Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (35)
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
2003 • 7,170 citations
Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
1991 • 552 citations
From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor
1998 • 544 citations
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.
1999 • 522 citations
Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.
1997 • 387 citations
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca 2+ -binding sites
2002 • 262 citations
Neuronal nicotinic receptors: Molecular organization and regulations
1995 • 254 citations
Four Pharmacologically Distinct Subtypes of α4β2 Nicotinic Acetylcholine Receptor Expressed inXenopus laevisOocytes
1998 • 207 citations
Epibatidine is a nicotinic analgesic
1993 • 168 citations
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.
1998 • 166 citations
Synthesis of Analogues of (−)-Cytisine for in Vivo Studies of Nicotinic Receptors Using Positron Emission Tomography
2000 • 110 citations
Some studies on cytisine and its methylated derivatives
1969 • 99 citations
Relations between structure and nicotine‐like activity: X‐ray crystal structure analysis of (−)−cytisine and (−)−lobeline hydrochloride and a comparison with (−)−nicotine and other nicotine‐like compounds
1989 • 95 citations
(S)-(−)-5-Ethynyl-3-(1-methyl-2-pyrroli- dinyl)pyridine Maleate (SIB-1508Y): A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors
1996 • 91 citations
Central nicotinic receptor ligands and pharmacophores
2000 • 90 citations
Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands
2001 • 87 citations
Synthesis and preliminary pharmacological evaluation of some cytisine derivatives
1999 • 76 citations
Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘-Substituted 5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine Analogues
2001 • 74 citations
Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors
2001 • 63 citations
Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice
1998 • 53 citations
Multiple components in the agonist concentration–response relationships of neuronal nicotinic acetylcholine receptors
2000 • 47 citations
The unusual nature of epibatidine responses at the α4β2 nicotinic acetylcholine receptor
2000 • 47 citations
The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
1998 • 47 citations
An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors labelled by.
2001 • 43 citations
Chemical modification of epibatidine causes a switch from agonist to antagonist and modifies its selectivity for neuronal nicotinic acetylcholine receptors
2000 • 39 citations
Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands
1999 • 33 citations
Cloning and transient expression of genes encoding the human α4 and β2 neuronal nicotinic acetylcholine receptor (nAChR) subunits
1995 • 33 citations
Aromatic and benzylic hydroxyl substitution of imidazolines and phenethylamines: differences in activity at alpha-1 and alpha-2 adrenergic receptors.
1983 • 31 citations
Effects of diltiazem on human nicotinic acetylcholine and GABAA receptors
2000 • 26 citations
Über Cytisin und Ulexin
1894 • 23 citations
Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells.
2001 • 22 citations
A new look at the neuronal nicotinic acetylcholine receptor pharmacophore
2000 • 22 citations
Photoaffinity Labeling ofTorpedoNicotinic Receptor with the Agonist [3H]DCTA: Identification of Amino Acid Residues Which Contribute to the Binding of the Ester Moiety of Acetylcholine
2000 • 21 citations
Functional diversity among 5-substituted nicotine analogs; in vitro and in vivo investigations
2002 • 18 citations
ChemInform Abstract: Synthesis of Analogues of (‐)‐Cytisine for in vivo Studies of Nicotinic Receptors Using Positron Emission Tomography.
2000 • 5 citations