2.2.1]hept-2-enes, and 7-Azabicyclo[2.2.1]heptanes

1996 • 161 citations

[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study.

1995 • 159 citations

Structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs

1969 • 157 citations

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In Vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand

1996 • 136 citations

Synthesis and Nicotinic Acetylcholine Receptor in Vivo Binding Properties of 2-Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: A New Positron Emission Tomography Ligand for Nicotinic Receptors

1999 • 126 citations

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1999 • 114 citations

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

1998 • 94 citations

Stereocontrolled total synthesis of (+)- and (-)-epibatidine

1993 • 92 citations

(S)‐3‐メチル‐5‐(1‐メチル‐2‐ピロリジニル)イソキサゾール(ART418) 認知促進および抗不安活性を持つ新しいコリン作動性リガンド II in vivoの性質

1994 • 92 citations

A new class of indolizidine alkaloids from the poison frog, Dendrobates tricolor. X-ray analysis of 8-hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo[4.3.0]nonane

1980 • 91 citations

[125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors.

1997 • 91 citations

Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

1998 • 62 citations

Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors

1997 • 60 citations

Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.

1998 • 58 citations

ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain

1998 • 46 citations

Epibatidine and pain

1998 • 42 citations

A New Subclass of Alkaloids from a Dendrobatid Poison Frog: A Structure for Deoxypumiliotoxin 251H

1995 • 33 citations

Pumiliotoxin alkaloids: relationship of cardiotonic activity to sodium channel activity and phosphatidylinositol turnover

1988 • 31 citations

Synthesis and in vivo studies of [C-11]N-methylepibatidine: comparison of the stereoisomers

1999 • 25 citations

Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel.

1992 • 24 citations

Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice

1996 • 24 citations

The Isolation and Structure of Pumiliotoxin 341A: A Novel Cyclic Ether from the Frog Epipedobates tricolor

1999 • 6 citations