The biological role of nitric oxide in bacteria

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Biology of anaerobic microorganisms

1989 • 2,196 citations

Membrane protein structure prediction

1992 • 1,680 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

¹⁵ N Kinetic Analysis of N ₂ O Production by Nitrosomonas europaea : an Examination of Nitrifier Denitrification

1985 • 629 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

The N-End Rule in Bacteria

1991 • 536 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Relative Rates of Nitric Oxide and Nitrous Oxide Production by Nitrifiers, Denitrifiers, and Nitrate Respirers

1986 • 376 citations

Production of NO and N2O by soil nitrifying bacteria

1981 • 356 citations

The 2.3 Angstrom X-Ray Structure of Nitrite Reductase from Achromobacter cycloclastes

1991 • 352 citations

Why nitric oxide?

1992 • 350 citations

Denitrification by fungi

1992 • 335 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Denitrification by fungi

1992 • 330 citations

Investigations on the denitrifying process in soil

1954 • 300 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates

1991 • 281 citations

Pseudomonas: molecular biology and biotechnology.

1992 • 259 citations

Cytochrome P-450 55A1 (P-450dNIR) acts as nitric oxide reductase employing NADH as the direct electron donor.

1993 • 250 citations

Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction

1991 • 250 citations

Studies on thiobacillus denitrificans

1954 • 212 citations

Nitric oxide, a biological effector

1991 • 203 citations

Immunological identification and distribution of dissimilatory heme cd1 and nonheme copper nitrite reductases in denitrifying bacteria

1989 • 202 citations

Transfer of Thiosphaera pantotropha to Paracoccus denitrificans

1993 • 191 citations

Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri

1989 • 184 citations

Effects of nitric oxide and nitrogen dioxide on bacterial growth

1983 • 182 citations

Trapping of nitric oxide produced during denitrification by extracellular hemoglobin.

1988 • 176 citations

Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on anr, a regulatory gene homologous with fnr of Escherichia coli

1991 • 175 citations

Production of nitric oxide in Nitrosomonas europaea by reduction of nitrite

1990 • 162 citations

Steady-state nitric oxide concentrations during denitrification.

1990 • 157 citations

Nitric oxide: linking space and time in the brain.

1992 • 149 citations

Energy Yield of Denitrification: An Estimate from Growth Yield in Continuous Cultures of Pseudomonas denitrificans under Nitrate-, Nitrite- and Nitrous Oxide-limited Conditions

1975 • 143 citations

The nirSTBM region coding for cytochrome cd₁‐dependent nitrite respiration of Pseudomonas stutzeri consists of a cluster of mono‐, di‐, and tetraheme proteins

1991 • 142 citations

The location of dissimilatory nitrite reductase and the control of dissimilatory nitrate reductase by oxygen in Paracoccus denitrificans

1980 • 139 citations

The impact of organic matter on nitric oxide formation by Nitrosomonas europaea

1992 • 133 citations

Reactive nitrogen intermediates suppress the primary immunologic response to Listeria.

1993 • 130 citations

Purification and Properties of a Copper-Containing Nitrite Reductase from a Denitrifying Bacterium, Alcaligenes faecalis Strain S-6

1981 • 125 citations

Copper-containing nitrite reductase from Pseudomonas aureofaciens is functional in a mutationally cytochrome cd 1-free background (NirS−) of Pseudomonas stutzeri

1993 • 122 citations

The nitric oxide reductase of Paracoccus denitrificans

1990 • 120 citations

Cytochrome P450 catalyzes the oxidation of Nω-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline

1992 • 117 citations

Isolation and characterization of a nitrite reductase gene and its use as a probe for denitrifying bacteria

1992 • 116 citations

Nitrosamine Formation by Denitrifying and Non-denitrifying Bacteria: Implication of Nitrite Reductase and Nitrate Reductase in Nitrosation Catalysis

1988 • 113 citations

Nitrogen 15 tracer studies on the pathway of denitrification in Pseudomonas aeruginosa.

1977 • 102 citations

The effect of oxygen on denitrification during steady-state growth of Paracoccus halodenitrificans

1984 • 100 citations

Unraveling the biological significance of nitric oxide.

