Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

1989 • 1,126 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

1992 • 680 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth

1997 • 578 citations

Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord

1998 • 578 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

1997 • 500 citations

The Pathobiology of Traumatically Induced Axonal Injury in Animals and Humans: A Review of Current Thoughts

1995 • 492 citations

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function

1999 • 480 citations

Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling

1996 • 472 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

Progressive Atrophy and Neuron Death for One Year Following Brain Trauma in the Rat

1997 • 431 citations

Immunocytochemical localization of TrkB in the central nervous system of the adult rat

1997 • 426 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study.

1996 • 400 citations

Inhibition of GABA_ASynaptic Responses by Brain-Derived Neurotrophic Factor (BDNF) in Rat Hippocampus

1997 • 387 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus

1993 • 359 citations

Evaluation of Memory Dysfunction Following Experimental Brain Injury Using the Morris Water Maze

1991 • 352 citations

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

1996 • 350 citations

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

1993 • 333 citations

BDNF Protein Measured by a Novel Enzyme Immunoassay in Normal Brain and after Seizure: Partial Disagreement with mRNA Levels

1995 • 328 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Intraventricular Brain-Derived Neurotrophic Factor Reduces Infarct Size after Focal Cerebral Ischemia in Rats

1997 • 326 citations

Characteristics of BDNF-induced weight loss

1995 • 313 citations

Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat

1996 • 289 citations

Brain‐derived Neurotrophic Factor is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects them Against Glutamate‐induced Neurotoxicity

1993 • 287 citations

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

1992 • 281 citations

Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF

1997 • 280 citations

Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo.

1992 • 280 citations

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease

1995 • 269 citations

The NeurotroDhins BDNF, NT-3 and NT-4/5 Promote Survival and Morphological and Biochemical Differentiation of Striatal NeuronsIn Vitro

1995 • 262 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia

1992 • 247 citations

Signal Transduction Mediated by the Truncated trkB Receptor Isoforms, trkB.T1 and trkB.T2

1997 • 224 citations

Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres

1989 • 216 citations

Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action

1999 • 215 citations

Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression

1994 • 213 citations

BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons

1995 • 204 citations

BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones

1993 • 197 citations

Brain-derived neurotrophic factor (bdnf) can prevent apoptosis of rat cerebellar granule neurons in culture

1995 • 184 citations

Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury

1997 • 182 citations

Differential distribution of exogenous BDNF, NGF, and NT‐3 in the brain corresponds to the relative abundance and distribution of high‐affinity and low‐affinity neurotrophin receptors

1995 • 170 citations

Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury

1997 • 147 citations

Endogenous BDNF Protein Is Increased in Adult Rat Hippocampus after a Kainic Acid Induced Excitotoxic Insult but Exogenous BDNF Is Not Neuroprotective

1998 • 144 citations

Selective cognitive impairment following traumatic brain injury in rats

1993 • 140 citations

Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat

1992 • 138 citations

Efficacy of Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 on Neurochemical and Behavioral Deficits Associated with Partial Nigrostriatal Dopamine Lesions

1994 • 138 citations

Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma

1997 • 137 citations

Nerve Growth Factor Attenuates Cholinergic Deficits Following Traumatic Brain Injury in Rats

1997 • 127 citations

Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat

1997 • 125 citations

Ligand-induced down-regulation of trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons

1997 • 123 citations

Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts

1993 • 121 citations

Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population

1997 • 117 citations

Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat

1995 • 116 citations

The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain

1994 • 115 citations

Workshop on Animal Models of Traumatic Brain Injury

1994 • 114 citations

Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors

1995 • 110 citations

Clinical Neuro-Protection Trials in Severe Traumatic Brain Injury: Lessons from Previous Studies

1997 • 108 citations

Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

1996 • 103 citations

Effects of BDNF Infusion on the Regulation of TrkB Protein and Message in Adult Rat Brain

1997 • 101 citations

Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain

1995 • 98 citations

Interleukin-1 Receptor Antagonist Attenuates Regional Neuronal Cell Death and Cognitive Dysfunction after Experimental Brain Injury

1999 • 95 citations

Brain-Derived Neurotrophic Factor and Collagen Tubulization Enhance Functional Recovery After Peripheral Nerve Transection and Repair

1996 • 91 citations

Nerve Growth Factor Administration Attenuates Cognitive but Not Neurobehavioral Motor Dysfunction or Hippocampal Cell Loss Following Fluid‐Percussion Brain Injury in Rats

1995 • 90 citations

Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor

1995 • 90 citations

BDNF Up‐Regulates TrkB Protein and Prevents the Death of CA1 Neurons Following Transient Forebrain Ischemia

1998 • 89 citations

Posttreatment with Intravenous Basic Fibroblast Growth Factor Reduces Histopathological Damage Following Fluid-Percussion Brain Injury in Rats

1996 • 87 citations

Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury

1992 • 81 citations

Kynurenate is neuroprotective following experimental brain injury in the rat

1994 • 79 citations

Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat

1998 • 78 citations

Local application of collagen containing brain-derived neurotrophic factor decreases the loss of function after spinal cord injury in the adult rat

1998 • 77 citations

Delayed Administration of Basic Fibroblast Growth Factor (bFGF) Attenuates Cognitive Dysfunction Following Parasagittal Fluid Percussion Brain Injury in the Rat

1997 • 73 citations

Loss of Developing Cholinergic Basal Forebrain Neurons Following Excitotoxic Lesions of the Hippocampus: Rescue by Neurotrophins

1994 • 72 citations

Neurotrophin‐3 and Brain‐Derived Neurotrophic Factor Activate Multiple Signal Transduction Events but Are Not Survival Factors for Hippocampal Pyramidal Neurons

1996 • 71 citations

Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo-and limbic cortex in rat: Relationship to BDNF mRNA expressing neurons

1996 • 70 citations

BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage

1994 • 57 citations

Transient Neuronal Depolarization Induces Tolerance to Subsequent Forebrain Ischemia in Rats

1997 • 57 citations

Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma

1998 • 42 citations

Intraparenchymal NGF Injections in Adult and Aged Rats Induce Long-Lasting Trk Tyrosine Phosphorylation

1996 • 36 citations

Activation of ras and protection from apoptotic cell death by BDNF in PC12 cells expressing trkB

1996 • 16 citations