Involvement of dopamine D2/D3 receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Apoptosis in the nervous system

2000 • 1,850 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

CREB: A Major Mediator of Neuronal Neurotrophin Responses

1997 • 936 citations

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study

2003 • 832 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Dopamine Transporter Brain Imaging to Assess the Effects of Pramipexole vs Levodopa on Parkinson Disease Progression

2002 • 686 citations

Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man

1996 • 488 citations

Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies

2001 • 482 citations

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

1992 • 465 citations

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes

2002 • 464 citations

Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

1994 • 374 citations

Limitations of current Parkinson's disease therapy

2003 • 309 citations

Mitochondrial and nonmitochondrial reduction of MTT: Interaction of MTT with TMRE, JC‐1, and NAO mitochondrial fluorescent probes

2002 • 309 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

Dopaminergic neurons in rat ventral midbrain express brain‐derived neurotrophic factor and neurotrophin‐3 mRNAs

1994 • 290 citations

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

1994 • 270 citations

Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists

2003 • 264 citations

Extracellular‐Regulated Kinases and Phosphatidylinositol 3‐Kinase Are Involved in Brain‐Derived Neurotrophic Factor‐Mediated Survival and neuritogenesis of the Neuroblastoma Cell Line SH‐SY5Y

1999 • 263 citations

Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons

1998 • 225 citations

Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist

1999 • 205 citations

Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos

1999 • 196 citations

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. III. Agonist and Antagonist Properties at Serotonin, 5-HT₁ and 5-HT₂, Receptor Subtypes

2002 • 190 citations

Pramipexole Reduces Reactive Oxygen Species Production In Vivo and In Vitro and Inhibits the Mitochondrial Permeability Transition Produced by the Parkinsonian Neurotoxin Methylpyridinium Ion

1998 • 188 citations

Protective Effects of the Antiparkinsonian Drugs Talipexole and Pramipexole against 1-Methyl-4-phenylpyridinium-Induced Apoptotic Death in Human Neuroblastoma SH-SY5Y Cells

1998 • 183 citations

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. II. Agonist and Antagonist Properties at Subtypes of Dopamine D₂-Like Receptor and α₁/α₂-Adrenoceptor

2002 • 175 citations

The rationale for the use of dopamine agonists in Parkinson's disease

1995 • 145 citations

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go

2001 • 131 citations

A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.

1998 • 129 citations

Characterization and time course of MPP+-induced apoptosis in human SH-SY5Y neuroblastoma cells

1999 • 123 citations

S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.

2000 • 120 citations

Dopamine agonist monotherapy in Parkinson's disease

2002 • 115 citations

Substrate-dependence of reduction of MTT: a tetrazolium dye differs in cultured astroglia and neurons

2002 • 111 citations

Human Dopamine D₃Receptors Mediate Mitogen-Activated Protein Kinase Activation Via a Phosphatidylinositol 3-Kinase and an Atypical Protein Kinase C-Dependent Mechanism

1999 • 109 citations

Neuroprotection in Parkinson's disease: Clinical trials

2003 • 104 citations

Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

2000 • 103 citations

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade

2002 • 95 citations

Neuroprotective effects of the novel D3/D2 receptor agonist and antiparkinson agent, S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a comparison to ropinirole

2003 • 91 citations

G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study.

1999 • 90 citations

Therapeutic Potential of Nerve Growth Factors in Parkinson??s Disease

1999 • 89 citations

Effects of GDNF on 6‐OHDA‐induced death in a dopaminergic cell line: Modulation by inhibitors of PI3 kinase and MEK

2003 • 88 citations

Purification and Characterization of Gβγ-responsive Phosphoinositide 3-Kinases from Pig Platelet Cytosol

1997 • 84 citations

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

2003 • 77 citations

Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D_2(long), D₃ and D_4.4 receptors expressed in Chinese hamster ovary cells

1999 • 76 citations

1-Methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms

1995 • 76 citations

Neuroprotective effects of D3 dopamine receptor agonists

2001 • 72 citations

S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2, 3b]pyridine) and raclopride.

1998 • 70 citations

Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?

2001 • 69 citations

Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures.

1999 • 65 citations

Alterations in Nigrostriatal Dopaminergic Function within BDNF Mutant Mice

1999 • 64 citations

Methylpyridinium (MPP+)- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells

2002 • 59 citations

Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells.

1998 • 59 citations

Selective Activation of Gα_oby D_2LDopamine Receptors in NS20Y Neuroblastoma Cells

1998 • 57 citations

Medial nigral dopamine neurons have rich neurotrophin support in humans

1998 • 57 citations

Pramipexole inhibits MPTP toxicity in mice by dopamine D3 receptor dependent and independent mechanisms

2003 • 55 citations

Inhibitory Effects of Talipexole and Pramipexole on MPTP-Induced Dopamine Reduction in the Striatum of C57BL/6N Mice.

1997 • 52 citations

Disrupted mitochondrial electron transport function increases expression of anti-apoptotic Bcl-2 and Bcl-XL proteins in SH-SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress

2000 • 52 citations

Rationale for the use of dopamine agonists as neuroprotective agents in Parkinson's disease

2003 • 52 citations

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole

2004 • 47 citations

Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex

2004 • 35 citations

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole

2004 • 27 citations

Dopamine D2 receptor-mediated G-protein activation in rat striatum: functional autoradiography and influence of unilateral 6-hydroxydopamine lesions of the substantia nigra

2001 • 26 citations

Chronic supranigral infusion of BDNF in normal and MPTP-treated common marmosets

1999 • 22 citations