1990 • 100 citations

Evidence that the Type 2 copper centers are the site of nitrite reduction by Achromobacter cycloclastes nitrite reductase

1992 • 99 citations

Oxygen-regulated gene expression in Escherichia coli: (Delivered at the 122nd Ordinary Meeting of the Society for General Microbiology, 25 March 1992)

1992 • 99 citations

Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions

1990 • 99 citations

Growth inhibition of Francisella tularensis live vaccine strain by IFN-gamma-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism.

1992 • 98 citations

The reaction of Pseudomonas nitrite reductase and nitrite. A stopped-flow and EPR study.

1990 • 97 citations

Nitrite reductase from Pseudomonas aeruginosa: Sequence of the gene and the protein

1989 • 96 citations

Separate Nitrite, Nitric Oxide, and Nitrous Oxide Reducing Fractions from Pseudomonas perfectomarinus

1971 • 91 citations

H218O isotope exchange studies on the mechanism of reduction of nitric oxide and nitrite to nitrous oxide by denitrifying bacteria. Evidence for an electrophilic nitrosyl during reduction of nitric oxide

1991 • 91 citations

Nitric and nitrous oxide reductases are active under aerobic conditions in cells of Thiosphaera pantotropha

1991 • 91 citations

The Effect of Nitric Oxide on Bacteria

1962 • 90 citations

Evidence for an NO‐rebound, mechanism for production of N₂O from nitrite by the copper‐containing nitrite reductase from Achromobacter cycloclastes

1991 • 89 citations

Nitric oxide-dependent proton translocation in various denitrifiers

1985 • 88 citations

Marker exchange of the structural genes for nitric oxide reductase blocks the denitrification pathway of Pseudomonas stutzeri at nitric oxide.

1991 • 87 citations

Periplasmic location of the terminal reductase in nitrite respiration

1978 • 87 citations

Nitric oxide reductase. Purification from Paracoccus denitrificans with use of a single column and some characteristics

1991 • 87 citations

The energy‐conserving nitric‐oxide‐reductase system in Paracoccus denitrificans

1989 • 85 citations

Nitric Oxide and Nitrous Oxide Production and Cycling During Dissimilatory Nitrite Reduction by Pseudomonas Perfectomarina

1989 • 84 citations

Defects in cytochrome cd 1-dependent nitrite respiration of transposon Tn5-induced mutants from Pseudomonas stutzeri

1988 • 83 citations

NO, thiols and disulfides

1993 • 83 citations

Characterization of Nitrite Reductase from a Denitrifier, Alcaligenes Sp. NCIB 11015. A Novel Copper Protein1

1984 • 82 citations

Metabolism of nitric oxide in soil and denitrifying bacteria

1991 • 81 citations

Killing of Legionella pneumophila by nitric oxide in γ-interferon-activated macrophages

1992 • 81 citations

Regulation of the hexaheme nitrite/nitric oxide reductase of Desulfovibrio desulfuricans, Wolinella succinogenes and Escherichia coli

1990 • 78 citations

Identification of nitric oxide reductase activity in Rhodobacter capsulatus: the electron transport pathway can either use or bypass both cytochrome c2 and the cytochrome bc1 complex

1992 • 76 citations

NO accounts completely for the oxygenated nitrogen species generated by enzymic <scp>l</scp>-arginine oxygenation

1992 • 76 citations

Purification and Some Characteristics of a Cytochrome c-containing Nitrous Oxide Reductase from Wolinella succinogenes

1989 • 76 citations

Studies on Denitrification

1968 • 74 citations

Type 1, blue copper proteins constitute a respiratory nitrite‐reducing system in Pseudomonas aureofaciens

1987 • 74 citations

A ‘blue’ copper oxidase from Nitrosomonas europaea

1985 • 73 citations

Characterization of the structural gene encoding a copper-containing nitrite reductase and homology of this gene to DNA of other denitrifiers

1993 • 72 citations

Interdependence of respiratory NO reduction and nitrite reduction revealed by mutagenesis of nirQ, a novel gene in the denitrification gene cluster of Pseudomonas stutzeri

1992 • 72 citations

L-arginine-dependent killing of intracellular Ehrlichia risticii by macrophages treated with gamma interferon

1992 • 71 citations

Comparison of carbon monoxide, nitric oxide, and nitrite as inhibitors of the nitrogenase from Clostridium pasteurianum

1981 • 70 citations

Amino acid sequence of nitrite reductase: a copper protein from Achromobacter cycloclastes

1991 • 69 citations

Mechanism for nitrosation of 2,3-diaminonaphthalene by Escherichia coli: enzymatic production of NO followed by O2-dependent chemical nitrosation

1988 • 69 citations

The kinetic and isotopic competence of nitric oxide as an intermediate in denitrification.

