Controlled contusion injury alters molecular systems associated with cognitive performance

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

CREB AND MEMORY

1998 • 1,421 citations

Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

1993 • 1,302 citations

A controlled cortical impact model of traumatic brain injury in the rat

1991 • 1,123 citations

Functional reorganization of the brain in recovery from striatocapsular infarction in man

1992 • 879 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Extensive Cortical Rewiring after Brain Injury

2005 • 682 citations

Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.

1995 • 612 citations

Synapsins as mediators of BDNF-enhanced neurotransmitter release

2000 • 562 citations

Cell Death Mechanisms Following Traumatic Brain Injury

2004 • 529 citations

BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory Synapses

2001 • 506 citations

Contrasting acute and slow-growing lesions: a new door to brain plasticity

2006 • 477 citations

Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function

2004 • 473 citations

Large-Scale Sprouting of Cortical Connections After Peripheral Injury in Adult Macaque Monkeys

1998 • 442 citations

Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites

2003 • 410 citations

Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N -methyl- <scp>d</scp> -aspartic acid receptor activity

1998 • 406 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

1996 • 390 citations

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

1992 • 386 citations

Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus

1993 • 359 citations

Evaluation of Memory Dysfunction Following Experimental Brain Injury Using the Morris Water Maze

1991 • 352 citations

Cognitive Deficits Following Traumatic Brain Injury Produced by Controlled Cortical Impact

1992 • 348 citations

Targeting the CREB pathway for memory enhancers

2003 • 346 citations

Neuropsychological Sequelae of Minor Head Injury

1983 • 315 citations

Spatial and Temporal Characteristics of Neurodegeneration after Controlled Cortical Impact in Mice: More than a Focal Brain Injury

2005 • 307 citations

Motor and cognitive function evaluation following experimental traumatic brain injury

2004 • 298 citations

One-Year Study of Spatial Memory Performance, Brain Morphology, and Cholinergic Markers After Moderate Controlled Cortical Impact in Rats

1999 • 297 citations

Positive and negative regulatory mechanisms that mediate long-term memory storage

1998 • 270 citations

The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models

2000 • 265 citations

t Brain-Derived Neurotrophic Factor Overexpression Induces Precocious Critical Period in Mouse Visual Cortex

1999 • 264 citations

Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome

2007 • 236 citations

Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?

1998 • 228 citations

Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation.

1988 • 214 citations

Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?

1998 • 205 citations

Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits

1996 • 204 citations

Delayed, selective neuronal death following experimental cortical impact injury in rats: possible role in memory deficits

1996 • 203 citations

Evolution of Post-Traumatic Neurodegeneration after Controlled Cortical Impact Traumatic Brain Injury in Mice and Rats as Assessed by the De Olmos Silver and Fluorojade Staining Methods

2008 • 188 citations

Unilateral Cortical Contusion Injury in the Rat: Vascular Disruption and Temporal Development of Cortical Necrosis

1993 • 179 citations

Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation.

1988 • 174 citations

The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise

2004 • 171 citations

Time Window for Voluntary Exercise–Induced Increases in Hippocampal Neuroplasticity Molecules after Traumatic Brain Injury Is Severity Dependent

2007 • 169 citations

Cognitive and psychosocial outcome following moderate or severe traumatic brain injury

1999 • 166 citations

The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills

2006 • 165 citations

Neuroimaging Findings in Mild Traumatic Brain Injury *

2001 • 159 citations

Brain‐Derived Neurotrophic Factor Increases the Stimulation‐Evoked Release of Glutamate and the Levels of Exocytosis‐Associated Proteins in Cultured Cortical Neurons from Embryonic Rats

1997 • 146 citations

Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury

2006 • 144 citations

Characterization of Axonal Injury Produced by Controlled Cortical Impact

1990 • 143 citations

Hippocampal head atrophy after traumatic brain injury

2005 • 140 citations

Neuronal Cell Loss in the CA3 Subfield of the Hippocampus Following Cortical Contusion Utilizing the Optical Disector Method for Cell Counting

1997 • 139 citations

Calpain Activation Contributes to Dendritic Remodeling after Brief Excitotoxic InjuryIn Vitro

1997 • 136 citations

Vulnerability of Central Neurons to Secondary Insults afterIn VitroMechanical Stretch

2004 • 131 citations

Neurobehavioral consequences of traumatic brain injury.

