Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Proline-Dependent Structural and Biological Properties of Peptides and Proteins

1993 • 548 citations

GPCRDB: an information system for G protein-coupled receptors

1998 • 331 citations

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1998 • 309 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Gut Peptides: Biochemistry and Physiology

1995 • 223 citations

Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction

1999 • 154 citations

Investigation of Glucose-dependent Insulinotropic Polypeptide(1-42) and Glucagon-like Peptide-1-(7-36) Degradation by Dipeptidyl Peptidase IV Using Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry

1996 • 153 citations

Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.

1995 • 125 citations

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist

1989 • 120 citations

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide

1999 • 104 citations

Constitutive Activity of Glucagon Receptor Mutants

1998 • 71 citations

Glucagon·Glucagon-like Peptide I Receptor Chimeras Reveal Domains That Determine Specificity of Glucagon Binding

1995 • 69 citations

Glucagon Metabolism in Man. Studies on the Metabolic Clearance Rate and the Plasma Acute Disappearance Time of Glucagon in Normal and Diabetic Subjects

1976 • 68 citations

Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs

1982 • 60 citations

Identification of an essential serine residue in glucagon: implication for an active site triad.

1994 • 58 citations

GIP6–30amide contains the high affinity binding region of GIP and is a potent inhibitor of GIP1–42action in vitro

1997 • 57 citations

Dipeptidyl peptidase IV (CD26) in metabolism and immune response

1995 • 54 citations

The Gly40Ser Mutation in the Human Glucagon Receptor Gene Associated With NIDDM Results in a Receptor With Reduced Sensitivity to Glucagon

1996 • 42 citations

Glucagon: Structure-Function Relationships Investigated by Sequence Deletions

1981 • 39 citations

Glucagon Antagonists: Contribution to Binding and Activity of the Amino-terminal Sequence 1–5, Position 12, and the Putative α-Helical Segment 19–27

1989 • 39 citations

The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.

1996 • 37 citations

Miniglucagon (Glucagon 19–29), a Potent and Efficient Inhibitor of Secretagogue-induced Insulin Release through a Ca2+Pathway

1999 • 36 citations

Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon

1991 • 36 citations

Positively Charged Residues at Positions 12, 17, and 18 of Glucagon Ensure Maximum Biological Potency

1998 • 22 citations

Specific Localization of Membrane Dipeptidase and Dipeptidyl Peptidase IV in Secretion Granules of Two Different Pancreatic Islet Cells

1999 • 22 citations

Glucagon and Liver Glucose Output In Vivo

1983 • 16 citations

Receptor occupancy and adenylate cyclase activation in rat liver and heart membranes by 10 glucagon analogs modified in position 2, 3, 4, 25, 27 and/or 29

1988 • 16 citations

Pure Glucagon Antagonists: Biological Activities and cAMP Accumulation Using Phosphodiesterase Inhibitors

1997 • 11 citations

On the stability of immunoreactive glucagon in plasma samples

1981 • 8 citations

Expression and signal transduction of the glucagon receptor in βTC3 cells

1997 • 7 citations

Isolation of glucagon antagonists by random molecular mutagenesis and screening.

1993 • 6 citations

Stability of Endogenous Immunoreactive Glucagon (IRG) in Animal Blood

1983 • 4 citations

The Renal Handling of Glucagon

1983 • 4 citations

The Use of MALDI-TOF Mass Spectrometry In Quantification of the Stability of Prolyl Endopeptidase Inhibitors

1996 • 1 citations