IGF‐1 and bFGF reduce glutaric acid and 3‐hydroxyglutaric acid toxicity in striatal cultures

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

1994 • 374 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

1991 • 310 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for <scp>l</scp>‐GLUTAMIC AND <scp>l</scp>‐ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT¹

1973 • 261 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Growth Factors and Taurine Protect against Excitotoxicity by Stabilizing Calcium Homeostasis and Energy Metabolism

1999 • 232 citations

Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action

1999 • 215 citations

Glial Cell Line‐Derived Neurotrophic Factor Exerts Neurotrophic Effects on Dopaminergic Neurons In Vitro and Promotes Their Survival and Regrowth After Damage by 1‐Methyl‐4‐Phenylpyridinium

1996 • 181 citations

Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity

1992 • 148 citations

Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide

1998 • 118 citations

Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis.

1993 • 104 citations

Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons

1995 • 100 citations

Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1

2000 • 100 citations

GDNF reduces apoptosis in dopaminergic neurons in vitro

1995 • 99 citations

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca²⁺ Responses to AMPA and NMDA in Hippocampal Neurons

1995 • 96 citations

Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor‐β superfamily, on midbrain dopaminergic neurons

1995 • 92 citations

Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and β-Hydroxyglutarate: Explanation of the symptoms in glutaric aciduria?

1976 • 92 citations

Glutaric aciduria type I: Pathomechanisms of neurodegeneration

1999 • 91 citations

Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation

1999 • 85 citations

Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro

1995 • 79 citations

BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia.

1999 • 79 citations

3-Hydroxyglutaric and glutaric acids are neurotoxic through NMDA receptors in vitro.

1998 • 77 citations

Glutaric aciduria: Inherited deficiency of glutaryl-CoA dehydrogenase activity

1975 • 77 citations

Differential Trophic Effects of Basic Fibroblast Growth Factor, Insulin-like Growth Factor-1, and Neurotrophin-3 on Striatal Neurons in Culture

1996 • 71 citations

Characterization and mechanism of glutamate neurotoxicity in primary striatal cultures

1990 • 70 citations

Hypothesis: A Role for Quinolinic Acid in the Neuropathology of Glutaric Aciduria Type I

1987 • 69 citations

bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal carcinoma cells during neuronal differentiation

1999 • 59 citations

Both FGF1 and Bcl-x synthesis are necessary for the reduction of apoptosis in retinal pigmented epithelial cells by FGF2: role of the extracellular signal-regulated kinase 2

1999 • 59 citations

Nerve cell lesions caused by 3‐hydroxyglutaric acid: A possible mechanism for neurodegeneration in glutaric acidaemia I

1997 • 59 citations

Maturation-Dependent Neurotoxicity of 3-Hydroxyglutaric and Glutaric Acids In Vitro : A New Pathophysiologic Approach to Glutaryl-CoA Dehydrogenase Deficiency

2000 • 59 citations

Inhibition of synaptosomal [3H]glutamate uptake and [3H]glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro

2000 • 58 citations

Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor

1999 • 53 citations

Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid

1998 • 50 citations

Hypoglycemia alters striatal amino acid efflux in perinatal rats: An in vivo microdialysis study

1990 • 41 citations

Insulin protects brain tissue against focal ischemia in rats

1992 • 37 citations

Roles of p53, c-Myc, Bcl-2, Bax and caspases in serum deprivation-induced neuronal apoptosis

1999 • 37 citations

Insulin Affects Dopamine Overflow in the Nucleus Accumbens and the Striatum

1998 • 30 citations

Cerebral organic acid disorders induce neuronal damage via excitotoxic organic acids in vitro

2000 • 29 citations

Brain and Plasma Quinolinic Acid in Profound Insulin‐Induced Hypoglycemia

1990 • 25 citations

Changing responsiveness of developing midbrain dopaminergic neurons for extracellular growth factors

1998 • 25 citations

Insulin‐Induced Oxidative Neuronal Injury in Cortical Culture: Mediation by Induced N‐Methyl‐D‐aspartate Receptors

1999 • 23 citations

Changing responsiveness of developing midbrain dopaminergic neurons for extracellular growth factors

1998 • 22 citations

Striatal dopamine metabolism is differentially affected by insulin according to the genotype in Zucker rats: A microdialysis study

1992 • 12 citations

Glutaric acidemia (type I)

1996 • 9 citations

Extracellular levels of quinolinic acid are moderately increased in rat neostriatum following severe insulin‐induced hypoglycaemia

1990 • 7 citations

Further studies on the role of calcium in the regulation of glutamate decarboxylase activity in brain slices

1983 • 4 citations