2006 • 130 citations

Down‐regulation of cAMP‐dependent protein kinase by over‐activated calpain in Alzheimer disease brain

2007 • 130 citations

Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain

2004 • 129 citations

BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses

2006 • 125 citations

Synergistic Effects of Brain-Derived Neurotrophic Factor and Chondroitinase ABC on Retinal Fiber Sprouting after Denervation of the Superior Colliculus in Adult Rats

2003 • 124 citations

Cognitive Impairment in Patients With Traumatic Brain Injury and Obstructive Sleep Apnea

2007 • 123 citations

A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

2000 • 122 citations

Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats

2008 • 116 citations

Lateral fluid percussion injury in the developing rat causes an acute, mild behavioral dysfunction in the absence of significant cell death

2006 • 113 citations

Dissociable Long-Term Cognitive Deficits after Frontal versus Sensorimotor Cortical Contusions

1998 • 112 citations

Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury

1995 • 105 citations

Effects of Enriched Environment and Fluid Percussion Injury on Dendritic Arborization within the Cerebral Cortex of the Developing Rat

2002 • 104 citations

Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

1996 • 103 citations

Differential Effects of BDNF, ADNF9, and TNFα on Levels of NMDA Receptor Subunits, Calcium Homeostasis, and Neuronal Vulnerability to Excitotoxicity

2000 • 96 citations

Inhibition of Neocortical Plasticity During Development by a Moderate Concussive Brain Injury

2000 • 95 citations

Outcome following moderate traumatic brain injury

2003 • 93 citations

Traumatic Brain Injury in the Developing Rat: Effects of Maturation on Morris Water Maze Acquisition

1998 • 90 citations

Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury

2002 • 89 citations

Suppression of Insult-Induced Neurogenesis in Adult Rat Brain by Brain-Derived Neurotrophic Factor

2002 • 87 citations

Effects of lesions of the associative parietal cortex on the acquisition and use of spatial memory in egocentric and allocentric navigation tasks in the rat.

1996 • 86 citations

Concepts of CNS Plasticity in the Context of Brain Damage and Repair

2003 • 85 citations

Injury Severity Differentially Affects Short- and Long-Term Neuroendocrine Outcomes of Traumatic Brain Injury

2008 • 85 citations

Alterations in BDNF and Synapsin I within the Occipital Cortex and Hippocampus after Mild Traumatic Brain Injury in the Developing Rat: Reflections of Injury-Induced Neuroplasticity

2002 • 84 citations

Gender and environmental effects on regional brain-derived neurotrophic factor expression after experimental traumatic brain injury

2005 • 84 citations

Effects of lesions of the associative parietal cortex on the acquisition and use of spatial memory in egocentric and allocentric navigation tasks in the rat.

1996 • 77 citations

Hippocampally dependent and independent chronic spatial navigational deficits following parasagittal fluid percussion brain injury in the rat

1997 • 77 citations

The role of injury severity in neurobehavioral outcome 3 months after traumatic brain injury.

2002 • 75 citations

Models of brain injury and alterations in synaptic plasticity

2001 • 73 citations

Cognitive functions in relation to MRI findings 30 years after traumatic brain injury

2004 • 71 citations

Activation of Calcium/Calmodulin-Dependent Protein Kinases after Traumatic Brain Injury

2006 • 70 citations

Participation of CaMKII in neuronal plasticity and memory formation.

2002 • 65 citations

Relationship between dendritic pruning and behavioral recovery following sensorimotor cortex lesions

1998 • 58 citations

Calpain proteolysis of αII-spectrin in the normal adult human brain

2001 • 54 citations

Reorganization of the Hand Somatosensory Cortex Following Perinatal Unilateral Brain Injury

2000 • 52 citations

Time-Dependent Changes in Rat Brain Cholinergic Receptor Expression after Experimental Brain Injury

2002 • 52 citations

Effects of Exercise Following Lateral Fluid Percussion Brain Injury in Rats

1998 • 51 citations

Phosphorylation of Calcium Calmodulin—Dependent Protein Kinase II following Lateral Fluid Percussion Brain Injury in Rats

2007 • 49 citations

Spatial learning with unilateral and bilateral hippocampal networks

2005 • 45 citations

Quantitative analysis of contralateral hemisphere hypertrophy and sensorimotor performance in adult rats following unilateral neonatal ischemic-hypoxic brain injury

1996 • 44 citations

Traumatic Brain Injury and Hemorrhagic Hypotension Suppress Neuroprotective Gene Expression in Injured Hippocampal Neurons

2005 • 37 citations

Baclofen is neuroprotective and prevents loss of calcium/calmodulin‐dependent protein kinase II immunoreactivity in the ischemic gerbil hippocampus

2002 • 36 citations

Remodeling of cytoskeletal architecture of nonneuronal cells induced by synapsin.

1994 • 33 citations

Alterations in cerebral cortex microvessels and the microcirculation in a rat model of traumatic brain injury: a correlative EM and laser Doppler flowmetry study

2007 • 31 citations

Lateralized effect of unilateral somatosensory cortex contusion on behavior and cortical reorganization

1995 • 29 citations

Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory

1999 • 22 citations

Transient cerebral ischemia decreases calcium/ calmodulin-dependent protein kinase II immunoreactivity, but not mRNA levels in the gerbil hippocampus

1995 • 14 citations

[Regulatory mechanisms in focal cerebral ischemia. New possibilities in neuroprotective therapy].

2002 • 12 citations