1990 • 66 citations

Evidence from isotope labeling studies for a sequential mechanism for dissimilatory nitrite reduction

1988 • 62 citations

A bacterial c‐type cytochrome can be translocated to the periplasm as an apo form; the biosynthesis of cytochrome cd₁ (nitrite reductase) from Paracoccus denitrificans

1989 • 62 citations

Ferrous iron dependent nitric oxide production in nitrate reducing cultures of Escherichia coli

1991 • 61 citations

An introduction to the global nitrogen cycle

1990 • 60 citations

Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli

1988 • 60 citations

Mutants of Pseudomonas fluorescens deficient in dissimilatory nitrite reduction are also altered in nitric oxide reduction

1992 • 60 citations

Inhibition of nitrous-oxide respiration by nitric oxide in the denitrifying bacterium Pseudomonas perfectomarina

1986 • 54 citations

Nitrogen isotopic fractionation and 18O exchange in relation to the mechanism of denitrification of nitrite by Pseudomonas stutzeri.

1988 • 54 citations

Periplasmic location of dissimilatory nitrate and nitrite reductases in a denitrifying phototrophic bacterium, &lt;italic&gt;Rhodopseudomonas sphaeroides&lt;/italic&gt; forma sp. &lt;italic&gt;denitrificans&lt;/italic&gt;

1980 • 53 citations

The Soluble Cytochrome Oxidase of Nitrosomonas europaea

1983 • 52 citations

Enzymatic Steps of Dissimilatory Nitrite Reduction in Alcaligenes faecalis

1971 • 52 citations

Structure of dioneheme. Total synthesis of the green heme prosthetic group in cytochrome cd1 dissimilatory nitrite reductase

1987 • 52 citations

The denitrifying nitrite reductase of Bacillus halodenitrificans

1991 • 52 citations

Metabolism of nitric oxide in denitrifyingPseudomonas aeruginosaand nitrate-respiringBacillus cereus

1991 • 50 citations

The structural genes of the nitric oxide reductase complex from Pseudomonas stutzeri are part of a 30-kilobase gene cluster for denitrification

1992 • 50 citations

Detergent inhibition of nitric-oxide reductase activity

1987 • 50 citations

Reduction of nitrite to nitrous oxide by a cytoplasmic membrane fraction from the marine denitrifier Pseudomonas perfectomarinus

1979 • 49 citations

The bacteriocidal effects of transition metal complexes containing the NO⁺group on the food-spoilage bacteriumClostridium sporogenes

1992 • 49 citations

Nitric Oxide Complex of Cytochrome c' in Cells of Denitrifying Bacteria

1988 • 47 citations

Discrimination of ascorbate-dependent nonenzymatic and enzymatic, membrane-bound reduction of nitric oxide in denitrifying Pseudomonas perfectomarinus

1982 • 47 citations

Characterization of crystals of a cytochrome oxidase (nitrite reductase) from Pseudomonas aeruginosa by X-ray diffraction and electron microscopy

1980 • 44 citations

Nitrite reductase activity of Pseudomonas cytochrome oxidase

1960 • 43 citations

Anaerobic expression of nitric oxide reductase from denitrifying Pseudomonas stutzeri

1993 • 42 citations

Studies on Denitrification&lt;subtitle&gt;VII. Further Purification and Properties of Denitrifying Enzyme&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;*&lt;/sup&gt;&lt;/xref&gt;&lt;/subtitle&gt;

1963 • 41 citations

The Effect of Nitric Oxide on Bacteria

1962 • 41 citations

The inorganic biochemistry of nitrogen bioenergetic processes

1979 • 40 citations

Close linkage in Pseudomonas stutzeri of the structural genes for respiratory nitrite reductase and nitrous oxide reductase, and other essential genes for denitrification

1991 • 39 citations

Nitric oxide can modify amino acid residues in proteins

1992 • 38 citations

Positional isotopic equivalence of nitrogen in N2O produced by the denitrifying bacterium Pseudomonas stutzeri. Indirect evidence for a nitroxyl pathway.

