Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

2002 • 4,016 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents

2001 • 677 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Rapamycin in transplantation: A review of the evidence

2001 • 437 citations

The Solution Structure of the FATC Domain of the Protein Kinase Target of Rapamycin Suggests a Role for Redox-dependent Structural and Cellular Stability

2005 • 126 citations

PI 3-kinase, mTOR, protein synthesis and cancer

2001 • 122 citations

[12] Bromobimane probes for thiols

1995 • 113 citations

Iodophenylarsine oxide and arsenical affinity chromatography: new probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway.

1992 • 97 citations

An Intracellular Calcium Signal Activates p70 but Not p90 Ribosomal S6 Kinase in Liver Epithelial Cells

1997 • 79 citations

[43] Purification of vicinal dithiol-containing proteins by arsenical-based affinity chromatography

1994 • 44 citations

The Serine Protease Inhibitors, Tosylphenylalanine Chloromethyl Ketone and Tosyllysine Chloromethyl Ketone, Potently Inhibit pp70 Activation

1996 • 36 citations

Uptake and binding of radiolabelled phenylarsine oxide in 3T3-L1 adipocytes

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2002 • 12 citations