Differential Targeting of Gßγ-Subunit Signaling with Small Molecules

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

A Fast Flexible Docking Method using an Incremental Construction Algorithm

1996 • 2,706 citations

Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

2004 • 1,614 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Insights into G Protein Structure, Function, and Regulation

2003 • 639 citations

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

1998 • 440 citations

Consensus scoring for ligand/protein interactions

2002 • 403 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

OPIOID RECEPTOR SIGNALLING MECHANISMS

1999 • 254 citations

Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase.

1997 • 149 citations

Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

1999 • 148 citations

Protein–protein interfaces: mimics and inhibitors

2001 • 134 citations

G Proteins in Cancer: The Prostate Cancer Paradigm

2004 • 117 citations

Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase

1998 • 113 citations

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors

2001 • 103 citations

Targeting G _βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis

1999 • 87 citations

Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein βγ Subunits

2005 • 79 citations

Determinants of Gi1α and βγ Binding

1998 • 70 citations

Transgenic Mice Targeting the Heart Unveil G Protein-Coupled Receptor Kinases as Therapeutic Targets

2003 • 23 citations