1982 • 37 citations

The production and utilization of nitric oxide by a new, denitrifying strain of Pseudomonas aeruginosa

1991 • 37 citations

Localization of the cytochrome cd1 and copper nitrite reductases in denitrifying bacteria

1990 • 33 citations

Metabolism of nitric oxide byPseudomonas stutzeriin culture and in soil

1993 • 32 citations

Proton translocation and proline uptake associated with reduction of nitric oxide by denitrifying Paracoccus denitrificans

1982 • 32 citations

Nitrite, a new substrate for nitrogenase

1989 • 31 citations

Studies on Denitrification

1969 • 31 citations

The purification and properties of a cd-cytochrome nitrite reductase from Paracoccus halodenitrificans

1986 • 30 citations

Purification and some characteristics of nitric oxide reductase-containing vesicles from Paracoccus denitrificans

1989 • 30 citations

Solubilization and resolution of the membrane-bound nitrite reductase from Paracoccus halodenitrificans into nitrite and nitric oxide reductases

1984 • 28 citations

Characterization of Tn5 mutants deficient in dissimilatory nitrite reduction in Pseudomonas sp. strain G-179, which contains a copper nitrite reductase

1992 • 27 citations

Oscillations of nitric oxide concentration in the perturbed denitrification pathway of Paracoccus denitrificans

1992 • 25 citations

Anaerobically induced expression of the nitrite reductase cytochrome c‐551 operon from Pseudomonas aeruginosa

1991 • 25 citations

The Properties of Novel Mesophilic Denitrifying Bacillus Cultures Found in Tropical Soils

1979 • 25 citations

Nitric oxide‐releasing compounds inhibit Dictyostelium discoideum aggregation without altering cGMP production

1992 • 24 citations

Cadmium-copper antagonism in the activation of periplasmic nitrous oxide reductase of copper-deficient cells fromPseudomonas stutzeri

1988 • 23 citations

Periplasmic location of nitrous oxide reductase and its apoform in denitrifying Pseudomonas stutzeri

1992 • 23 citations

Inhibition of nitrogenase by nitrite and nitric oxide in Rhodopseudomonas sphaeroides f. sp. denitrificans

1987 • 22 citations

Isolation of an enzyme catalysing nitrosamine formation in Pseudomonas aeruginosa and Neisseria mucosae

1990 • 21 citations

STUDIES ON DENITRIFICATION

1956 • 20 citations

Involvement of cytochrome bc₁ complex and cytochrome c₂ in the electron‐transfer pathway for NO reduction in a photodenitrifier, Rhodobacter sphaeroides f.s. denitrificans

1989 • 20 citations

Patterns of product inhibition for bacterial nitrite reductase

1984 • 17 citations

Inhibition of electron transfer through the cytochrome b-c 1 complex by nitric oxide in a photodenitrifier, Rhodopseudomonas sphaeroides forma sp. denitrificans

1984 • 16 citations

Evidence for cytochrome bc₁ complex involvement in nitrite reduction in a photodenitrifier, Rhodopseudomonas sphaeroides forma sp. denitrificans

1984 • 16 citations

Biosynthetic Origins of the Carbon Skeleton of Heme d1

1993 • 15 citations

The bacteriocidal effects of transition metal complexes containing the NO+ group on the food-spoilage bacterium Clostridium sporogenes

1992 • 15 citations

Production of nitric oxide by ammonium-oxidizing bacteria colonizing building stones

1991 • 14 citations

Enzyme localization and orientation of the active site of dissimilatory nitrite reductase from Bacillus firmus

1991 • 12 citations

Novel Terminal Oxidoreductases of Anaerobic Respiration (Denitrification) from Pseudomonas

1987 • 10 citations

Nitrate reduction and N-nitrosation by Obesumbacterium proteus

1992 • 6 citations

In vivo inhibition of nitrogenase by hydroxylamine in Rhodospirillaceae Role of nitric oxide

1992 • 6 citations

The rapid nitrosation of 2,3-diaminonaphthalene by gastric isolates of Neisseria subflava

1990 • 5 citations

No Lack of NO Activity

1993 • 2 citations