Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

2002 • 1,147 citations

The AMP-activated protein kinase cascade – a unifying system for energy control

2003 • 1,115 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

Molecular basis of the VHL hereditary cancer syndrome

2002 • 826 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

S6K1^−/−/S6K2^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 • 726 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 • 652 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Mutations in the tuberous sclerosis complex geneTSC2are a cause of sporadic pulmonary lymphangioleiomyomatosis

2000 • 624 citations

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1998 • 566 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 • 542 citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

2003 • 521 citations

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis

2002 • 515 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 491 citations

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

2003 • 460 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 460 citations

REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

2002 • 456 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

2002 • 373 citations

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

2003 • 371 citations

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

2000 • 366 citations

Molecular genetic advances in tuberous sclerosis

2000 • 354 citations

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

2004 • 294 citations

Growth suppression by Lkb1 is mediated by a G ₁ cell cycle arrest

1999 • 289 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

2004 • 160 citations

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.

2003 • 153 citations

An activating mutation in the γ1 subunit of the AMP‐activated protein kinase

2001 • 113 citations

Lymphatics at the crossroads of angiogenesis and lymphangiogenesis

2004 • 109 citations

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

1998 • 102 citations

Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent

2004 • 99 citations

Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.

2003 • 74 citations

Loss of tuberin, the tuberous‐sclerosis‐complex‐2 gene product is associated with angiogenesis

2001 • 37 citations

REDD2 Gene Is Upregulated by Modified LDL or Hypoxia and Mediates Human Macrophage Cell Death

2004 • 21 citations